Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ika Kristiana"'
Autor:
Winnie Luu, Eser J. Zerenturk, Ika Kristiana, Martin P. Bucknall, Laura J. Sharpe, Andrew J. Brown
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 3, Pp 410-420 (2014)
The role of signaling in regulating cholesterol homeostasis is gradually becoming more widely recognized. Here, we explored how kinases and phosphorylation sites regulate the activity of the enzyme involved in the final step of cholesterol synthesis,
Externí odkaz:
https://doaj.org/article/0bc11d238d6a4d2ead8669b0473e7254
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8496 (2009)
BACKGROUND:Recently, there has been renewed interest in the link between cholesterol and prostate cancer. It has been previously reported that in vitro, prostate cancer cells lack sterol-mediated feedback regulation of the major transcription factor
Externí odkaz:
https://doaj.org/article/2c06bffd4a9040fd808ccea183d166bb
Publikováno v:
Proceedings of the 2nd International Conference on Psychological Studies.
Autor:
Ika Kristiana, Laura J. Sharpe, Lisa Phan, Andrew J. Brown, Julian Stevenson, Noam Zelcer, Anke Loregger, Emma C. L. Cook
Publikováno v:
Molecular and cellular biology, 34(7), 1262-1270. American Society for Microbiology
The mevalonate pathway is used by cells to produce sterol and nonsterol metabolites and is subject to tight metabolic regulation. We recently reported that squalene monooxygenase (SM), an enzyme controlling a rate-limiting step in cholesterol biosynt
Autor:
Ika Kristiana, Winnie Luu, Laura J. Sharpe, Martin P. Bucknall, Andrew J. Brown, Eser J. Zerenturk
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 3, Pp 410-420 (2014)
The role of signaling in regulating cholesterol homeostasis is gradually becoming more widely recognized. Here, we explored how kinases and phosphorylation sites regulate the activity of the enzyme involved in the final step of cholesterol synthesis,
Autor:
Sian Cartland, Jitendra D. Belani, Wendy Jessup, Winnie Luu, Scott D. Rychnovsky, Andrew J. Brown, Ika Kristiana, Julian Stevenson
Publikováno v:
Journal of Biological Chemistry. 287:33897-33904
How cholesterol is sensed to maintain homeostasis has been explained by direct binding to a specific protein, Scap, or through altering the physical properties of the membrane. The enantiomer of cholesterol (ent-cholesterol) is a valuable tool in dis
Publikováno v:
The Pharmacogenomics Journal. 10:396-407
Antipsychotic drugs (APDs) have been reported to induce lipogenic genes. This has been proposed to contribute to their efficacy in treating schizophrenia and other psychiatric disorders, as well as the metabolic side effects often associated with the
Publikováno v:
The FASEB Journal. 29
Publikováno v:
Molecular Biology of the Cell. 17:2735-2745
Akt is a critical regulator of cell growth, proliferation, and survival that is activated by phosphatidylinositol 3-kinase (PI3K). We investigated the effect of PI3K inhibition on activation of sterol regulatory element binding protein-2 (SREBP-2), a
Publikováno v:
The Biochemical journal. 461(3)
SM (squalene mono-oxygenase) catalyses the first oxygenation step in cholesterol synthesis, immediately before the formation of the steroid backbone at lanosterol. SM is an important control point in the pathway, and is regulated at the post-translat