Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ilakya Selvarajan"'
Autor:
Ashik Jawahar Deen, Simone Adinolfi, Jouni Härkönen, Tommi Patinen, Xiaonan Liu, Tuomo Laitinen, Piia Takabe, Kirsi Kainulainen, Sanna Pasonen-Seppänen, Lisa M. Gawriyski, Uma Thanigai Arasu, Ilakya Selvarajan, Petri Mäkinen, Hanna Laitinen, Emilia Kansanen, Minna U. Kaikkonen, Antti Poso, Markku Varjosalo, Anna-Liisa Levonen
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 103031- (2024)
The Kelch-like ECH-associated protein 1 (KEAP1) – Nuclear factor erythroid 2 -related factor 2 (NRF2) pathway is the major transcriptional stress response system in cells against oxidative and electrophilic stress. NRF2 is frequently constitutively
Externí odkaz:
https://doaj.org/article/6424cb4692934e1e8076ab053da688af
Autor:
Nicholas Darci-Maher, Marcus Alvarez, Uma Thanigai Arasu, Ilakya Selvarajan, Seung Hyuk T. Lee, David Z. Pan, Zong Miao, Sankha Subhra Das, Dorota Kaminska, Tiit Örd, Jihane N. Benhammou, Martin Wabitsch, Joseph R. Pisegna, Ville Männistö, Kirsi H. Pietiläinen, Markku Laakso, Janet S. Sinsheimer, Minna U. Kaikkonen, Jussi Pihlajamäki, Päivi Pajukanta
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104620- (2023)
Summary: Background: Non-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed, epidemic. We hypothesise that obesity-related inflammation compromises adipose tissue functions, preventing efficient fat storage, and thus driving ecto
Externí odkaz:
https://doaj.org/article/d790980f12064df98a63142b4ca4e5bb
Autor:
Jouni Härkönen, Petri Pölönen, Ashik Jawahar Deen, Ilakya Selvarajan, Hanna-Riikka Teppo, Elitsa Y. Dimova, Thomas Kietzmann, Maarit Ahtiainen, Juha P. Väyrynen, Sara A. Väyrynen, Hanna Elomaa, Niko Tynkkynen, Tiia Eklund, Teijo Kuopio, Eva-Maria Talvitie, Pekka Taimen, Markku Kallajoki, Minna U. Kaikkonen, Merja Heinäniemi, Anna-Liisa Levonen
Publikováno v:
Redox Biology, Vol 61, Iss , Pp 102644- (2023)
The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive analysis of its effects across different malignancies is currently lacking. We developed a NRF2 activity metric and utilized it to conduct a pan-cancer analysis of
Externí odkaz:
https://doaj.org/article/9ac1335b051440bd822ee925a02cdeed
Autor:
Nicholas Darci-Maher, Marcus Alvarez, Uma Thanigai Arasu, Ilakya Selvarajan, Seung Hyuk T. Lee, David Z. Pan, Zong Miao, Sankha Subhra Das, Dorota Kaminska, Tiit Örd, Jihane N. Benhammou, Martin Wabitsch, Joseph R. Pisegna, Ville Männistö, Kirsi H. Pietiläinen, Markku Laakso, Janet S. Sinsheimer, Minna U. Kaikkonen, Jussi Pihlajamäki, Päivi Pajukanta
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed, epidemic. We hypothesise that obesity-related inflammation compromises adipose tissue functions, preventing efficient fat storage, and thus driving ectopic fat acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e978e5c7684af3edcace9dcec0d5b474
https://escholarship.org/uc/item/29h649mt
https://escholarship.org/uc/item/29h649mt
Autor:
Ilakya Selvarajan, Jin Li, Petri Pölönen, Tiit Örd, Kadri Õunap, Aarthi Ravindran, Kiira Mäklin, Anu Toropainen, Lindsey K. Stolze, Stephen White, Casey E. Romanoski, Merja Heinäniemi, Yun Fang, Minna Kaikkonen-Määttä
Coronary artery disease (CAD) is one of the major causes of mortality worldwide. Recent genome-wide association studies have started to unravel the genetic architecture of the disease. Such efforts have identified Calcitonin receptor-like (CALCRL), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e151be10fc3938e1c28e80d8eaa4bb9
https://doi.org/10.1101/2023.02.08.527795
https://doi.org/10.1101/2023.02.08.527795
Autor:
Jouni Härkönen, Petri Pölönen, Ashik Jawahar Deen, Ilakya Selvarajan, Hanna-Riikka Teppo, Elitsa Y Dimova, Thomas Kietzmann, Maarit Ahtiainen, Tiia Eklund, Teijo Kuopio, Eva-Maria Talvitie, Pekka Taimen, Markku Kallajoki, Minna U Kaikkonen, Merja Heinäniemi, Anna-Liisa Levonen
SummaryThe NRF2 pathway is frequently activated in various cancer types, yet a comprehensive analysis of its effects across different malignancies is currently lacking. We developed a robust NRF2 activity metric and utilized it to conduct a pan-cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cb17c261efbbe564c455cb72310b1fc
https://doi.org/10.1101/2022.05.15.489654
https://doi.org/10.1101/2022.05.15.489654
Autor:
Anu Toropainen, Sami Heikkinen, Anna-Liisa Levonen, Ville Männistö, Jussi Pihlajamäki, Dorota Kaminska, Maykel López Rodríguez, Päivi Pajukanta, Tiit Örd, Casey E. Romanoski, Kristina M. Garske, Ashik Jawahar Deen, Minna U. Kaikkonen, Zong Miao, Aldons J. Lusis, Ilakya Selvarajan, Arthur Ko, Kadri Õunap, Oscar Hsin-Fu Liu, Calvin Pan, Pierre Moreau, Aarthi Ravindran
Publikováno v:
Am J Hum Genet
The American Journal of Human Genetics
The American Journal of Human Genetics
Genetic factors underlying coronary artery disease (CAD) have been widely studied using genome-wide association studies (GWASs). However, the functional understanding of the CAD loci has been limited by the fact that a majority of GWAS variants are l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79be5c2294d70f87f28cfc9b023ad559
https://europepmc.org/articles/PMC8008493/
https://europepmc.org/articles/PMC8008493/
Autor:
Juho J Pajula, Oscar Hsin-Fu Liu, Pierre Moreau, Pasi Tavi, Einari Aavik, Tiia A. Turunen, Seppo Ylä-Herttuala, Tomi Tuomainen, Minna U. Kaikkonen, Paavo Halonen, Ilakya Selvarajan
Publikováno v:
Circulation: Cardiovascular Genetics. 10
Background— Microarrays and RNA sequencing are widely used to profile transcriptome remodeling during myocardial ischemia. However, the steady-state RNA analysis lacks in sensitivity to detect all noncoding RNA species and does not provide separati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491ce879bd1e7dc742a3938b3c8ab25a
https://doi.org/10.1161/circgenetics.117.001702
https://doi.org/10.1161/circgenetics.117.001702
Autor:
Minna U. Kaikkonen, Paavo Halonen, Oscar Hsin-Fu Liu, Tiia A. Turunen, Juho Pajula, Pierre Moreau, Ilakya Selvarajan, Tomi Tuomainen, Einari Aavik, Pasi Tavi, Seppo Ylä-Herttuala
Publikováno v:
Circulation: Cardiovascular Genetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::3aa52a600c214ee45a1a995b9d811df6
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