Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Ikechukwu I. Ekekezie"'
Autor:
Angels Navarro, Venkatesh Sampath, Michael F. Nyp, Heather Menden, Sherry M Mabry, Ricardo E. Perez, Ikechukwu I. Ekekezie
Publikováno v:
Physiological Reports
The onset and degree of injury occurring in animals that develop hyperoxic acute lung injury (HALI) is dependent on age at exposure, suggesting that developmentally regulated pathways/factors must underlie initiation of the epithelial injury and subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9081b4b24abf1dd98520204947d03fe7
http://europepmc.org/articles/PMC5827472
http://europepmc.org/articles/PMC5827472
Autor:
Angels Navarro, Sherry M Mabry, Ricardo E. Perez, Mohammad H. Rezaiekhaligh, Ikechukwu I. Ekekezie
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 300:L799-L807
Epithelial-mesenchymal transition (EMT) is a process by which epithelial cells undergo conversion to a mesenchymal phenotype contributing to wound repair by fibrosis and to cancer cell acquisition of invasive ability. Recently, we showed that type II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182c493f91bcc37c7beba6c874e1f9fd
https://doi.org/10.1152/ajplung.00350.2010
https://doi.org/10.1152/ajplung.00350.2010
Autor:
Mo Rezaiekhaligh, Sherry M Mabry, Stan Svojanovsky, Michael J. Soares, Dong Xu, Ikechukwu I. Ekekezie, William E Truog
Publikováno v:
Pediatric Research. 64:56-62
It is unclear how sublethal hypoxia affects lung development. To investigate the effects of chronic hypoxia on postnatal lung remodeling, we treated neonatal rats with FIO2 of 0.12 for 10 d and analyzed lung development by morphometry and gene expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4f5e76ec04e1ed965f36878bf6612a
https://doi.org/10.1203/pdr.0b013e31817289f2
https://doi.org/10.1203/pdr.0b013e31817289f2
Autor:
Sherry M Mabry, Carey A. Ehlert, Uttam Garg, William E. Truog, Donald W. Thibeault, Mike Norberg, Ikechukwu I. Ekekezie, Mo Rezaiekhaligh
Publikováno v:
Neonatology. 90:89-97
Background: Hyperoxia and tidal volume mechanical ventilation are independent factors in the genesis of lung injury, but it remains unclear the extent to which each is responsible or contributes to this process in newborns. Objectives: To study the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12dcd213a2c94db1ee18579f47a84f5d
https://doi.org/10.1159/000092005
https://doi.org/10.1159/000092005
Autor:
William E Truog, Donald W Thibeault, Mo Rezaiekhaligh, Sherry M Mabry, Xiaoming Zhang, Patrick Reinsvold, Shilpa Buch, Ikechukwu I. Ekekezie
Publikováno v:
Pediatric Research. 57:523-529
The peptides platelet-derived growth factor-A (PDGF-A) and especially -B have important roles in lung development. The effect of hyperoxic exposure with and without inhaled nitric oxide (iNO) on lung expression of PDGF and its receptors is unknown. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80ee67aae47dde11697ae09ecb68a17
https://doi.org/10.1203/01.pdr.0000155762.91748.8d
https://doi.org/10.1203/01.pdr.0000155762.91748.8d
Publikováno v:
American Journal of Perinatology. 22:11-17
In this retrospective study, we tested the following hypotheses: rates of severe intraventricular hemorrhage (SIVH) and early neonatal survival are similar among extremely low birth weight (ELBW) infants treated with combination prophylaxis of phenob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2b5a902d3c010cd067b9b86180a10e
https://doi.org/10.1055/s-2004-837741
https://doi.org/10.1055/s-2004-837741
Autor:
Michael Norberg, William E Truog, Philip L. Ballard, Roberta A. Ballard, Donald W Thibeault, Stephen D. Simon, Ikechukwu I. Ekekezie, Jeffrey D. Merrill
Publikováno v:
Pediatrics. 113:1709-1714
Objective. The pathogenesis of chronic lung disease (CLD) involves inflammation with proteolytic damage to lung extracellular matrix. Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that, acting in concert with their tissue inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e54c9a5e725d5240437ee5fd9562ca2
https://doi.org/10.1542/peds.113.6.1709
https://doi.org/10.1542/peds.113.6.1709
Autor:
Michael Norberg, William E. Truog, Ikechukwu I. Ekekezie, Sherry M Mabry, Donald W. Thibeault
Publikováno v:
Neonatology. 85:273-282
Microvascular development is critical for normal lung maturation. The aims of this study were (1) to quantitatively and qualitatively assess lung microvascular growth in the human fetus, from 22 to 40 weeks’ gestation, and (2) to compare developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e0fa53c61d52f2931342fbe395608e
https://doi.org/10.1159/000076388
https://doi.org/10.1159/000076388
Autor:
William E Truog, Mohammad H. Rezaiekhaligh, Donald W Thibeault, Michael Norberg, Ikechukwu I. Ekekezie, Sherry M Mabry, Xiaoming Zhang
Publikováno v:
Pediatric Research. 53:440-446
Pulmonary hyperoxic injury manifests as widespread alveolar-epithelial and microvascular endothelial cell necrosis, resolution of which requires angiogenesis. We investigated the hypothesis that inhaled nitric oxide (iNO) and hyperoxia each decreases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0231f735220afd951273b8bf99d69c7e
https://doi.org/10.1203/01.pdr.0000050121.70693.1a
https://doi.org/10.1203/01.pdr.0000050121.70693.1a
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2014 (2014)
BioMed Research International, Vol 2014 (2014)
Pulmonary lymphatic development in chronic lung disease (CLD) has not been investigated, and anatomy of lymphatics in human infant lungs is not well defined.Hypothesis. Pulmonary lymphatic hypoplasia is present in CLD.Method. Autopsy lung tissues of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c678c3ff085ff2e2375bc6db79900c7