Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Ikuko Kozone"'
Autor:
Kei Kudo, Takehiro Nishimura, Ikuko Kozone, Junko Hashimoto, Noritaka Kagaya, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-ya
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Engineering polyketide synthases is one of the most promising ways of producing a variety of polyketide derivatives. Exploring the undiscovered chemical space of this medicinally important class of middle molecular weight natural products wi
Externí odkaz:
https://doaj.org/article/b2430429dc1949ffa90e4ad9492f1d0d
Autor:
Kei Kudo, Takuya Hashimoto, Junko Hashimoto, Ikuko Kozone, Noritaka Kagaya, Reiko Ueoka, Takehiro Nishimura, Mamoru Komatsu, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-ya
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Several different genetic strategies have been reported for the modification of polyketide synthases but the highly repetitive modular structure makes this difficult. Here the authors report on an adapted Cas9 reaction and Gibson assembly to edit a t
Externí odkaz:
https://doaj.org/article/6d001e0fbfd74c5b9143e6e06438d202
Autor:
Takayoshi Awakawa, Takuma Fujioka, Lihan Zhang, Shotaro Hoshino, Zhijuan Hu, Junko Hashimoto, Ikuko Kozone, Haruo Ikeda, Kazuo Shin-Ya, Wen Liu, Ikuro Abe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Modifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity. Here the authors use evolutionary alignments of NRPS/PKS gene clusters to guide ra
Externí odkaz:
https://doaj.org/article/209bc4d1b5344a32b292f405caa6ac8b
Autor:
Keita Amagai, Haruo Ikeda, Junko Hashimoto, Ikuko Kozone, Miho Izumikawa, Fumitaka Kudo, Tadashi Eguchi, Takemichi Nakamura, Hiroyuki Osada, Shunji Takahashi, Kazuo Shin-ya
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Telomestatin, a strong telomerase inhibitor with G-quadruplex stabilizing activity, is a potential therapeutic agent for treating cancers. Difficulties in isolating telomestatin from microbial cultures and in chemical synthesis are bottlenec
Externí odkaz:
https://doaj.org/article/bc74afa0add84c29833f93ffbe2a2b0d
Autor:
Chitose Maruyama, Yukiko Chinone, Shusuke Sato, Fumitaka Kudo, Kosuke Ohsawa, Junya Kubota, Junko Hashimoto, Ikuko Kozone, Takayuki Doi, Kazuo Shin-ya, Tadashi Eguchi, Yoshimitsu Hamano
Publikováno v:
Biomolecules, Vol 10, Iss 5, p 775 (2020)
Many pharmacologically important peptides are bacterial or fungal in origin and contain nonproteinogenic amino acid (NPA) building blocks. Recently, it was reported that, in bacteria, a cyclopropane-containing NPA 1-aminocyclopropanecarboxylic acid (
Externí odkaz:
https://doaj.org/article/526343c29b044f1396e2b1ae34af0915
Autor:
Myco Umemura, Hideaki Koike, Nozomi Nagano, Tomoko Ishii, Jin Kawano, Noriko Yamane, Ikuko Kozone, Katsuhisa Horimoto, Kazuo Shin-ya, Kiyoshi Asai, Jiujiang Yu, Joan W Bennett, Masayuki Machida
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84028 (2013)
Many bioactive natural products are produced as "secondary metabolites" by plants, bacteria, and fungi. During the middle of the 20th century, several secondary metabolites from fungi revolutionized the pharmaceutical industry, for example, penicilli
Externí odkaz:
https://doaj.org/article/9e08be6951244d86b9b07cbead749857
Autor:
Fumitaka Kudo, Atsushi Minato, Shusuke Sato, Nayuta Nagano, Chitose Maruyama, Yoshimitsu Hamano, Junko Hashimoto, Ikuko Kozone, Kazuo Shin-ya, Tadashi Eguchi
Publikováno v:
Organic Letters. 24:8975-8979
Autor:
Fumitaka, Kudo, Atsushi, Minato, Shusuke, Sato, Nayuta, Nagano, Chitose, Maruyama, Yoshimitsu, Hamano, Junko, Hashimoto, Ikuko, Kozone, Kazuo, Shin-Ya, Tadashi, Eguchi
Publikováno v:
Organic letters. 24(49)
The radical
Autor:
Akifumi Okuda, Eri Ena, Kazuo Shin-ya, Manabu Fujie, Yoshie Nishitsuji, Noriyuki Satoh, Ikuko Kozone, Junko Hashimoto, Haruo Ikeda, Shinya Okubo
Publikováno v:
Applied Microbiology and Biotechnology. 105:4177-4187
Bioconversion using microorganisms and their enzymes is an important tool in many industrial fields. The discovery of useful new microbial enzymes contributes to the development of industries utilizing bioprocesses. Streptomyces sp. EAS-AB2608, isola
Autor:
Takuya Hashimoto, Haruo Ikeda, Noritaka Kagaya, Kei Kudo, Reiko Ueoka, Hikaru Suenaga, Kazuo Shin-ya, Ikuko Kozone, Junko Hashimoto
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 85:890-894
A novel methymycin analog, 12-ketomethymycin N-oxide, was produced by the heterologous expression of the pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900 together with 12-ketomethymycin, which was only isolated by the biotra