Výsledky vyhledávání - "Iker Lopez Calderero"

Data from Spinophilin Loss Correlates with Poor Patient Prognosis in Advanced Stages of Colon Carcinoma

Autor: Amancio Carnero, Rocio Garcia-Carbonero, Luis Paz-Ares, Blanca Felipe-Abrio, Antonio Lucena-Cacace, Lourdes Gomez-Izquierdo, Ana Salinas, Sandra Muñoz-Galvan, Sonia Molina-Pinelo, Iker Lopez-Calderero, Purificacion Estevez-Garcia

Purpose: The genomic region 17q21 is frequently associated with microsatellite instability and LOH in cancer, including gastric and colorectal carcinomas. This region contains several putative tumor suppressor genes, including Brca1, NM23, prohibitin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9fefadd73b156218fc8927942ad860
https://doi.org/10.1158/1078-0432.c.6521171

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Prognostic relevance of Src activation in stage II-III colon cancer

Autor: Marta Benavent, Javier Salamanca, María Luisa Limón, Iker Lopez-Calderero, Reyes Gonzalez-Exposito, Rocio Garcia-Carbonero, Amancio Carnero, Beatriz Soldevilla, Carmen Sáez, Maria C Riesco-Martinez, Julia Martinez-Perez

Publikováno v: Human pathology. 67

Src belongs to a family of cytoplasmic tyrosine kinases that play a key role in tumor initiation and progression. Src activation has been associated with a more aggressive neoplastic phenotype and induces resistance to platinum agents in preclinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a873cd5fd971e1e23f4b30f65e51a9
https://pubmed.ncbi.nlm.nih.gov/28601656

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Prognostic relevance of estrogen receptor-alpha Ser167 phosphorylation in stage II-III colon cancer patients

Autor: María Luisa Limón, José Palacios, Marta Benavent, Rocio Garcia-Carbonero, Amancio Carnero, Manuel Chaves, Aurora Astudillo, Iker Lopez-Calderero

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Preclinical and clinical data suggest a protective role for estrogens on colon cancer (CRC) risk. estrogen receptor (ER) β is the prevalent ER in normal colonic mucosa, whereas its expression is significantly reduced in CRC. An increased ERα/β rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f1bd0123d76ecd33ee58098f682196
http://hdl.handle.net/10261/143130

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Spinophilin loss correlates with poor patient prognosis in advanced stages of colon carcinoma

Autor: Amancio Carnero, Lourdes Gomez-Izquierdo, Luis Paz-Ares, Ana Salinas, Blanca Felipe-Abrio, Sandra Muñoz-Galván, Antonio Lucena-Cacace, Iker Lopez-Calderero, Purificacion Estevez-Garcia, Rocio Garcia-Carbonero, Sonia Molina-Pinelo

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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[Purpose+ The genomic region 17q21 is frequently associated with microsatellite instability and LOH in cancer, including gastric and colorectal carcinomas. This region contains several putative tumor suppressor genes, including Brca1, NM23, prohibiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afaf5d63634683bc068b0f8de7024da7
http://hdl.handle.net/10261/143142

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PDGFR / and VEGFR2 polymorphisms in colorectal cancer: incidence and implications in clinical outcome

Autor: Rocio Garcia-Carbonero, Fernando Lopez-Rios, Amancio Carnero, Sonia Molina-Pinelo, Maria Dolores Pastor, Joaquín Iglesias, A Castaño, Iker Lopez-Calderero, Ana C. Martín, Sandra Muñoz-Galván, Purificacion Estevez-Garcia, Luis Paz-Ares

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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BMC Cancer, Vol 12, Iss 1, p 514 (2012)
BMC Cancer

Background Angiogenesis plays an essential role in tumor growth and metastasis, and is a major target in cancer therapy. VEGFR and PDGFR are key players involved in this process. The purpose of this study was to assess the incidence of genetic varian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92eb4f7eba62e1cbf2db0aa42dc1a6e4
http://hdl.handle.net/10261/63644

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The insulin-like growth factor pathway as a target for cancer therapy

Autor: Rocio Garcia-Carbonero, Iker Lopez-Calderero, Elizabeth Sánchez Chávez

Publikováno v: Clinicaltranslational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 12(5)

The insulin-like growth factor (IGF) system is emerging as a promising new target in cancer therapy. Experimental models and epidemiological studies have demonstrated that the IGF system plays a key role in malignant transformation and cancer progres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a175bcdfe4ab6783c48b1be051cb32
https://pubmed.ncbi.nlm.nih.gov/20466617

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Abstract 4644: PDGFRα/β and VEGFR2 SNPs incolorectal cancer

Autor: Fernando Lopez-Rios, Iker Lopez-Calderero, Sonia Molina-Pinelo, Rocio Garcia-Carbonero, Sandra Muñoz-Galván, Purificacion Estevez-Garcia, Ana C. Martín, Julio Iglesias, Luis Pa-Ares, Maria Dolores Pastor, Amancio Carnero, A Castaño

Publikováno v: Cancer Research. 73:4644-4644

Angiogenesis plays an essential role in tumor growth and metastasis, and is a major target in cancer therapy. VEGFR and PDGFR are key players involved in this process. The purpose of this study was to assess the incidence of genetic variants in these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5c92e657e2a06813d54c5548d70595e
https://doi.org/10.1158/1538-7445.am2013-4644

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