Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Ikuo Yamashina"'
Autor:
Minoru Okayama, Yuri Kusano, Masae Tatematsu, Ikuo Yamashina, Seiichi Munesue, Kayoko Oguri, Hayao Nakanishi, Yasuo Yoshitomi
Publikováno v:
Cancer Letters. 207:165-174
Heparin, a widely used anticoagulant, is known to have anti-metastatic activity, although the mechanism is not fully understood. In the present study, we investigated the mechanism of this anti-metastatic activity using periodate-oxidized and borohyd
Autor:
Seiichi MUNESUE, Yuri KUSANO, Kayoko OGURI, Naoki ITANO, Yasuo YOSHITOMI, Hayao NAKANISHI, Ikuo YAMASHINA, Minoru OKAYAMA
Publikováno v:
Biochemical Journal. 363:201-209
Syndecans, a family of transmembrane heparan sulphate proteoglycans, contribute to various biological processes, including adhesion, motility, proliferation, differentiation and morphogenesis. We document here the involvement of syndecan-2 acting alo
Autor:
Kaoru Akita, Hiroshi Nakada, Mizue Inoue, Minoru Okayama, Seiichi Munesue, Kayoko Oguri, Ikuo Yamashina, Takahiro Fujimoto, Shinji Fushiki
Publikováno v:
Cell Structure and Function. 26:271-278
We isolated glycoproteins carrying the Tn antigen, which was expressed spatiotemporally in the developing mouse brain. The Tn antigen was expressed on two molecular species with a molecular weight from 200 to 350 kDa and 110 to 160 kDa, as judged on
Autor:
Ikuo Yamashina, Tsuneo Saga, Zhengsheng Yao, Harumi Sakahara, Hiroshi Nakada, Noriko Sato, Junji Konishi, Hisashi Onodera, Meili Zhang, Keigo Endo, Yuji Nakamoto
Publikováno v:
Japanese Journal of Cancer Research : Gann
Although development of human anti-murine immunoglobulin antibody (HAMA) is often seen in patients receiving murine antibodies, the variety of methods used for detecting HAMA makes it difficult to compare directly the HAMA responses measured by diffe
Publikováno v:
Biochemical and Biophysical Research Communications. 234:559-563
Mucin-type glycoproteins carrying sialylLeA antigens (SL-GP) were isolated from the ascites fluid of a patient with colorectal cancer. SL-GP bound to E-selectin on endothelial cells in Ca2+- and sialylLeA antigen-dependent manners. To examine the met
Publikováno v:
Glycoconjugate Journal. 14:147-153
Novel glycoproteins carrying sialyl-LeA (SLeA) antigens (SL-GP) were isolated from ascites fluid from a patient with colorectal cancer by immunoaffinity chromatography. Their characteristics, including binding capacity to E-selectin, were investigate
Publikováno v:
Glycoconjugate Journal. 12:356-359
We have measured glycosyltransferase activities of SupT1 cells, a T-lymphoid cell line shown to react with autoantibodies in the sera of many HIV patients. Since considerable alpha-N-acetylgalactosaminyl-transferase and beta 1, 3 galactosyltransferas
Autor:
Hiroshi Nakada, Ikuo Yamashina, Harumi Sakahara, Takashi Imamura, Gakuji Ohshio, Masayuki Imamura, Hirohiko Yamabe
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 121:247-252
Alterations in the normal glycosylation process are often associated with oncogenic transformation. Using an anti-Tn monoclonal antibody, MLS128, we have investigated the immunohistochemical localization of Tn antigen in normal and malignant tissues
Autor:
Mizue Inoue, Ikuo Yamashina, Masayuki Imamura, Harumi Sakahara, Gakuji Ohshio, Hideyuki Yoshioka, Tadao Manabe, Nobuhiro Tanaka, Hirohiko Yamabe, Hiroshi Nakada
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 120:325-330
Oncogenic transformation is often associated with changes in the glycosylation state of malignant cells. We investigated the immunohistochemical localization of sialosyl-Tn antigen [O-linked NeuAc(alpha 2-->6)GAINAc] using a novel monoclonal antibody