Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion

Autor: Alice Capuz, Sylvain Osien, Mélodie Anne Karnoub, Soulaimane Aboulouard, Estelle Laurent, Etienne Coyaud, Antonella Raffo-Romero, Marie Duhamel, Amélie Bonnefond, Mehdi Derhourhi, Marco Trerotola, Ikram El Yazidi-Belkoura, David Devos, Monika Zilkova, Firas Kobeissy, Fabien Vanden Abeele, Isabelle Fournier, Dasa Cizkova, Franck Rodet, Michel Salzet

Publikováno v: Cell Death and Disease, Vol 14, Iss 4, Pp 1-16 (2023)

Abstract Using multi-omics analyses including RNAseq, RT-PCR, RACE-PCR, and shotgun proteomic with enrichment strategies, we demonstrated that newborn rat astrocytes produce neural immunoglobulin constant and variable heavy chains as well as light ch

Externí odkaz: https://doaj.org/article/4a879d4e7d604bcc8c22d0f2991b82bb

Targeting O-GlcNAcylation to overcome resistance to anti-cancer therapies

Autor: Ninon Very, Ikram El Yazidi-Belkoura

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

In cancer cells, metabolic reprogramming is associated with an alteration of the O-GlcNAcylation homeostasis. This post-translational modification (PTM) that attaches O-GlcNAc moiety to intracellular proteins is dynamically and finely regulated by th

Externí odkaz: https://doaj.org/article/9797206a006c40609e7b045ee22ca267

Front Cover: Control of lipid metabolism by the dynamic and nutrient‐dependent post‐translational modification O ‐GlcNAcylation

Autor: Céline Schulz, Quentin Lemaire, Alexandre Berthier, Amandine Descat, Mostafa Kouach, Anne‐Sophie Vercoutter‐Edouart, Ikram El Yazidi‐Belkoura, Stéphan Hardivillé, Jean‐François Goossens, Philippe Lefebvre, Tony Lefebvre

Publikováno v: Natural Sciences. 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4a182e7d75661568012c589d97c1c07
https://doi.org/10.1002/ntls.202320001

Dual regulation of fatty acid synthase (FASN) expression by O-GlcNAc transferase (OGT) and mTOR pathway in proliferating liver cancer cells

Autor: Alexis Gadault, Anne-Sophie Vercoutter-Edouart, Ninon Very, Amélie Decourcelle, Tony Lefebvre, Ganna Panasyuk, Ikram El Yazidi-Belkoura, Stéphan Hardivillé, Céline Schulz, Marlène Mortuaire, Quentin Lemaire, Sadia Raab, Steffi Baldini, Vanessa Dehennaut

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2021, Cellular and Molecular Life Sciences, 78 (10), ⟨10.1007/s00018-021-03857-z⟩
Cellular and Molecular Life Sciences, 2021, Cellular and Molecular Life Sciences, 78 (10), ⟨10.1007/s00018-021-03857-z⟩

International audience; Fatty acid synthase (FASN) participates in many fundamental biological processes, including energy storage and signal transduction, and is overexpressed in many cancer cells. We previously showed in a context of lipogenesis th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2046a0425144f2036c092541a8e856ea
https://doi.org/10.1007/s00018-021-03857-z

Evaluation of the expression of fatty acid synthase and O‑GlcNAc transferase in patients with liver cancer by exploration of transcriptome databases and experimental approaches

Autor: Sadia Raab, Ninon Very, Belinda Duchêne, Pierre Rybarczyk, Nicolas Jonckheere, Ikram El Yazidi‑belkoura, Tony Lefebvre

Publikováno v: Oncology Letters
Oncology Letters, 2022, 23 (4), pp.105. ⟨10.3892/ol.2022.13225⟩

International audience; Tumor occurrence and development are closely related to metabolism abnormalities. One of the metabolic networks that is dysregulated during carcinogenesis is the fatty acid synthesis pathway, which is mainly controlled by fatt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14321294d63bfea1c667090e57a68d97
https://doi.org/10.3892/ol.2022.13225