Zobrazeno 1 - 10
of 446
pro vyhledávání: '"Ikuo Hirano"'
Autor:
Daishi Ishihara, Atsushi Hasegawa, Ikuo Hirano, James Douglas Engel, Masayuki Yamamoto, Ritsuko Shimizu
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-5 (2024)
Abstract Transcription factor GATA1 controls the delicate balance between proliferation, differentiation and apoptosis in both the erythroid and megakaryocytic lineages. In addition to full-length GATA1, there is an GATA1 isoform, GATA1s, that lacks
Externí odkaz:
https://doaj.org/article/0da7065f10014576957b099afcbee69c
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-5 (2024)
Abstract GATA1 plays a critical role in differentiation, proliferation, and apoptosis during erythropoiesis. We developed a Gata1 knock-down allele (Gata1.05) that results in GATA1 expression at 5% of endogenous level. In female mice heterozygous for
Externí odkaz:
https://doaj.org/article/8a38ad00d0c8452391411aa2d69f0211
Autor:
Ritsuko Shimizu, Ikuo Hirano, Atsushi Hasegawa, Mikiko Suzuki, Akihito Otsuki, Keiko Taguchi, Fumiki Katsuoka, Akira Uruno, Norio Suzuki, Akane Yumoto, Risa Okada, Masaki Shirakawa, Dai Shiba, Satoru Takahashi, Takafumi Suzuki, Masayuki Yamamoto
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Spaceflight-related stresses impact health via various body systems, including the haematopoietic and immune systems, with effects ranging from moderate alterations of homoeostasis to serious illness. Oxidative stress appears to be involved
Externí odkaz:
https://doaj.org/article/cbdd5e395ae54f96aef12db4171df02b
Autor:
Atsushi Hasegawa, Yuki Hayasaka, Masanobu Morita, Yuta Takenaka, Yuna Hosaka, Ikuo Hirano, Masayuki Yamamoto, Ritsuko Shimizu
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
DCML deficiency is a disorder marked by loss of multiple immune cell types. Mutations that affect a single allele of the GATA2 transcription factor may lead to DCML by interfering with normal GATA2 binding, altering expression of important immune cel
Externí odkaz:
https://doaj.org/article/c939c3f08d06435b81aafa5fb4662229
Autor:
Ikuo Hirano, Norio Suzuki
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
While the neural crest is considered the fourth germ layer that originates a variety of tissues during mammalian development, we recently discovered that some neural crest cells and neuroepithelial cells play a unique role in secreting a vital hemato
Externí odkaz:
https://doaj.org/article/a3f10b73c7c54fe6ad8b16436b47e15e
Autor:
J Kirk Harris, Rui Fang, Brandie D Wagner, Ha Na Choe, Caleb J Kelly, Shauna Schroeder, Wendy Moore, Mark J Stevens, Alyson Yeckes, Katie Amsden, Amir F Kagalwalla, Angelika Zalewski, Ikuo Hirano, Nirmala Gonsalves, Lauren N Henry, Joanne C Masterson, Charles E Robertson, Donald Y Leung, Norman R Pace, Steven J Ackerman, Glenn T Furuta, Sophie A Fillon
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128346 (2015)
The microbiome has been implicated in the pathogenesis of a number of allergic and inflammatory diseases. The mucosa affected by eosinophilic esophagitis (EoE) is composed of a stratified squamous epithelia and contains intraepithelial eosinophils. T
Externí odkaz:
https://doaj.org/article/eaa5782acab94602bc11f3f4e1ca1a67
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25839 (2011)
Understanding the nature of renal erythropoietin-producing cells (REPs) remains a central challenge for elucidating the mechanisms involved in hypoxia and/or anemia-induced erythropoietin (Epo) production in adult mammals. Previous studies have shown
Externí odkaz:
https://doaj.org/article/dd0638f204b04d41a53dc0c018f2cfda
Autor:
Ikuo Hirano1 i-hirano@northwestern.edu, Dellon, Evan S.2, Gupta, Sandeep K.3,4, Katzka, David A.5, Collins, Margaret H.6, Wojtowicz, Abigail M.7, Terreri, Brian7, Zhang, Wenwen8, Boules, Mena7, Bhatia, Siddharth9, Desai, Nirav K.8
Publikováno v:
Alimentary Pharmacology & Therapeutics. May2023, Vol. 57 Issue 10, p1117-1130. 14p. 3 Charts, 2 Graphs.
Autor:
Bredenoord, Albert J., Dellon, Evan S., Ikuo Hirano, Lucendo, Alfredo J., Schlag, Christoph, Xian Sun, Glotfelty, Lila, Mannent, Leda, Maloney, Jennifer, Laws, Elizabeth, Mortensen, Eric, Shabbir, Arsalan
Publikováno v:
Gut; Mar2024, Vol. 73 Issue 3, p398-406, 9p
Autor:
Kara L Kliewer, Nirmala Gonsalves, Evan S Dellon, David A Katzka, Juan P Abonia, Seema S Aceves, Nicoleta C Arva, John A Besse, Peter A Bonis, Julie M Caldwell, Kelley E Capocelli, Mirna Chehade, Antonella Cianferoni, Margaret H Collins, Gary W Falk, Sandeep K Gupta, Ikuo Hirano, Jeffrey P Krischer, John Leung, Lisa J Martin, Paul Menard-Katcher, Vincent A Mukkada, Kathryn A Peterson, Tetsuo Shoda, Amanda K Rudman Spergel, Jonathan M Spergel, Guang-Yu Yang, Xue Zhang, Glenn T Furuta, Marc E Rothenberg
Publikováno v:
The Lancet Gastroenterology & Hepatology. 8:408-421
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16a0e37e68b2577e0e84526676d30a7f
https://doi.org/10.1016/s2468-1253(23)00012-2
https://doi.org/10.1016/s2468-1253(23)00012-2