Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Ikuko, Mizuta"'
Autor:
Toshiki Mizuno, Tomoyuki Ohara, Ikuko Mizuta, Akiko Watanabe-Hosomi, Hiraku Matsuura, Daiki Fukunaga, Akari Naito, Mitsuko Nakata, Aoi Uno, Yayoi Iwami, Toshiko Ito-Ihara, Satoshi Teramukai
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100350- (2024)
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebral small vessel disease caused by mutations in NOTCH3. CADASIL patients experienced recurrent strokes in middle age, resulting
Externí odkaz:
https://doaj.org/article/d19d915b59434b3f8b516e1de236fb5c
Progress to Clarify How NOTCH3 Mutations Lead to CADASIL, a Hereditary Cerebral Small Vessel Disease
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 127 (2024)
Notch signaling is conserved in C. elegans, Drosophila, and mammals. Among the four NOTCH genes in humans, NOTCH1, NOTCH2, and NOTCH3 are known to cause monogenic hereditary disorders. Most NOTCH-related disorders are congenital and caused by a gain
Externí odkaz:
https://doaj.org/article/61373c558c2c48a4ad9bdc0e5279f166
Autor:
Satoshi Saito, Satoshi Hosoki, Eriko Yamaguchi, Hiroyuki Ishiyama, Soichiro Abe, Takeshi Yoshimoto, Tomotaka Tanaka, Yi Chu Liao, Yi-Chung Lee, Ikuko Mizuta, Toshiki Mizuno, Masafumi Ihara
Publikováno v:
Neurology: Genetics; Oct2024, Vol. 10 Issue 5, p1-4, 4p
Autor:
Mao Mukai, Ai Hamano, Ikuko Mizuta, Isao Yokota, Akiko Watanabe-Hosomi, Hiraku Matsuura, Takashi Koizumi, Jun Matsuura, Tomoyuki Ohara, Shigenori Matsushima, Satoshi Teramukai, Kei Yamada, Toshiki Mizuno
Publikováno v:
Frontiers in Neurology, Vol 13 (2023)
BackgroundImpaired cerebrovasoreactivity is thought to play an important role in the pathophysiology of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). We aimed to clarify the association between
Externí odkaz:
https://doaj.org/article/8d5c042e35784a6a86b53058552e7ae3
Autor:
Akira Taniguchi, Akihiro Shindo, Ken-ichi Tabei, Osamu Onodera, Yukio Ando, Takao Urabe, Kazumi Kimura, Kazuo Kitagawa, Yoshihiro Miyamoto, Misa Takegami, Masafumi Ihara, Ikuko Mizuta, Toshiki Mizuno, Hidekazu Tomimoto
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
ObjectivesPatients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) show various clinical symptoms, including migraine, recurrent stroke, and cognitive impairment. We investigated the associati
Externí odkaz:
https://doaj.org/article/cd52335b25a34f74af81b82a76dc43d9
Autor:
Takashi Koizumi, Katsutoshi Taguchi, Ikuko Mizuta, Hiroe Toba, Makoto Ohigashi, Okihiro Onishi, Kazuya Ikoma, Seiji Miyata, Tetsuo Nakata, Masaki Tanaka, Sébastien Foulquier, Harry W. M. Steinbusch, Toshiki Mizuno
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-13 (2019)
Abstract Background Microglia play crucial roles in the maintenance of brain homeostasis. Activated microglia show a biphasic influence, promoting beneficial repair and causing harmful damage via M2 and M1 microglia, respectively. It is well-known th
Externí odkaz:
https://doaj.org/article/2ac3ba0aeded49a8a1a8a69f325d216d
Autor:
Fukiko Kitani-Morii, Yu-ichi Noto, Yukiko Tsuji, Kensuke Shiga, Ikuko Mizuta, Masanori Nakagawa, Toshiki Mizuno
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Introduction: We aimed to clarify when adult patients with Charcot-Marie-Tooth disease type 1A (CMT1A), especially those diagnosed at middle or advanced ages, first showed symptoms and whether the rate of disease progression is accelerated by aging.M
Externí odkaz:
https://doaj.org/article/f4aa54a1d67b413ba1eebf1fed977162
Autor:
Masahiro Uemura, Hiroaki Nozaki, Taisuke Kato, Akihide Koyama, Naoko Sakai, Shoichiro Ando, Masato Kanazawa, Nozomi Hishikawa, Yoshinori Nishimoto, Kiran Polavarapu, Atchayaram Nalini, Akira Hanazono, Daisuke Kuzume, Akihiro Shindo, Mohammad El-Ghanem, Arata Abe, Aki Sato, Mari Yoshida, Takeshi Ikeuchi, Ikuko Mizuta, Toshiki Mizuno, Osamu Onodera
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is clinically characterized by early-onset dementia, stroke, spondylosis deformans, and alopecia. In CARASIL cases, brain magnetic resonance imaging
Externí odkaz:
https://doaj.org/article/4020ff76709945468d33c1c5712ffc36
Autor:
Akihiro Shindo, Ken-ichi Tabei, Akira Taniguchi, Hiroaki Nozaki, Osamu Onodera, Akihiko Ueda, Yukio Ando, Takao Urabe, Kazumi Kimura, Kazuo Kitagawa, Haruo Hanyu, Teruyuki Hirano, Hideaki Wakita, Hidenao Fukuyama, Tatsuo Kagimura, Yoshihiro Miyamoto, Misa Takegami, Satoshi Saito, Akiko Watanabe-Hosomi, Ikuko Mizuta, Masafumi Ihara, Toshiki Mizuno, Hidekazu Tomimoto
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
ObjectivesClinical characteristics of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) include migraine, recurrent stroke, white matter lesions, and vascular dementia. CADASIL is one of the most com
Externí odkaz:
https://doaj.org/article/a1f8c4a059694bcd83ac5ce930a8e510
Autor:
Takashi Okada, Kazuo Washida, Kenichi Irie, Satoshi Saito, Michio Noguchi, Tsutomu Tomita, Masatoshi Koga, Kazunori Toyoda, Shuhei Okazaki, Takashi Koizumi, Ikuko Mizuta, Toshiki Mizuno, Masafumi Ihara
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Objectives: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary small vessel disease, with reported frequencies of 2-5/100,000 individuals. Recently, it has been reported
Externí odkaz:
https://doaj.org/article/b048d0036cc44c1aad29dd14abfc0e82