Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Ilana Nathan"'
Publikováno v:
Journal of Medicinal Chemistry. 64:1510-1523
Necrosis is the main mode of cell death, which leads to multiple clinical conditions affecting hundreds of millions of people worldwide. Its molecular mechanisms are poorly understood, hampering therapeutics development. Here, we identify key proteol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23c4dba5d0a034e8b43ed19b9aaeead5
https://doi.org/10.1021/acs.jmedchem.0c01683
https://doi.org/10.1021/acs.jmedchem.0c01683
Autor:
Maher Hallak, Michael Danilenko, Thida Win, Shmuel Bittner, Yosef Granot, Ofer Shpilberg, Itai Levi, Ilana Nathan
Publikováno v:
Molecular and cellular biochemistry.
Novel derivatives of aminophenyl-1,4-naphthoquinones, in which a pyrrolidine group was added to the naphthoquinone ring, were synthesized and investigated for the mechanisms of leukemic cell killing. The novel compounds, TW-85 and TW-96, differ in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada4ec6a85c6c5579f9ee91dc01c17b9
https://pubmed.ncbi.nlm.nih.gov/35836027
https://pubmed.ncbi.nlm.nih.gov/35836027
Publikováno v:
Journal of medicinal chemistry. 64(3)
Necrosis is the main mode of cell death, which leads to multiple clinical conditions affecting hundreds of millions of people worldwide. Its molecular mechanisms are poorly understood, hampering therapeutics development. Here, we identify key proteol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01f2d44f71a354b03828406258d35b62
https://pubmed.ncbi.nlm.nih.gov/33522230
https://pubmed.ncbi.nlm.nih.gov/33522230
Publikováno v:
Biophysical Journal. 121:271a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17483bfa3d5b715b684bfb539c38a815
https://doi.org/10.1016/j.bpj.2021.11.1390
https://doi.org/10.1016/j.bpj.2021.11.1390
Autor:
Aviv Cohen, Roni Kasher, Ilana Nathan, Abraham H. Parola, Lakshminarasaiah Uppalapati, Boris Khalfin, David Meridor
Publikováno v:
International Journal of Peptide Research and Therapeutics. 25:565-571
Until recently, necrotic cells death was considered an uncontrolled process. However, evidence was recently presented that necrosis is a regulated process associated with many clinical conditions. Humanin and its derivatives are peptides known for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::055e2c1d367c39fcc6ecb60183a05180
https://doi.org/10.1007/s10989-018-9700-2
https://doi.org/10.1007/s10989-018-9700-2
Autor:
Ilana Nathan, Abraham H. Parola, Jenny Lerner-Yardeni, Aviv Cohen, David Meridor, Roni Kasher
Publikováno v:
Biochemistry & Molecular Biology Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76bec23cca3647000f6c1f4c045a9260
https://doi.org/10.21767/2471-8084.100057
https://doi.org/10.21767/2471-8084.100057
Autor:
Felix Flomen, Nir Wasserberg, Shaul Mordechai, Joseph Kapelushnik, Cheli Segev, Ilana Nathan, Udi Zelig, Omri Bar, Ram Dickman, Eyal Barlev, Hanoch Kashtan, Osnat Madhala-Givon
Publikováno v:
Journal of Gastroenterology. 51:214-221
Early detection of colorectal cancer (CRC) can reduce mortality and morbidity. Current screening methods include colonoscopy and stool tests, but a simple low-cost blood test would increase compliance. This preliminary study assessed the utility of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3af1e0cf0bf9c1be97251ae20caba9
https://doi.org/10.1007/s00535-015-1095-7
https://doi.org/10.1007/s00535-015-1095-7
Publikováno v:
Chemistry and Physics of Lipids. 183:159-168
Cardiolipin (CL) is a unique anionic, dimeric phospholipid found almost exclusively in the inner mitochondrial membrane and is essential for the function of numerous enzymes that are involved in mitochondrial energy metabolism. While the role of card
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a461fa3d34927729849d2fc2ef0296a
https://doi.org/10.1016/j.chemphyslip.2014.06.007
https://doi.org/10.1016/j.chemphyslip.2014.06.007
Autor:
Thida Win, Ilana Nathan, Itai Levy, Ofer Shpilberg, Yosef Granot, Shmuel Bittner, Maher Hallak
Publikováno v:
British Journal of Haematology. 147:459-470
Summary Naphthoquinones, such as menadione, display lower toxicity than anthracyclins used in cancer chemotherapy. Novel anti-leukaemic compounds comprised of chloro-amino-phenyl naphthoquinones with substitutions on the benzoic ring were developed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57399d3a6f19dd9aea646d341efc0db9
https://doi.org/10.1111/j.1365-2141.2009.07867.x
https://doi.org/10.1111/j.1365-2141.2009.07867.x
Publikováno v:
Apoptosis. 13:147-155
Mimosine, a non-protein amino acid, is mainly known for its action as a reversible inhibitor of DNA replication and, therefore, has been widely used as a cell cycle synchronizing agent. Recently, it has been shown that mimosine also induces apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d21a0efe150bfb7684e1ffafddcaf3
https://doi.org/10.1007/s10495-007-0156-7
https://doi.org/10.1007/s10495-007-0156-7