Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Ikumi Hyoudoh"'
Autor:
Yasuhiko Shiratori, Hirosato Ebiike, Takaaki A. Fukami, Masahiro Sakaitani, Toshiyuki Tsukaguchi, Yuko Aoki, Nobuya Ishii, Kohsuke Asoh, Kenichi Kawasaki, Tatsuo Ohtsuka, Miyako Masubuchi, Nobuo Shimma, Osamu Kondoh, Ikumi Hyoudoh, Masami Kohchi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1753-1757
A series of benzofuran-based farnesyltransferase inhibitors have been designed and synthesized as antitumor agents. Among them, 11f showed the most potent enzyme inhibitory activity (IC 50 = 1.1 nM) and antitumor activity in human cancer xenografts i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05fa59cee8e2a785c9bbfd09094f894f
https://doi.org/10.1016/j.bmcl.2009.01.074
https://doi.org/10.1016/j.bmcl.2009.01.074
Autor:
Masayuki Matsushita, Kenji Takanashi, Hitoshi Iikura, Yasushi Tomii, Toshihiro Aoki, Noriyuki Furuichi, Yuko Aoki, Fumio Watanabe, Sawako Ozawa, Masahiro Sakaidani, Nobuo Shimma, Naoki Harada, Ikumi Hyoudoh
Publikováno v:
Cancer Research. 71:2789-2789
Background: Among tumor signaling pathways, the most frequently dysregulated in human cancer is Ras-Raf-MEK axis, and therefore allosteric MEK inhibitors and ATP competitive Raf inhibitors are being tested in clinical trials. However, these inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::025edc7633ff5b1612a9b7cb5ff64590
https://doi.org/10.1158/1538-7445.am2011-2789
https://doi.org/10.1158/1538-7445.am2011-2789