Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ikei S. Kobayashi"'
Autor:
Motohiro Izumi, Masanori Fujii, Ikei S. Kobayashi, Vivian Ho, Yukie Kashima, Hibiki Udagawa, Daniel B. Costa, Susumu S. Kobayashi
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-11 (2024)
Abstract In EGFR-mutated lung cancer, the duration of response to tyrosine kinase inhibitors (TKIs) is limited by the development of acquired drug resistance. Despite the crucial role played by apoptosis-related genes in tumor cell survival, how thei
Externí odkaz:
https://doaj.org/article/0b4880c0b7b44dc7aa9de281cdad4388
Autor:
Ikei S. Kobayashi, MD, PhD, William Shaffer, MS, Hollis Viray, MD, Deepa Rangachari, MD, Paul A. VanderLaan, MD, PhD, Susumu S. Kobayashi, MD, PhD, Daniel B. Costa, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 1, Pp 100614- (2024)
Introduction: Mechanisms of resistance to EGFR exon 20 insertion mutation active inhibitors have not been extensively studied in either robust preclinical models or patient-derived rebiopsy specimens. We sought to characterize on-target resistance mu
Externí odkaz:
https://doaj.org/article/9d6f86ae7ca94cdea9028f4d32112c40
Autor:
Pedro E.N.S. Vasconcelos, MS, Ikei S. Kobayashi, MD, PhD, Susumu S. Kobayashi, MD, PhD, Daniel B. Costa, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 3, Pp 100105- (2021)
Introduction: EGFR exon 20 insertion mutations account for 10% of all EGFR mutations and are mostly insensitive to approved EGFR tyrosine kinase inhibitors (EGFR TKIs). Novel EGFR TKIs have been developed or repurposed for these mutants. A limited nu
Externí odkaz:
https://doaj.org/article/000298c3a25d4651aa115a4e30b75810
Autor:
Pedro E.N.S. Vasconcelos, MS, Carol Gergis, MS, Hollis Viray, MD, Andreas Varkaris, MD, PhD, Masanori Fujii, MD, PhD, Deepa Rangachari, MD, Paul A. VanderLaan, MD, PhD, Ikei S. Kobayashi, MD, PhD, Susumu S. Kobayashi, MD, PhD, Daniel B. Costa, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 1, Iss 3, Pp 100051- (2020)
Introduction: The EGFR-A763_Y764insFQEA is a unique exon 20 insertion mutation (∼5% to 6% of exon 20 insertions), which, at the structural and enzyme kinetic level, more closely resembles EGFR tyrosine kinase inhibitor (TKI)–sensitizing mutants,
Externí odkaz:
https://doaj.org/article/b0e73be55f654db78b7ddafa36ce97a9
Publikováno v:
Cells, Vol 10, Iss 12, p 3561 (2021)
Epidermal growth factor receptor (EGFR) exon 20 insertion mutations account for a tenth of all EGFR mutations in lung cancers. An important unmet clinical need is the identification of EGFR exon 20 insertion mutants that can respond to multiple class
Externí odkaz:
https://doaj.org/article/e65dd9a2c7cf4e4f9bca2f5cb2dd4e8f
Autor:
Simone Ummarino, Clinton Hausman, Giulia Gaggi, Lucrezia Rinaldi, Mahmoud A. Bassal, Yanzhou Zhang, Andy Joe Seelam, Ikei S. Kobayashi, Marta Borchiellini, Alexander K. Ebralidze, Barbara Ghinassi, Bon Q. Trinh, Susumu S. Kobayashi, Annalisa Di Ruscio
Publikováno v:
Cells, Vol 10, Iss 11, p 2986 (2021)
Nutritional intake impacts the human epigenome by directing epigenetic pathways in normal cell development via as yet unknown molecular mechanisms. Consequently, imbalance in the nutritional intake is able to dysregulate the epigenetic profile and dr
Externí odkaz:
https://doaj.org/article/95f6f216f4354e839427510a4d5e52e5
Autor:
Radhakrishnan Sridhar, Hisashi Takei, Riyaz Syed, Ikei S. Kobayashi, Liu Bee Hui, Ahmed Kamal, Daniel G. Tenen, Susumu S. Kobayashi
Publikováno v:
Molecules, Vol 23, Iss 8, p 1938 (2018)
The CCAAT enhancer-binding protein α (C/EBPα) plays an important role in myeloid cell differentiation and in the enhancement of C/EBPα expression/activity, which can lead to granulocytic differentiation in acute myeloid leukemia (AML) cells. We fo
Externí odkaz:
https://doaj.org/article/a0fb1e92d47743b49e685424c5ebe306
Autor:
Fareesa Aftab, Alice Rodriguez-Fuguet, Luis Silva, Ikei S. Kobayashi, Jiao Sun, Katerina Politi, Elena Levantini, Wei Zhang, Susumu S. Kobayashi, Wen Cai Zhang
Publikováno v:
British Journal of Cancer. 128:1647-1664
Background Lung cancer cells overexpress mucin 1 (MUC1) and active subunit MUC1-CT. Although a peptide blocks MUC1 signalling, metabolites targeting MUC1 are not well studied. AICAR is a purine biosynthesis intermediate. Methods Cell viability and ap
Autor:
Daisuke Shibahara, Naoki Akanuma, Ikei S. Kobayashi, Eunyoung Heo, Mariko Ando, Masanori Fujii, Feng Jiang, P. Nicholas Prin, Gilbert Pan, Kwok‐Kin Wong, Daniel B. Costa, Deepak Bararia, Daniel G. Tenen, Hideo Watanabe, Susumu S. Kobayashi
Publikováno v:
Cancer Science.
Autor:
Susumu S. Kobayashi, Yutaka Suzuki, Katsuya Tsuchihara, Koichi Goto, Masahide Seki, Akihiro Ohashi, Masanori Fujii, Kosuke Tanaka, Yuji Shibata, Hiroki Izumi, Hibiki Udagawa, David Plotnick, Ikei S. Kobayashi, Kyoko Muto, Ayako Suzuki, Daisuke Shibahara, Yukie Kashima
Supplemental Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c859d80b945fc738e4748387f96f4a
https://doi.org/10.1158/0008-5472.22428058
https://doi.org/10.1158/0008-5472.22428058