Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ik-Rak Jung"'
Autor:
Richa Tyagi, Suwarna Chakraborty, Sunil Jamuna Tripathi, Ik-Rak Jung, Sangwon F. Kim, Solomon H. Snyder, Bindu D. Paul
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107199- (2023)
Summary: Maintenance of redox balance plays central roles in a plethora of signaling processes. Although physiological levels of reactive oxygen and nitrogen species are crucial for functioning of certain signaling pathways, excessive production of f
Externí odkaz:
https://doaj.org/article/872d7538b9ac4ec9875a5b192c097dbe
Publikováno v:
Journal of Cellular Physiology. 237:3421-3432
Hepatic glucose production (HGP) is crucial for the maintenance of normal glucose homeostasis. Although hepatic insulin resistance contributes to excessive glucose production, its mechanism is not well understood. Here, we show that inositol polyphos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1242e27d19e4b5d154a32c64440299bc
https://doi.org/10.1002/jcp.30827
https://doi.org/10.1002/jcp.30827
Insulin resistance is a critical mediator of the development of non-alcoholic fatty liver disease (NAFLD). An excess influx of fatty acids to the liver is thought to be a pathogenic cause of insulin resistance and the development of non-alcoholic fat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8635eaa7a0c8423d6433b7459d7c648
https://doi.org/10.1101/2023.04.26.538310
https://doi.org/10.1101/2023.04.26.538310
Hepatic glucose production is crucial for the maintenance of normal glucose homeostasis. Although hepatic insulin resistance contributes to excessive glucose production, its mechanism is not well understood. Here, we show that inositol polyphosphate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfeb19cec14c6bbb99a3e21be39e8025
https://doi.org/10.1101/2022.03.10.483655
https://doi.org/10.1101/2022.03.10.483655
Autor:
Yup Kang, Jong-Gab Jung, Sung-E Choi, Hae Jin Kim, Seung Jin Han, Ik-Rak Jung, Kwan Woo Lee, Dae Jung Kim, Sang-A Lee
Publikováno v:
Molecular and Cellular Endocrinology. 407:74-84
High levels of plasma free fatty acid are thought to contribute to the loss of pancreatic beta-cells in type 2 diabetes. In particular, saturated fatty acid such as palmitate or stearate can induce apoptosis in cultured beta cells (lipotoxicity). End
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbea682f33bad57f9ced0812e5758e5
https://doi.org/10.1016/j.mce.2015.03.007
https://doi.org/10.1016/j.mce.2015.03.007
Publikováno v:
SCIENTIFIC REPORTS(7)
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Beta cell loss and insulin resistance play roles in the pathogenesis of type 2 diabetes. Elevated levels of free fatty acids in plasma might contribute to the loss of beta cells. The objective of this study was to find a chemical that could protect a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0cb8b20d1cc2c80468135efbc8edc1
http://open-repository.kisti.re.kr/cube/handle/open_repository/484960.do
http://open-repository.kisti.re.kr/cube/handle/open_repository/484960.do
Autor:
Yup Kang, Sung-Mi Lee, Ik-Rak Jung, Dae Jung Kim, Ji-Hyun Lee, Sung-E Choi, Kwan Woo Lee, Hae Jin Kim, Soojin Lee, Seung Jin Han
Publikováno v:
Molecular and Cellular Endocrinology. 383:48-59
This work was initiated to determine whether toxicity generated through inhibition of mitochondrial fuel metabolism is similar to high glucose/palmitate (HG/PA)-induced glucolipotoxicity. Influx of glucose and free fatty acids into the tricarboxylic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75dcec1a7cb83effda76a6ad48f93163
https://doi.org/10.1016/j.mce.2013.12.002
https://doi.org/10.1016/j.mce.2013.12.002
Autor:
Seung Jin Han, Yup Kang, Ik-Rak Jung, Ji Eun Kwon, Kwan Woo Lee, Hae Jin Kim, Sang-A Yi, Jong Gab Jung, Sung-E Choi, Dae Jung Kim, Maureen Shin, Hyunhee Oh, Seok Youn Kang, Cheol Soo Choi
Publikováno v:
Scientific Reports
SCIENTIFIC REPORTS(6)
SCIENTIFIC REPORTS(6)
Individuals with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) induced by high calorie western diet are characterized by enhanced lipogenesis and gluconeogenesis in the liver. Stimulation of reductive amination may shift tricarb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d91df409fdf270f1121fdc7a2e8e85
Autor:
Sung-Mi Lee, Soojin Lee, Yup Kang, Ik-Rak Jung, Kwan Woo Lee, Ji-Hyun Lee, Jung-Jin Lee, Sung-E Choi
Publikováno v:
Molecular and Cellular Biochemistry. 354:207-217
Fatty acid-induced cytotoxicity is believed to recapitulate lipotoxicity seen in obese type-2 diabetes, and, thus, contribute to beta cell loss in the disease. These studies were initiated to determine whether the Toll-like receptor (TLR) signaling p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dacd4265a008d6d81aeda755269df47
https://doi.org/10.1007/s11010-011-0820-7
https://doi.org/10.1007/s11010-011-0820-7
Autor:
Young Soo Kim, Yup Kang, Sung E. Choi, Ji-Hyun Lee, Youn Jung Lee, Kwan Woo Lee, Soojin Lee, Ik Rak Jung, Hee-Sook Jun, Chan Bae Park
Publikováno v:
Endocrinology. 152:816-827
Saturated fatty acids are generally cytotoxic to β-cells. Accumulation of lipid intermediates and subsequent activation of lipid-mediated signals has been suggested to play a role in fatty acid-induced toxicity. To determine the effects of lipid met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b024f3d99aff057f8d593397e276cee
https://doi.org/10.1210/en.2010-0924
https://doi.org/10.1210/en.2010-0924