Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ila, Sircar"'
Autor:
Madhavi Pannala, Sunil Kher, Ila Sircar, Rick Jack, Kirk Lake, Shao-Hui Zhang, James Zapf, Lisa Morera, Juping Liu, Kui Xu, Farid Bakir, Jie-Fei Cheng, Naoki Sakurai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4442-4446
Structure-activity relationship studies on a series of Boc-indole derivatives as LXR agonists are described. Compound 1 was identified as an LXR agonist through structure-based virtual screening followed by high-throughput gene profiling. Replacement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b33d8f8884334c3855313d44722c5fe
https://doi.org/10.1016/j.bmcl.2007.06.017
https://doi.org/10.1016/j.bmcl.2007.06.017
Autor:
Ila Sircar, Chiaki Fukushima, Lisa Schneider, James Zapf, Madhavi Pannala, Lisa Morera, Trang Nguyen, Jie-Fei Cheng, Rick Jack, Norma Wilson, Shao-Hui Zhang, Kui Xu, Farid Bakir, Juping Liu, Kei Takedomi, Naoki Sakurai, Sunil Kher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3473-3479
A structurally novel liver X receptor (LXR) agonist (1) was identified from internal compound collection utilizing the combination of structure-based virtual screening and high-throughput gene profiling. Compound 1 increased ABCA1 gene expression by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7eb508e31f7c0f8a1fb69a6abab291c
https://doi.org/10.1016/j.bmcl.2007.03.076
https://doi.org/10.1016/j.bmcl.2007.03.076
Autor:
Ila Sircar, Sumihiro Nomura, Bradley Teegarden, Dawn M. Nowlin, Jason R Mah, Griffith Ronald C, Samuel Connell, Honnappa Jayakumar, Kristjan S. Gudmundsson, Elias Lazarides, Pina M. Cardarelli, Richard Martin, Jimmy Liang
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:2051-2066
alpha(4)beta(1) and alpha(4)beta(7) integrins are key regulators of physiologic and pathologic responses in inflammation and autoimmune disease. The effectiveness of anti-integrin antibodies to attenuate a number of inflammatory/immune conditions pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8f85d85089696b745ea8a723445a8a3
https://doi.org/10.1016/s0968-0896(02)00021-4
https://doi.org/10.1016/s0968-0896(02)00021-4
Autor:
John C. Hodges, Sylvester Klutchko, Quin J rd, James M. Hamby, C. J. C. Connolly, Amy Mae Bunker, Jeremy J. Edmunds, Panek Rl, Ila Sircar, R. T. Winters
Publikováno v:
Journal of Medicinal Chemistry. 38:3759-3771
A series of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins have been prepared and evaluated as in vitro and in vivo angiotensin II (Ang II) antagonists. Variation of substituents on the hydantoin ring leads to potent and selective Ang II a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8577ad9ea2cc526f50e8f2e3bc3f0f3a
https://doi.org/10.1021/jm00019a005
https://doi.org/10.1021/jm00019a005
Autor:
C. R. Kostlan, R. T. Winters, Jeremy J. Edmunds, John C. Hodges, S. J. Kesten, Quin J rd, Ila Sircar, Amy Mae Bunker, C. J. C. Connolly, James M. Hamby
Publikováno v:
Journal of Medicinal Chemistry. 36:2253-2265
A novel series of nonpeptide angiotensin II (AII) receptor antagonists containing a 1H-pyrrol-1-yl moiety at the 4-position of the imidazole have been developed. The pyrrole group occupies the same lipophilic pocket at the receptor as the chloro grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ed13349ecd9dbf8ef3bacf18dc4fdd9
https://doi.org/10.1021/jm00068a002
https://doi.org/10.1021/jm00068a002
Publikováno v:
Journal of Medicinal Chemistry. 36:1735-1745
A novel series of non-biphenylyltetrazole angiotensin II receptor antagonists which contain a 1H-pyrrol-1-ylacetyl residue in place of the benzoyl residue in EXP 6803 have been developed. The receptor binding activity of several members of this new s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99245e897485eb0fbe7359139bb20545
https://doi.org/10.1021/jm00064a007
https://doi.org/10.1021/jm00064a007
Autor:
Ila Sircar, M. D. Taylor, Thomas A. Pugsley, Ronald E. Weishaar, Yu-Hsin Shih, K. R. Anderson, S. J. Haleen, R. P. Steffen, E. K. Gregor
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8e9a291c94f54d9db4d08a9fe6bd9ab
https://doi.org/10.1002/chin.199152207
https://doi.org/10.1002/chin.199152207
Autor:
Amy Mae Bunker, Ila Sircar, James Marino Hamby, Joan A. Keiser, J. Iii Quin, C. R. Kostlan, John C. Hodges, Jeremy J. Edmunds, Robert L. Panek, S. J. Kesten, J. G. Topliss, R. T. Winters, C. J. C. Connolly
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6da5b8d9e457283c3ba66d1c1cc99cb4
https://doi.org/10.1002/chin.199352180
https://doi.org/10.1002/chin.199352180
Autor:
R. T. Winters, Jeremy J. Edmunds, Joan A. Keiser, Robert L. Panek, C. J. C. Connolly, Amy Mae Bunker, J. Quinn, James Marino Hamby, Sylvester Klutchko, Annette Marian Doherty, Ila Sircar, John C. Hodges
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b0786198f9d96deb74e75aebdca9f8e
https://doi.org/10.1002/chin.199603129
https://doi.org/10.1002/chin.199603129
Autor:
Ila Sircar, Thomas A. Pugsley, Yu Hsin Shih, Michael Taylor, Eva K. Gregor, Stehen J. Haleen, Kevin R. Anderson, R. P. Steffen, Ronald E. Weishaar
Publikováno v:
Journal of Medicinal Chemistry. 34:2248-2260
The synthesis and pharmacological evaluation of a series of 2-[(arylsulfonyl)methyl]-4-aryl-5-cyano-1,4-dihydropyridine-3-carboxylic acid esters and analogues are described. These compounds possess a unique profile namely, calcium channel blocking an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb893dc64e6f363c1f4242efd92ae0e
https://doi.org/10.1021/jm00111a047
https://doi.org/10.1021/jm00111a047