Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ikuko Ohtani"'
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1449-1456
A new approach for the synthesis of amino sugars using an allyl cyanate-to-isocyanate rearrangement has been developed. The key feature in this method involves introduction of the nitrogen substituent into the pyranose framework by [3,3] sigmatropic
Publikováno v:
European Journal of Pharmacology. 310:95-98
Ptilomycalin A inhibited the brain Na+, K(+)-ATPase and Ca2(+)-ATPase from skeletal sarcoplasmic reticulum with an IC50 value of 2 microM and 10 microM, respectively. Kinetic analysis of the inhibitory effects of ptilomycalin A suggests that the inhi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:3-8
Tautomycin, a well-known protein phosphatase inhibitor, exists in two forms (acid anhydride and diacid). We successfully isolated them and proved that diacid is the real active form of tautomycin. The molecular shape-activity relationship of tautomyc
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 60:1260-1264
Protein phosphatases are classified into types 1 (PP1) and 2 (PP2A, 2B, and 2C). We have already established a new analysis method for PP2A inhibitors by using the firefly bioluminescence system for detection. This method was successfully applied to
Autor:
Minoru Isobe, Yoshiaki Toya, Ikuko Ohtani, Yukiteru Sugiyama, Takeharu Ito, Akira Takai, Yoshiko Nishigohri
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 59:2235-2238
A new analysis method for protein phosphatase type 2A inhibitors was established that uses the firefly bioluminescence system for detection. Thus, firefly luciferin phosphate was used as a substrate, and the liberated free luciferin was determined fr
Autor:
Richard E. Moore, Lisa Demchik, Frederick A. Valeriote, Thomas H. Corbett, Golakoti Trimurtulu, Gregory M. L. Patterson, Ikuko Ohtani
Publikováno v:
Journal of the American Chemical Society. 116:4729-4737
Publikováno v:
ChemInform. 22
Publikováno v:
ChemInform. 23
Application of the modified Mosher's method to the N -MTPA derivatives of several amino acid esters and acyclic amines indicates that this method may be generally used to determine the absolute configurations of the α-carbons of amino compounds of l
Publikováno v:
ChemInform. 24
Publikováno v:
ChemInform. 26
The structure and stereochemistry of cereulide 1 or 1a, an emetic toxin produced by Bacillus cereus, have been determined through spectral analysis and chemical methods. It is a 36-membered cyclic depsipeptide with the sequence of cyclo(D-O-Leu-D-Ala