Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ikuko Nagasawa"'
Publikováno v:
iScience, Vol 23, Iss 4, Pp - (2020)
Summary: BRAF V600 mutation influences cellular signaling pathways for melanoma development. However, the role of oncogenic BRAF in adaptive stress response pathways is not fully understood. Here, we show that oncogenic BRAF plays an essential role i
Externí odkaz:
https://doaj.org/article/b2e7bdf248a94aadaac993b30e6909a6
Autor:
Ayaka Harada, Mizuki Takahashi, Yu Kato, Yoshikazu Sugimoto, Akihiro Tomida, Ikuko Nagasawa, Kazuhiro Kunimasa, Masanori Osawa
Publikováno v:
Molecular Pharmacology. 98:669-676
Eukaryotic initiation factor 2α (eIF2α) kinase general control nonderepressible 2 (GCN2) drives cellular adaptation to amino acid limitation by activating the integrated stress response that induces activating transcription factor 4 (ATF4). Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0708d2261158005113c03585c7fe7e
https://doi.org/10.1124/molpharm.120.000070
https://doi.org/10.1124/molpharm.120.000070
Publikováno v:
iScience, Vol 23, Iss 4, Pp-(2020)
iScience
iScience
Summary BRAF V600 mutation influences cellular signaling pathways for melanoma development. However, the role of oncogenic BRAF in adaptive stress response pathways is not fully understood. Here, we show that oncogenic BRAF plays an essential role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba10f76ac58b75ebc5eb1fbdf491e4ac
https://doi.org/10.1016/j.isci.2020.101028
https://doi.org/10.1016/j.isci.2020.101028
Autor:
Hiroyuki Osada, Makoto Kawatani, Tomokazu Ohishi, Ikuko Nagasawa, Shun-ichi Ohba, Makoto Muroi, Manabu Kawada
Publikováno v:
Cell Chemical Biology. 27:186-196.e4
Summary The cellular thermal shift assay (CETSA) has recently been devised as a label-free method for target validation of small compounds and monitoring the thermal stabilization or destabilization of proteins due to binding with the compound. Herei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd62c80d21f5aae12cc1670b25937f3
https://doi.org/10.1016/j.chembiol.2019.11.010
https://doi.org/10.1016/j.chembiol.2019.11.010
Autor:
Ikuko Nagasawa, Kiyotaka Koyama, Motto Shiro, Toshihiro Suzuki, Kaoru Kinoshita, Kazuto Nishio, Akira Kaneko
Publikováno v:
Journal of Natural Products. 77:963-968
One novel p-terphenyl compound, polyozellic acid (1), and its acetone adduct (3), along with a known p-terphenyl compound, thelephoric acid (2), were isolated from the mushroom Polyozellus multiplex. Their molecular structures were determined by spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb794bd79d8c78dfb2b0ee16804deb3c
https://doi.org/10.1021/np401046z
https://doi.org/10.1021/np401046z
Publikováno v:
Biochemical and biophysical research communications. 482(4)
In BRAF-mutated melanoma cells, the BRAF inhibitor, vemurafenib, induces phosphorylation of eukaryotic initiation factor 2α (eIF2α) and subsequent induction of activating transcription factor 4 (ATF4), the central regulation node of the integrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4987636d46aac1ba5ebb3fd6353697
https://pubmed.ncbi.nlm.nih.gov/27965097
https://pubmed.ncbi.nlm.nih.gov/27965097
Publikováno v:
Dental Medicine Research. 28:13-18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3772615b2eb4d2e6060b6dc574dc49f
https://doi.org/10.7881/dentalmedres2008.28.13
https://doi.org/10.7881/dentalmedres2008.28.13
Autor:
Kiyotaka Koyama, Ikuko Nagasawa, Kaoru Kinoshita, Toshihiro Suzuki, Kunio Takahashi, Miyuki Fukai
Publikováno v:
Journal of natural products. 77(4)
Hypoxylonol C (1), isolated from the inedible mushroom Hypoxylon truncatum, exhibited inhibitory activities against the migration and tube formation of HUVECs. A cDNA microarray analysis was performed to investigate the target of hypoxylonol C (1) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd33ac8fe0caff2b997e6a6d8d3db81a
https://pubmed.ncbi.nlm.nih.gov/24593182
https://pubmed.ncbi.nlm.nih.gov/24593182
Autor:
Yuki Ogasawara, Toshimitsu Yamaoka, Kazuto Nishio, Kiyotaka Koyama, Toshihiro Suzuki, Tohru Ohmori, Ikuko Nagasawa
Publikováno v:
Cancer Research. 76:1893-1893
Lung cancer is the leading cause of cancer related death in the world. Platinum-based combination regimen or molecular target drugs, such as EGFR tyrosine kinase inhibitors (EGFR-TKIs) and ALK inhibitors are used for first line chemotherapy of NSCLC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0d04180c55dab2ed79df3638e6c0aa7
https://doi.org/10.1158/1538-7445.am2016-1893
https://doi.org/10.1158/1538-7445.am2016-1893
Publikováno v:
Cancer Research. 76:4658-4658
The eIF2α-ATF4 signaling pathway termed “Integrated stress response (ISR)” plays an important role in protecting cells against various cellular stresses such as deprivation of glucose and amino acids, virus infection, and deficiency of heme. Und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ada9ffbd75f65a2dfc355103b02b6649
https://doi.org/10.1158/1538-7445.am2016-4658
https://doi.org/10.1158/1538-7445.am2016-4658