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pro vyhledávání: '"Ilana Agmon"'
Autor:
Ilana Agmon
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4960 (2024)
The evolution of the translation system is a fundamental issue in the quest for the origin of life. A feasible evolutionary scenario necessitates the autonomous emergence of a protoribosome capable of catalyzing the synthesis of the initial peptides.
Externí odkaz:
https://doaj.org/article/c4015fbab3364852aace5e374e3352b9
Autor:
Ilana Agmon
Publikováno v:
Life, Vol 14, Iss 2, p 277 (2024)
To track down the possible roots of life, various models for the initial living system composed of different combinations of the three extant biopolymers, RNA, DNA, and proteins, are presented. The suitability of each molecular set is assessed accord
Externí odkaz:
https://doaj.org/article/3edfc92284494539a7e6c79564cf8f18
Autor:
Ilana Agmon
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15756 (2022)
tRNA is a key component in life’s most fundamental process, the translation of the instructions contained in mRNA into proteins. Its role had to be executed as soon as the earliest translation emerged, but the questions of the prebiotic tRNA materi
Externí odkaz:
https://doaj.org/article/e65ebf6a890c4a3598a84e8fe4760731
Autor:
Ilana Agmon
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 12, p 4021 (2018)
The feasibility of self-assembly of a translation system from prebiotic random RNA chains is a question that is central to the ability to conceive life emerging by natural processes. The spontaneous materialization of a translation system would have
Externí odkaz:
https://doaj.org/article/bb3ed52f53b8453e86f031ad84915854
Autor:
Ilana Agmon
Publikováno v:
International Journal of Molecular Sciences, Vol 10, Iss 7, Pp 2921-2934 (2009)
A symmetric pocket-like entity, composed of two L-shaped RNA units, encircles the peptide synthesis site within the contemporary ribosome. This entity was suggested to be the vestige of a dimeric proto-ribosome, which could have formed spontaneously
Externí odkaz:
https://doaj.org/article/a456f16be0b44248b422737434e5c762
Autor:
Tanaya Bose, Gil Fridkin, Chen Davidovich, Miri Krupkin, Nikita Dinger, Alla H Falkovich, Yoav Peleg, Ilana Agmon, Anat Bashan, Ada Yonath
Publikováno v:
Nucleic Acids Research. 50:1815-1828
Although the mode of action of the ribosomes, the multi-component universal effective protein-synthesis organelles, has been thoroughly explored, their mere appearance remained elusive. Our earlier comparative structural studies suggested that a univ
Publikováno v:
FEBS lettersReferences. 595(7)
The mechanism and evolution of the recognition scheme between key components of the translation system, that is, tRNAs, synthetases, and elongation factors, are fundamental issues in understanding the translation of genetic information into proteins.
Autor:
Ilana Agmon
Publikováno v:
FEBS Letters. 591:3252-3258
A feasible scenario for the emergence of life requires the spontaneous materialization and sustainability of a proto-ribosome that could have catalysed the formation of the first peptides. Models of proto-ribosomes were derived from the ribosomal Pep
Autor:
Ilana Agmon, Tal Mor
Publikováno v:
Theory and Practice of Natural Computing ISBN: 9783319268408
TPNC
TPNC
In the conceptualization presented here, a possible scenario concerned with the emergence of coded life in nature is inferred from a model that merges computer science concepts with prebiotic chemistry. In this "digital" model, sets of strings compos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52da28e16a472a3590e405b28d1b3bfa
https://doi.org/10.1007/978-3-319-26841-5_8
https://doi.org/10.1007/978-3-319-26841-5_8
Publikováno v:
Biological Chemistry. 386:833-844
The sizable symmetrical region, comprising 180 ribosomal RNA nucleotides, which has been identified in and around the peptidyl transferase center (PTC) in crystal structures of eubacterial and archaeal large ribosomal subunits, indicates its universa