Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ilana M Nodelman"'
Publikováno v:
eLife, Vol 7 (2018)
As superfamily 2 (SF2)-type translocases, chromatin remodelers are expected to use an inchworm-type mechanism to walk along DNA. Yet how they move DNA around the histone core has not been clear. Here we show that a remodeler ATPase motor can shift la
Externí odkaz:
https://doaj.org/article/e62dbc72c8e848209891939fe83cb5f7
Autor:
Ilana M. Nodelman, Sayan Das, Anneliese M. Faustino, Stephen D. Fried, Gregory D. Bowman, Jean-Paul Armache
Publikováno v:
Nat Struct Mol Biol
Chromatin remodelers are ATP-dependent enzymes that reorganize nucleosomes within all eukaryotic genomes. Here we report a complex of the Chd1 remodeler bound to a nucleosome in a nucleotide-free state, determined by cryo-electron microscopy (cryo-EM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce51e63c600b278b72e2556b4d1c3a97
https://doi.org/10.1038/s41594-021-00719-x
https://doi.org/10.1038/s41594-021-00719-x
Publikováno v:
Proc Natl Acad Sci U S A
Chromatin remodelers are ATP (adenosine triphosphate)-powered motors that reposition nucleosomes throughout eukaryotic chromosomes. Remodelers possess autoinhibitory elements that control the direction of nucleosome sliding, but underlying mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e92ad1c2032dcd85febf528eaed3380
https://doi.org/10.1073/pnas.2014498118
https://doi.org/10.1073/pnas.2014498118
Autor:
Gregory D. Bowman, Ilana M. Nodelman
Publikováno v:
Annu Rev Biophys
As primary carriers of epigenetic information and gatekeepers of genomic DNA, nucleosomes are essential for proper growth and development of all eukaryotic cells. Although intrinsically dynamic, nucleosomes are actively reorganized and replaced by AT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dbc321bb125529bcee9e33fe6cbe7e1
https://pubmed.ncbi.nlm.nih.gov/33395550
https://pubmed.ncbi.nlm.nih.gov/33395550
Publikováno v:
Curr Protoc Mol Biol
Nucleosomes are substrates for a broad range of factors, including those involved in transcription or chromosome maintenance/reorganization and enzymes that covalently modify histones. Given the heterogeneous nature of nucleosomes in vivo (i.e., vary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3130e653677903e20b3fd0ce19bb8f9
https://doi.org/10.1002/cpmb.130
https://doi.org/10.1002/cpmb.130
Autor:
Gregory D. Bowman, Elijah Roberts, Jessica Winger, Michelle D. Wang, Ilana M. Nodelman, Ren Ren, Ashok Kumar Patel, Robert F Levendosky, Ming Li, Kyle Horvath
Publikováno v:
Nucleic Acids Research
Chromatin remodelers are essential for establishing and maintaining the placement of nucleosomes along genomic DNA. Yet how chromatin remodelers recognize and respond to distinct chromatin environments surrounding nucleosomes is poorly understood. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799f8e1af43746b6f4f900fe8d1c9e30
http://europepmc.org/articles/PMC5027475
http://europepmc.org/articles/PMC5027475
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
As superfamily 2 (SF2)-type translocases, chromatin remodelers are expected to use an inchworm-type mechanism to walk along DNA. Yet how they move DNA around the histone core has not been clear. Here we show that a remodeler ATPase motor can shift la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c11602e8482166560a58848248ecee
https://elifesciences.org/articles/34100
https://elifesciences.org/articles/34100
Autor:
Ashok Kumar Patel, Gregory D. Bowman, Ren Ren, Ilana M. Nodelman, Kyle Horvath, Franziska Bleichert, James M. Berger
Chromatin remodelers use a helicase-like ATPase motor to reposition and reorganize nucleosomes along genomic DNA. Yet, how the ATPase motor communicates with other remodeler domains in the context of the nucleosome has so far been elusive. Here, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9892b6788dc4bc6278cd12279fd0541
https://europepmc.org/articles/PMC5308885/
https://europepmc.org/articles/PMC5308885/
Publikováno v:
Biophysical Journal. 116:502a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f78dcc28a75c8dbb75fb100726cafc8a
https://doi.org/10.1016/j.bpj.2018.11.2707
https://doi.org/10.1016/j.bpj.2018.11.2707