Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ilana Moscatelli"'
Autor:
Ilana Moscatelli, Elena Almarza, Axel Schambach, David Ricks, Ansgar Schulz, Christopher D. Herzog, Kim Henriksen, Maria Askmyr, Jonathan D. Schwartz, Johan Richter
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 389-397 (2021)
Infantile malignant osteopetrosis is a devastating disorder of early childhood that is frequently fatal and for which there are only limited therapeutic options. Gene therapy utilizing autologous hematopoietic stem and progenitor cells represents a p
Externí odkaz:
https://doaj.org/article/c0603ecb4f8d4f5388fd9fa854ead6c3
Autor:
Xiaojie Xian, Roksana Moraghebi, Henrik Löfvall, Anders Fasth, Kim Henriksen, Johan Richter, Niels-Bjarne Woods, Ilana Moscatelli
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-9 (2020)
Abstract Background Infantile malignant osteopetrosis (IMO) is an autosomal recessive disorder characterized by non-functional osteoclasts and a fatal outcome early in childhood. About 50% of patients have mutations in the TCIRG1 gene. Methods IMO iP
Externí odkaz:
https://doaj.org/article/cc0206baf35e46ab9cc9094f329d2a6c
Autor:
Odelia Chorin, Naomi Yachelevich, Khaled Mohamed, Ilana Moscatelli, John Pappas, Kim Henriksen, Gilad D. Evrony
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 10, Pp n/a-n/a (2020)
Abstract Background Over half of children with rare genetic diseases remain undiagnosed despite maximal clinical evaluation and DNA‐based genetic testing. As part of an Undiagnosed Diseases Program applying transcriptome (RNA) sequencing to identif
Externí odkaz:
https://doaj.org/article/2f07666bfc464a67a7bb41e95b59e11f
Autor:
Luisa Campagnolo, Gaetana Costanza, Arianna Francesconi, Gaetano Arcuri, Ilana Moscatelli, Augusto Orlandi
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84969 (2014)
BackgroundSortilin, a member of the Vps10p-domain receptor family, has been demonstrated a key regulator in mediating cellular response to pro-neurotrophins. In the present study, we investigated the role of sortilin in the apoptotic pathway of vascu
Externí odkaz:
https://doaj.org/article/dd3703b608574afd9b290ba3780569c2
Autor:
Carmen Flores, Ilana Moscatelli, Christian S. Thudium, Natasja Stæhr Gudmann, Jesper S. Thomsen, Annemarie Brüel, Morten A. Karsdal, Kim Henriksen, Johan Richter
Publikováno v:
Haematologica, Vol 98, Iss 12 (2013)
The osteoclast is vital for establishment of normal hematopoiesis in the developing animal. However, its role for maintenance of hematopoiesis in adulthood is more controversial. To shed more light on this process, we transplanted hematopoietic stem
Externí odkaz:
https://doaj.org/article/3da24475bb8a439ca2340ff667e2d5c2
Autor:
Jonathan D. Schwartz, Elena Almarza, Axel Schambach, Kim Henriksen, David Ricks, Maria Askmyr, Christopher D. Herzog, Johan Richter, Ansgar Schulz, Ilana Moscatelli
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 389-397 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Infantile malignant osteopetrosis is a devastating disorder of early childhood that is frequently fatal and for which there are only limited therapeutic options. Gene therapy utilizing autologous hematopoietic stem and progenitor cells represents a p
Autor:
Ilana Moscatelli, Kim Henriksen, Odelia Chorin, Naomi Yachelevich, Gilad D. Evrony, John Pappas, Khaled Mohamed
Publikováno v:
Molecular Genetics & Genomic Medicine
Molecular Genetics & Genomic Medicine, Vol 8, Iss 10, Pp n/a-n/a (2020)
Molecular Genetics & Genomic Medicine, Vol 8, Iss 10, Pp n/a-n/a (2020)
Background Over half of children with rare genetic diseases remain undiagnosed despite maximal clinical evaluation and DNA‐based genetic testing. As part of an Undiagnosed Diseases Program applying transcriptome (RNA) sequencing to identify the cau
Autor:
Ilana Moscatelli, Kim Henriksen, Niels-Bjarne Woods, Anders Fasth, Henrik Löfvall, Johan Richter, Xiaojie Xian, Roksana Moraghebi
Publikováno v:
Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-9 (2020)
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-9 (2020)
Background Infantile malignant osteopetrosis (IMO) is an autosomal recessive disorder characterized by non-functional osteoclasts and a fatal outcome early in childhood. About 50% of patients have mutations in the TCIRG1 gene. Methods IMO iPSCs were
Autor:
Axel Schambach, Ilana Moscatelli, Kim Henriksen, Johan Richter, Carmen P. Montano Almendras, Christian S. Thudium, Henrik Löfvall
Publikováno v:
European Journal of Haematology. 98:517-526
Objectives Here we tested the hypothesis that human M-CSF (hM-CSF) overexpressed in CB CD34+ cells would induce differentiation and survival of monocytes and osteoclasts in vitro and in vivo. Methods Human M-CSF was overexpressed in cord blood CD34+
Autor:
Michael Rothe, Kim Henriksen, Henrik Löfvall, Johan Richter, Ilana Moscatelli, Axel Schambach
Publikováno v:
Human gene therapy. 30(11)
Infantile malignant osteopetrosis (IMO) is an autosomal recessive disorder characterized by nonfunctional osteoclasts. Approximately 50% of the patients have mutations in the TCIRG1 gene, encoding ...