Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Ikuo Iijima"'
Autor:
Masanori Inamasu, Hidenori Akatsuka, Masakatsu Ozeki, Mamoru Matsumoto, Yutaka Saiga, Saburo Kawanami, Kunihito Okumura, Kenji Arakawa, Ikuo Iijima, Koichi Homma, Akishige Watanabe, Kosuke Yasuda
Publikováno v:
Chemical and Pharmaceutical Bulletin. 45:1984-1993
A new series of benzoxazole 2,4-thiazolidinediones was synthesized and evaluated for hypoglycemic activity in genetically obese and diabetic yellow KK mice. 2-Arylmethyl- and 2-(heteroarylmethyl)benzoxazole derivatives showed far more potent activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde1265dcabd844cb105548e3b230f0c
https://doi.org/10.1248/cpb.45.1984
https://doi.org/10.1248/cpb.45.1984
Publikováno v:
Journal of Pharmacobio-Dynamics. 10:599-607
The effects of oral administration of methyl (+)(3S)-1,2,3,4-tetrahydro-3-hydroxymethyl-beta-carboline-2-carbodith ioate (THC) on acute liver injuries induced by carbon tetrachloride (CCl4), bromobenzene (B.B.), D-galactosamine (GALN) and alpha-napht
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f7ab1e8bdeb1b4ed6e14e1dcd49620
https://doi.org/10.1248/bpb1978.10.599
https://doi.org/10.1248/bpb1978.10.599
Autor:
Shosui Matsushima, Ikuo Iijima, Goro Okamura, Kazuo Kurosawa, Takako Yokoyama, Shoichi Miyazawa, Noriko Sasaki, Masaru Asada
Publikováno v:
JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE. 36:96-105
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8a3bfe82f4b57b5e72c44ded86de340
https://doi.org/10.2185/jjrm.36.96
https://doi.org/10.2185/jjrm.36.96
Publikováno v:
Chemical and Pharmaceutical Bulletin. 23:2573-2577
Hydrolytic cyclization of 2-acyl-(2-cyanoethyl) succinates (Ib, c) was found to give 2, 3, 3a, 4, 5, 6-hexahydroindole-2, 6-diones (IIb, c), which readily yielded 6-hydroxyoxindoles (III) by dehydrogenation. Four-step synthesis of the erythrinane ske
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9427e1ebc0c2a46e95408a416aaa08df
https://doi.org/10.1248/cpb.23.2573
https://doi.org/10.1248/cpb.23.2573
Autor:
Tokuro Oh-Ishi, Ikuo Iijima, Toshikazu Miyagishima, Akihiko Ishida, Koichi Homma, Yutaka Saiga, Mamoru Matsumoto, Yuzo Matsuoka
Publikováno v:
Chemical and Pharmaceutical Bulletin. 35:3284-3291
Dithiocarbamates of various substituted tetrahydro-β-carbolines were synthesized and tested for hepatoprotective activity against carbon tetrachloride (CCl4) -induced liver damage in mice. Structure-activity relationships were investigated. Some nei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f790054db69a48c75bd7ed60d76ef61
https://doi.org/10.1248/cpb.35.3284
https://doi.org/10.1248/cpb.35.3284
Publikováno v:
Chemical and Pharmaceutical Bulletin. 28:1022-1034
9-Amino-1-(m-hydroxyphenyl) bicyclo [3. 3. 1] nonanes (Va) and their seven-membered homologs (Vb) were synthesized as potential analgetic agents. Condensation of acryloyl chloride with the morpholine enamine of the cyclohexanone (1a) gave the diketon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acffde41b8d9bd4a5bdc2b9f73252706
https://doi.org/10.1248/cpb.28.1022
https://doi.org/10.1248/cpb.28.1022
Publikováno v:
Science. 198:842-845
The unnatural (+) enantiomer of morphine had minimal activity in three opiate assays in vitro: the rat brain homogenate binding assay, the electrically stimulated guinea pig ileum assay, and the inhibition of adenylate cyclase in neuroblastoma X glio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57c417c92ee9536df9be80706ce0aef
https://doi.org/10.1126/science.199942
https://doi.org/10.1126/science.199942
Autor:
Norio Takamura, Yutaka Saiga, Tokuro Oh-Ishi, Akihiko Ishida, Yuzo Matsuoka, Toshikazu Miyagishima, Mamoru Matsumoto, Ikuo Iijima
Publikováno v:
Chemical and Pharmaceutical Bulletin. 35:3705-3712
Two tetrahydro-β-carboline-1-and-4-carboxylic acids (1b, c) and the corresponding hydroxymethyl derivatives (2b, c), which are positional isomers of the 3-carboxylic acid (1a) and its 3-hydroxymethyl derivative (2a), were synthesized and tested for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bb7b211d8e25011f16297872da9a95
https://doi.org/10.1248/cpb.35.3705
https://doi.org/10.1248/cpb.35.3705
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :3190-3195
2-[3-(1-Oxo-3-aminobut-2-enyl)-7-methoxy-5-methyl-4-oxo-4H-benzopyran-2-ylmethyl]dioxolans, (7a and b), with an ethoxycarbonylmethyl or methyl substituent on the 2-position, have been synthesised starting with three precursors corresponding to β-tet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e99ee181a334b694cdae04fe52504610
https://doi.org/10.1039/p19790003190
https://doi.org/10.1039/p19790003190
Publikováno v:
Journal of Heterocyclic Chemistry. 9:1355-1358
This paper describes the syntheses and the properties of 1H-pyrrolo[2,3-6]quinolines derived from 2,3-dihydrofuro[3,2-c]quinolines or 3-(β-chloroethyl)-2,4-dichloroquinolines. The discrepancy on the physical data of 1H-pyrrolo[2,3-b]quinoline betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30c5a0d5ace52b42ec915222c1348977
https://doi.org/10.1002/jhet.5570090628
https://doi.org/10.1002/jhet.5570090628