Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Ikuo Norota"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 120, Iss 4, Pp 264-269 (2012)
Understanding the regulation of cardiac ion channels is critical for the prevention of arrhythmia caused by abnormal excitability. Ion channels can be regulated by a change in function (qualitative) and a change in number (quantitative). Functional c
Externí odkaz:
https://doaj.org/article/d6689b40d35c4d5c84f8cb55bc87ecb2
Publikováno v:
Journal of Pharmacological Sciences, Vol 109, Iss 2, Pp 193-202 (2009)
Endothelin-1 (ET-1) modulates cardiac contractility by cross-talk with norepinephrine (NE) in canine ventricular myocardium. The present experiments were performed to investigate the influence of wortmannin that has inhibitory action on phosphatidyli
Externí odkaz:
https://doaj.org/article/1793d12ba2404a3a9f0e55b34b14b074
Publikováno v:
Journal of Pharmacological Sciences, Vol 97, Iss 3, Pp 417-428 (2005)
In canine ventricular myocardium, endothelin-1 (ET-1) alone induced only a weak transient negative inotropic effect (NIE). However, ET-1 induced a marked sustained positive inotropic effect (PIE) subsequent to a transient NIE in the presence of norep
Externí odkaz:
https://doaj.org/article/3329cb0ad6d14b79b033d1c3f31d7c16
Publikováno v:
Journal of Pharmacological Sciences, Vol 96, Iss 2, Pp 199-207 (2004)
Endothelin-1 (ET-1), angiotensin II (Ang II), and phenylephrine, an α2-adrenoceptor agonist, share the common signaling process, resulting in activation of Gq protein-coupled receptor (GqPCR) to activate the hydrolysis of phosphoinositide (PI). They
Externí odkaz:
https://doaj.org/article/46591639809548739ddc92ac080fd3d6
Autor:
Fumiaki, Nasu, Yutaro, Obara, Yosuke, Okamoto, Hiroaki, Yamaguchi, Kazuya, Kurakami, Ikuo, Norota, Kuniaki, Ishii
Publikováno v:
Life sciences. 269
Azelnidipine, a third-generation dihydropyridine calcium channel blocker (DHP CCB), has a characteristic hypotensive effect that persists even after it has disappeared from the plasma, which is thought to be due to its high hydrophobicity. However, b
Autor:
Hiroko Izumino, Yosuke Sudo, Hiroko Sato, Gen Tamiya, Yoshitaka Takahashi, Ikuo Norota, Kiyoshi Hayasaka, Kuniaki Ishii, Tetsuo Mitsui, Yuki Kawakami, Satoshi Makino, Toru Meguro
Publikováno v:
Journal of human genetics. 66(8)
The arachidonic acid (AA) cascade plays a significant role in platelet aggregation. AA released from membrane phospholipids is metabolized by cyclooxygenase (COX) pathway to thromboxane A2 (TXA2) or by 12S-lipoxygenase (ALOX12) to 12-hydroperoxyeicos
Autor:
Kazuya, Kurakami, Ikuo, Norota, Fumiaki, Nasu, Shingo, Ohshima, Yoshinobu, Nagasawa, Yoshihiro, Konno, Yutaro, Obara, Kuniaki, Ishii
Publikováno v:
Biochemical pharmacology. 169
KCNQ1 (Kv7.1 or KvLQT1) plays important physiological roles in various tissues forming potassium channels with KCNE subunits. Among the channels formed by KCNQ1 and KCNE subunits, the best studied is the slow delayed rectifier potassium channel in th
Autor:
Ikuo Norota, Kazuya Kurakami, Hiroaki Yamaguchi, Fumiaki Nasu, Yosuke Okamoto, Yutaro Obara, Kuniaki Ishii
Publikováno v:
Life Sciences. 269:119043
Aims Azelnidipine, a third-generation dihydropyridine calcium channel blocker (DHP CCB), has a characteristic hypotensive effect that persists even after it has disappeared from the plasma, which is thought to be due to its high hydrophobicity. Howev
Autor:
Kuniaki Ishii, Yoshihiro Konno, Yoshinobu Nagasawa, Shingo Ohshima, Yutaro Obara, Kazuya Kurakami, Fumiaki Nasu, Ikuo Norota
Publikováno v:
Biochemical Pharmacology. 169:113628
KCNQ1 (Kv7.1 or KvLQT1) plays important physiological roles in various tissues forming potassium channels with KCNE subunits. Among the channels formed by KCNQ1 and KCNE subunits, the best studied is the slow delayed rectifier potassium channel in th
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 371:185-194
The role of Rho kinase activation in the regulation of cardiac contractility and Ca(2+) signaling remains unclear, whereas its role in smooth muscle regulation has been well documented. To study the potential role of Rho kinase in the regulation of c