Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Il-Whea Ku"'
Autor:
Young Ha Kim, Il-Whea Ku, Kwangwoo Chun, Kang-Jeon Kim, Seung Hyun Kim, Goang-Won Cho, Han-Chang Lee, In-Hea Ye, Jeong-Min Kim, Ji-Seon Park, Heejaung Kim, Min Young Noh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3983-3987
New potent glycogen synthase kinase-3 (GSK-3) inhibitors, 8-amino-[1,2,4]triazolo[4,3- a ]pyridin-3(2 H )-one derivatives, were designed by modeling, synthesized and evaluated in vitro . Compound 17c showed good potency in enzyme and cell-based assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9e8add171486d72d8590aaf7e9ffe9
https://doi.org/10.1016/j.bmcl.2013.03.119
https://doi.org/10.1016/j.bmcl.2013.03.119
Autor:
Byung Yong Kang, Yoon-Ho Hong, Min Young Noh, Goang-Won Cho, Seung Hyun Kim, Ji-Seon Park, Il-Whea Ku, Myung-Hwa Kim
Publikováno v:
ASSAY and Drug Development Technologies. 9:503-513
Glycogen synthase kinase-3β (GSK-3β), a serine/threonine kinase also known as tau protein kinase I, has been implicated in the pathogenic conditions of Alzheimer's disease. Many investigators have focused on GSK-3 inhibitor as a therapeutic drug. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e2436ea637025cfc67c372b6105459
https://doi.org/10.1089/adt.2010.0343
https://doi.org/10.1089/adt.2010.0343
Publikováno v:
Bulletin of the Korean Chemical Society. 32:3167-3170
E-mail: gkeum@kist.re.krReceived April 20, 2011, Accepted April 22, 2011Key Words : Ugi reaction, Multicomponent reaction, Piracetam, Nootropics, Lactam The Ugi four-component condensation reaction have beenwidely used for the construction of focused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1139e170ac0feef9b2200b428800c78d
https://doi.org/10.5012/bkcs.2011.32.8.3167
https://doi.org/10.5012/bkcs.2011.32.8.3167
Autor:
Il Whea Ku, Han Chang Lee, Jong Hee Choi, Myung Hwa Kim, Hyun Young Kim, Seung Hyun Kim, Kwangwoo Chun, Goang Won Cho, Bo Young Joe, Seong-Ho Koh, Chun Ho Park
Publikováno v:
Medicinal Chemistry Research. 21:1533-1543
A series of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors, 5-oxo-2,4,5,6-tetrahydro-1H-thiopyrano[3,4-c]quinoline-9-carboxamide derivatives, were successfully synthesized and their PARP-1 inhibitory activity was evaluated. These compounds were pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::861fc85de91083f9ba9192b89793f5cc
https://doi.org/10.1007/s00044-011-9673-6
https://doi.org/10.1007/s00044-011-9673-6
Autor:
Ji-Eun Kim, Yoon Sun Park, Joseph Kim, Sang Soo Park, Mi Jin Kim, Hyebin Park, Jae-Sik Shin, Joonyee Jung, Hyun Ho Lee, Jai-Hee Moon, Hyo-Jin Kim, Jun Ki Hong, Sun-Chul Hur, Dong-Hoon Jin, Il-Whea Ku, Chun-Ho Park, So-Hee Lee, Dae-Hee Lee, Ji Hee Gong, Seungwoo Hong
Publikováno v:
Cancer Research. 78:2909-2909
Lung cancer is second most common cancer in the world. Non Small Cell Lung Cancer (NSCLC) accounts approximately 80-85% of all lung cancer diagnosis. Traditional therapies of this disease were surgical resection, chemotherapy, and radiotherapy, alone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc5156f0ffd2ae54151f6e4cda7b2912
https://doi.org/10.1158/1538-7445.am2018-2909
https://doi.org/10.1158/1538-7445.am2018-2909
Autor:
Hyo-Jin Kim, Jun Ki Hong, Ji-Eun Kim, Seungwoo Hong, Jai-Hee Moon, Yoon Sun Park, Joonyee Jung, So-Hee Lee, Hyebin Park, Chun-Ho Park, Dong-Hoon Jin, Il-Whea Ku, Hyun Ho Lee, Sang Soo Park, Joseph Kim, Jae-Sik Shin, Dae-Hee Lee, Sun-Chul Hur, Ji Hee Gong, Mi Jin Kim
Publikováno v:
Cancer Research. 78:2669-2669
As the representative targeted anticancer drug for colon cancer patients, Erbitux is the EGFR targeted therapeutic antibody and used for treatment of KRAS wild-type colon cancer patients. Even some patients with KRas wt gene did not respond to Erbitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa043ac60116ed4002daf9b888afa91f
https://doi.org/10.1158/1538-7445.am2018-2669
https://doi.org/10.1158/1538-7445.am2018-2669
Autor:
Soon Bang Kang, Gyochang Keum, Youseung Kim, Bong Young Chung, Munikumar Reddy Doddareddy, Sangwon Cho, Hyewhon Rhim, Min Seok Jang, Il Whea Ku, Jung-Ha Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5244-5248
Morpholin-2-one-5-carboxamide derivatives were prepared by using the one-pot Ugi multicomponent reaction and evaluated for blocking effects on T- and N-type Ca(2+) channels. Among them, compound 5i produced the highest potency (IC(50)=0.45+/-0.02 mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494c25b91675e258e890c87c3fa87b9f
https://doi.org/10.1016/j.bmcl.2006.05.031
https://doi.org/10.1016/j.bmcl.2006.05.031
Autor:
Soon Bang Kang, Taeg-Su Jang, Bong Young Chung, Gyochang Keum, Youseung Kim, Min Seok Jang, Il Whea Ku
Publikováno v:
Organic Letters. 8:195-198
[reaction: see text] A new and efficient indium-mediated one-pot three-component reaction for the synthesis of N-aryl-substituted homoallylamines from aromatic amines, enol ethers, and allylic bromides in THF at room temperature is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cb5e1b63f823ab89d7e247d86ccf26
https://doi.org/10.1021/ol052326o
https://doi.org/10.1021/ol052326o
Autor:
Goang-Won Cho, Min-Young Noh, Byung Yong Kang, Il-Whea Ku, Jiseon Park, Yoon-Ho Hong, Myung-Hwa Kim, Seung Hyun Kim
Publikováno v:
Assay & Drug Development Technologies; Oct2011, Vol. 9 Issue 5, p503-513, 11p