Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ikenna G Madu"'
Autor:
Ikenna G Madu, Megan Files, Dima N Gharaibeh, Amy L Moore, Kie-Hoon Jung, Brian B Gowen, Dongcheng Dai, Kevin F Jones, Shanthakumar R Tyavanagimatt, James R Burgeson, Marcus J Korth, Kristin M Bedard, Shawn P Iadonato, Sean M Amberg
Publikováno v:
PLoS Pathogens, Vol 14, Iss 12, p e1007439 (2018)
Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which there is no approved antiviral therapy. Lassa fever in particular generates high morbidity and mortality in West Africa, where the disease is endemic, and a r
Externí odkaz:
https://doaj.org/article/158943d5f7714c32981e426acdf08c68
Autor:
Kathleen A. Cashman, Eric R. Wilkinson, Jeffrey Posakony, Ikenna G. Madu, Eric J. Tarcha, Kurt H. Lustig, Marcus J. Korth, Kristin M. Bedard, Sean M. Amberg
Publikováno v:
Scientific reports. 12(1)
LHF-535 is a small molecule antiviral currently in development for the treatment of Lassa fever, a zoonotic disease endemic in West Africa that generates significant morbidity and mortality. Current treatment options are inadequate, and there are no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24374c75ec17e0a01884cf45598eb0a2
https://pubmed.ncbi.nlm.nih.gov/36402782
https://pubmed.ncbi.nlm.nih.gov/36402782
Autor:
James R. Burgeson, Kristin Bedard, Sean M. Amberg, Megan Files, Kevin F. Jones, Shawn P. Iadonato, Marcus J. Korth, Dima N. Gharaibeh, Dongcheng Dai, Amy L. Moore, Ikenna G. Madu, Shanthakumar R. Tyavanagimatt, Kieh-Hoon Jung, Brian B. Gowen
Publikováno v:
PLoS Pathogens, Vol 14, Iss 12, p e1007439 (2018)
PLoS Pathogens
Animal, Dairy, and Veterinary Science Faculty Publications
PLoS Pathogens
Animal, Dairy, and Veterinary Science Faculty Publications
Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which there is no approved antiviral therapy. Lassa fever in particular generates high morbidity and mortality in West Africa, where the disease is endemic, and a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfd2114900d28a5cf2d40cc650d80a8
https://doaj.org/article/158943d5f7714c32981e426acdf08c68
https://doaj.org/article/158943d5f7714c32981e426acdf08c68
Publikováno v:
ACS Chemical Biology. 8:1435-1441
Enzymes called SENPs catalyze both the maturation of small ubiquitin-like modifier (SUMO) precursors and removal of SUMO modifications, which regulate essential cellular functions such as cell cycle progression, DNA damage response and intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca02d75f76f8559849a964259126b05
https://doi.org/10.1021/cb400177q
https://doi.org/10.1021/cb400177q
Autor:
Shirley Xin Li, Jiing-Kuan Yee, John J. Rossi, Yuan Chen, John A. Zaia, Tammy T. Chang, Yi-Jia Li, Haitang Li, Ikenna G. Madu, Baozong Li, Ramir Vega
Publikováno v:
Scientific Reports
We have recently identified a chemotype of small ubiquitin-like modifier (SUMO)-specific protease (SENP) inhibitors. Prior to the discovery of their SENP inhibitory activity, these compounds were found to inhibit HIV replication, but with an unknown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0b768e2191ca98697b41223bdb50b2
https://doi.org/10.1038/srep17808
https://doi.org/10.1038/srep17808
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry
Journal of Biological Chemistry
Proteolytic priming is a common method of controlling the activation of membrane fusion mediated by viral glycoproteins. The severe acute respiratory syndrome coronavirus spike protein (SARS-CoV S) can be primed by a variety of host cell proteases, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2849db65caf44b3c29842a100578ca0
https://doi.org/10.1074/jbc.m110.103275
https://doi.org/10.1074/jbc.m110.103275
Publikováno v:
Virology
The S2 domain of the coronavirus spike (S) protein is known to be responsible for mediating membrane fusion. In addition to a well-recognized cleavage site at the S1–S2 boundary, a second proteolytic cleavage site has been identified in the severe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473bb156230c3ade8fa1dedbe2177bf9
Autor:
Ikenna G. Madu, Yuan Chen
Publikováno v:
Current Protocols in Molecular Biology
Post-translational modifications by the SUMO (Small Ubiquitin-like MOdifier) family of proteins are recently discovered essential regulatory mechanisms. All SUMO proteins are synthesized as larger precursors that are matured by SUMO-specific protease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7449b9ffe3e9dcc01b50e51878ee9901
https://pubmed.ncbi.nlm.nih.gov/22870856
https://pubmed.ncbi.nlm.nih.gov/22870856
Publikováno v:
Journal of Virology
Many viral fusion proteins are primed by proteolytic cleavage near their fusion peptides. While the coronavirus (CoV) spike (S) protein is known to be cleaved at the S1/S2 boundary, this cleavage site is not closely linked to a fusion peptide. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900936a90fd34f5e3f68814312b28118
https://pubmed.ncbi.nlm.nih.gov/19439480
https://pubmed.ncbi.nlm.nih.gov/19439480
Autor:
Gary R. Whittaker, Beverley E. Bauman, Hwajin Lee, Ikenna G. Madu, Andrew D. Regan, Victor C. Chu
Publikováno v:
Avian diseases. 51(1)
The avian coronavirus infectious bronchitis virus (IBV) strain Beaudette is an embryo-adapted virus that has extended species tropism in cell culture. In order to understand the acquired tropism of the Beaudette strain, we compared the S protein sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee5e0a754942d288ad2ddb7924c849f
https://pubmed.ncbi.nlm.nih.gov/17461266
https://pubmed.ncbi.nlm.nih.gov/17461266