Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ilan Elson-Schwab"'
Publikováno v:
PLoS ONE, Vol 5, Iss 10 (2010)
A functional role of microRNAs (miRNAs or miRs) in neoplasia and metastasis is becoming clear, and the miR-200 family has received much attention for potentially regulating tumor progression. The miRNAs of this family have been shown to suppress epit
Externí odkaz:
https://doaj.org/article/c073abbaf2df48019063abc2091e36fd
Autor:
Vikram Khurana, Ilan Elson-Schwab, Tudor A Fulga, Katherine A Sharp, Carin A Loewen, Erin Mulkearns, Jaana Tyynelä, Clemens R Scherzer, Mel B Feany
Publikováno v:
PLoS Genetics, Vol 6, Iss 7, p e1001026 (2010)
Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's dise
Externí odkaz:
https://doaj.org/article/aac121ca1623427eb049dd57cbdfc71c
Publikováno v:
Journal of Cell Science. 124:1256-1267
Melanoma cells can switch between an elongated mesenchymal-type and a rounded amoeboid-type migration mode. The rounded ‘amoeboid’ form of cell movement is driven by actomyosin contractility resulting in membrane blebbing. Unlike elongated A375 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b01756203e6e5b416c7da15bcf5da1d
https://doi.org/10.1242/jcs.074849
https://doi.org/10.1242/jcs.074849
Publikováno v:
The Journal of Immunology. 173:3186-3192
Folate is required for one-carbon transfer reactions and the formation of purines and pyrimidines for DNA and RNA synthesis. Deficiency of folate can lead to many clinical abnormalities, including macrocytic anemia, cardiovascular diseases, birth def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3091a46a1dcc00c06b909ea83a50c3cd
https://doi.org/10.4049/jimmunol.173.5.3186
https://doi.org/10.4049/jimmunol.173.5.3186
Autor:
Bee Lan Lee, Choon Nam Ong, Chantal Courtemanche, Michael Fenech, Susan T. Mashiyama, Bruce N. Ames, Ilan Elson-Schwab, Jimmy W. Crott
Publikováno v:
Analytical Biochemistry. 330:58-69
Folate deficiency leads to increased dUMP/dTMP ratios and uracil misincorporation into DNA, which may increase cancer risk. We improved a previously described gas chromatography-mass spectrometry (GC-MS) assay for uracil in DNA and validated the assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0aba32f9e23c9fa4851bfa855abaee
https://doi.org/10.1016/j.ab.2004.03.065
https://doi.org/10.1016/j.ab.2004.03.065
Publikováno v:
PLoS ONE, Vol 5, Iss 10 (2010)
PLoS ONE
PLoS ONE
Background: A functional role of microRNAs (miRNAs or miRs) in neoplasia and metastasis is becoming clear, and the miR200 family has received much attention for potentially regulating tumor progression. The miRNAs of this family have been shown to su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce50d912d782c59950ca13b74ad5a01b
http://europepmc.org/articles/PMC2949394?pdf=render
http://europepmc.org/articles/PMC2949394?pdf=render
Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison
Autor:
Chantal Courtemanche, Bernice Y. Ng, Bruce N. Ames, Arnold C. Huang, Nicole Kerry, Ilan Elson-Schwab
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18(1)
DNA double-strand breaks, the most serious DNA lesion caused by ionizing radiation, are also caused by several vitamin or mineral deficiencies, such as for folate. Primary human lymphocytes were either irradiated or cultured at different levels of fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3933c041274490daa7f4ef31cabae745
https://pubmed.ncbi.nlm.nih.gov/14597554
https://pubmed.ncbi.nlm.nih.gov/14597554
Publikováno v:
The American journal of clinical nutrition. 75(4)
As many as one-third of mutations in a gene result in the corresponding enzyme having an increased Michaelis constant, or K(m), (decreased binding affinity) for a coenzyme, resulting in a lower rate of reaction. About 50 human genetic dis-eases due t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74589c824ebb203dd9912f73508034b3
https://pubmed.ncbi.nlm.nih.gov/11916749
https://pubmed.ncbi.nlm.nih.gov/11916749
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 97(21)
Cyclooxygenase-2 (COX-2)-catalyzed synthesis of prostaglandin E 2 (PGE 2 ) plays a key role in inflammation and its associated diseases, such as cancer and vascular heart disease. Here we report that γ-tocopherol (γT) reduced PGE 2 synthesis in bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ca3eaca1f7ae03a06e8447f0dce503
https://pubmed.ncbi.nlm.nih.gov/11005841
https://pubmed.ncbi.nlm.nih.gov/11005841
Autor:
Carin A. Loewen, Katherine A. Sharp, Jaana Tyynelä, Vikram Khurana, Clemens R. Scherzer, Erin E. Mulkearns, Mel B. Feany, Ilan Elson-Schwab, Tudor A. Fulga
Publikováno v:
PLoS Genetics, Vol 6, Iss 7, p e1001026 (2010)
PLoS Genetics
PLoS Genetics
Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79630aaec073619fd2408c0bb765efec
https://doi.org/10.1371/journal.pgen.1001026
https://doi.org/10.1371/journal.pgen.1001026