Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ilana M. Roberts"'
Autor:
Paul Nghiem, Cassian Yee, David M. Koelle, Cindy Desmarais, Ted Gooley, Kendall C. Shibuya, Shailender Bhatia, Heather L. Sloan, Ilana M. Roberts, Ivy Lai, Joo Ha Hwang, Upendra Parvathaneni, Kelly G. Paulson, Jayasri G. Iyer, Olga K. Afanasiev, Aude G. Chapuis
PDF file - 738K, Supplementary Fig. S1: Detection of MCPyV-specific CD8 T cells among tumor infiltrating lymphocytes (TIL) from the primary MCC tumor (left) and PBMC (right). Cells were stained with A24/MCPyV.LT.92-101 tetramer and CD8. Supplementary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db7e984993205f4f853e71a39c28e16
https://doi.org/10.1158/2326-6066.22535900.v1
https://doi.org/10.1158/2326-6066.22535900.v1
Autor:
Paul Nghiem, Cassian Yee, David M. Koelle, Cindy Desmarais, Ted Gooley, Kendall C. Shibuya, Shailender Bhatia, Heather L. Sloan, Ilana M. Roberts, Ivy Lai, Joo Ha Hwang, Upendra Parvathaneni, Kelly G. Paulson, Jayasri G. Iyer, Olga K. Afanasiev, Aude G. Chapuis
Merkel cell carcinoma (MCC) is an aggressive skin cancer that typically requires the persistent expression of Merkel cell polyomavirus (MCPyV) oncoproteins that can serve as ideal immunotherapeutic targets. Several immune evasion mechanisms are activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f31668861506a1e7777cf2fede8524bc
https://doi.org/10.1158/2326-6066.c.6547979.v1
https://doi.org/10.1158/2326-6066.c.6547979.v1
Autor:
Aude G. Chapuis, Felecia Wagener, Ilana M. Roberts, Ivy Lai, Philip D. Greenberg, Kendall C. Shibuya, Heather L. Sloan, Jedd D. Wolchok, Shailender Bhatia, Kim Margolin, Cassian Yee, Jianhong Cao, John A. Thompson, Sylvia Lee
Publikováno v:
The Journal of Experimental Medicine
Chapuis et al. demonstrate that the combination of adoptive cellular therapy with CTLA4 blockade induces long-term remission in a melanoma patient resistant to both modalities administered serially and individually.
Adoptive transfer of peripher
Adoptive transfer of peripher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4c719029f2594e3de695c532fce93e
http://europepmc.org/articles/PMC4925025
http://europepmc.org/articles/PMC4925025
Autor:
Ryan O. Emerson, Kendall C. Shibuya, David G. Coffey, Harlan Robins, Felecia Wagener, Philip D. Greenberg, Edus H. Warren, Cindy Desmarais, Jeffrey Chou, Cassian Yee, Ivy Lai, Thomas M. Schmitt, Ilana M. Roberts, Aude G. Chapuis
Adoptively transferred tumor-specific cells can mediate tumor regression in cancers refractory to conventional therapy. Autologous polyclonal tumor-specific cytotoxic T cells (CTL) generated from peripheral blood and infused into patients with metast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52dce37512b830a9740025bf3cb14688
https://europepmc.org/articles/PMC5371351/
https://europepmc.org/articles/PMC5371351/
Autor:
Upendra Parvathaneni, Ivy Lai, Cassian Yee, Kendall C. Shibuya, Paul Nghiem, Aude G. Chapuis, Kelly G. Paulson, Joo H a Hwang, Olga K. Afanasiev, Shailender Bhatia, Ilana M. Roberts, Jayasri G. Iyer, David M. Koelle, Cindy Desmarais, Ted Gooley, Heather L. Sloan
Publikováno v:
Cancer Immunology Research. 2:27-36
Merkel cell carcinoma (MCC) is an aggressive skin cancer that typically requires the persistent expression of Merkel cell polyomavirus (MCPyV) oncoproteins that can serve as ideal immunotherapeutic targets. Several immune evasion mechanisms are activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ac54ddbfb078f1f6c54ef9bed3e476
https://doi.org/10.1158/2326-6066.cir-13-0087
https://doi.org/10.1158/2326-6066.cir-13-0087
Autor:
Ilana M. Roberts, John A. Thompson, Kendall C. Shibuya, Jedd D. Wolchok, Ivy Lai, Aude G. Chapuis, Erik A. Farrar, Philip D. Greenberg, Shailender Bhatia, Felecia Wagener, Jianhong Cao, Kim Margolin, Cassian Yee, Heather L. Sloan, Sylvia Lee
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 34(31)
Purpose Peripheral blood–derived antigen-specific cytotoxic T cells (CTLs) provide a readily available source of effector cells that can be administered with minimal toxicity in an outpatient setting. In metastatic melanoma, this approach results i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c3d387dd417346348d32b404e41422
https://pubmed.ncbi.nlm.nih.gov/27269940
https://pubmed.ncbi.nlm.nih.gov/27269940
Autor:
John R. Wunderlich, Paul F. Robbins, Alena Gros, Anna Pasetto, Sadia Ilyas, Todd D. Prickett, Eric Tran, James Chih-Hsin Yang, Jessica S. Crystal, Kasia Trebska-Mcgowan, Maria R. Parkhurst, Steven A. Rosenberg, Ilana M. Roberts, Jared J. Gartner
Publikováno v:
Nat Med
Detection of lymphocytes that target tumor-specific mutant neoantigens—derived from products encoded by mutated genes in the tumor—is mostly limited to tumor-resident lymphocytes(1,2), but whether these lymphocytes often occur in the circulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056b1ba37a4641a49e50e4e75a057ddc
https://pubmed.ncbi.nlm.nih.gov/27050586
https://pubmed.ncbi.nlm.nih.gov/27050586
Autor:
Cassian Yee, Sylvia Lee, Ilana M. Roberts, Aude G. Chapuis, Ivy Lai, Philip D. Greenberg, Kim Margolin, Shailender Bhatia, John A. Thompson, David R. Byrd, Heather L. Sloan
Publikováno v:
Cancer Research. 73:PR11-PR11
Monotherapy with a blocking human anti-CTLA4 mAb achieves disease control in 20-28% of patients (pts), but failure to benefit in the remaining patients may reflect inadequate induction and/or expansion of melanoma reactive T cells following CTLA4 blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7997d6dfb33f22fc4b1c627a4f120448
https://doi.org/10.1158/1538-7445.tumimm2012-pr11
https://doi.org/10.1158/1538-7445.tumimm2012-pr11
Autor:
Olga K. Afanasiev, Ivy Lai, Ilana M. Roberts, Kelly G. Paulson, Kotaro Nagase, Aaron Seo, Erik A. Farrar, Paul Nghiem, Upendra Parvathaneni, Aude G. Chapuis, Joo Ha Hwang, Cassian Yee, David M. Koelle, Jayasri G. Iyer
Publikováno v:
Cancer Research. 73:IA17-IA17
Persistent expression of Merkel cell polyomavirus (MCPyV) T antigen oncoproteins is required for the growth of most Merkel cell carcinomas (MCCs). MCPyV oncoproteins are thus attractive tumor antigens for evaluating the feasibility of antigen-specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f353cd9bd8c24f583c192ae749f415a
https://doi.org/10.1158/1538-7445.tumimm2012-ia17
https://doi.org/10.1158/1538-7445.tumimm2012-ia17
Autor:
Ilana M. Roberts, Galina Pogosov, Jeff Pufnock, William Y. Ho, Colette Chaney, Hieu Nguyen, Natalie Duerkopp, Gunnar B. Ragnarsson, Philip D. Greenberg, Cassian Yee, Aude G. Chapuis, Jerald P. Radich, Merav Bar, Tomas Schmitt
Publikováno v:
Blood. 120:350-350
Abstract 350 Relapse is the leading cause of death following allogeneic hematopoietic cell transplant (HCT) for hematological malignancies. Although evidence suggests that the beneficial donor T cell-mediated graft versus leukemia (GVL) effect can re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4d31c09decfdeb510bf3afcc566b35c
https://doi.org/10.1182/blood.v120.21.350.350
https://doi.org/10.1182/blood.v120.21.350.350