Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ik-Hyeon Paik"'
Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS
Autor:
Pachamuthu Kandasamy, Yuanjing Liu, Vincent Aduda, Sandheep Akare, Rowshon Alam, Amy Andreucci, David Boulay, Keith Bowman, Michael Byrne, Megan Cannon, Onanong Chivatakarn, Juili Dilip Shelke, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Sarah Lamore, Muriel Lemaitre, Xuena Lin, Kenneth Longo, Richard Looby, Subramanian Marappan, Jake Metterville, Susovan Mohapatra, Bridget Newman, Ik-Hyeon Paik, Saurabh Patil, Erin Purcell-Estabrook, Mamoru Shimizu, Pochi Shum, Stephany Standley, Kris Taborn, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Elena Dale, Chandra Vargeese
Publikováno v:
Nucleic Acids Research. 50:5401-5423
Attaining sufficient tissue exposure at the site of action to achieve the desired pharmacodynamic effect on a target is an important determinant for any drug discovery program, and this can be particularly challenging for oligonucleotides in deep tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bd2c8b0ca0bc373823740210c986ec
https://doi.org/10.1093/nar/gkac037
https://doi.org/10.1093/nar/gkac037
Autor:
Pachamuthu Kandasamy, Graham McClorey, Mamoru Shimizu, Nayantara Kothari, Rowshon Alam, Naoki Iwamoto, Jayakanthan Kumarasamy, Gopal R Bommineni, Adam Bezigian, Onanong Chivatakarn, David C D Butler, Michael Byrne, Katarzyna Chwalenia, Kay E Davies, Jigar Desai, Juili Dilip Shelke, Ann F Durbin, Ruth Ellerington, Ben Edwards, Jack Godfrey, Andrew Hoss, Fangjun Liu, Kenneth Longo, Genliang Lu, Subramanian Marappan, Jacopo Oieni, Ik-Hyeon Paik, Erin Purcell Estabrook, Chikdu Shivalila, Maeve Tischbein, Tomomi Kawamoto, Carlo Rinaldi, Joana Rajão-Saraiva, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Cong Zhou, Jason Zhang, Luciano Apponi, Matthew J A Wood, Chandra Vargeese
Publikováno v:
Nucleic acids research. 50(10)
Although recent regulatory approval of splice-switching oligonucleotides (SSOs) for the treatment of neuromuscular disease such as Duchenne muscular dystrophy has been an advance for the splice-switching field, current SSO chemistries have shown limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4563bb9a20823ec7e04b7dd2e362f73
https://pubmed.ncbi.nlm.nih.gov/35061895
https://pubmed.ncbi.nlm.nih.gov/35061895
Autor:
Andrew D. Hamilton, Yang Wang, Robert M. Enick, In Chul Kim, Jacob M. Crosthwaite, Eric J. Beckman, Mark C. Thies, J. Karl Johnson, Ik Hyeon Paik, Lei Hong, Deepak Tapriyal
Publikováno v:
The Journal of Physical Chemistry B. 113:14971-14980
Ab initio molecular modeling is used to design nonfluorous polymers that are potentially soluble in liquid CO2. We have used calculations to design three nonfluorous compounds meant to model the monomeric repeat units of polymers that exhibit multipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60de5e85a44a29a83b9a7244cca6633a
https://doi.org/10.1021/jp9073812
https://doi.org/10.1021/jp9073812
Publikováno v:
Angewandte Chemie. 119:3348-3351
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74d4e05a49148a46cbd6f25abff6caf4
https://doi.org/10.1002/ange.200604844
https://doi.org/10.1002/ange.200604844
Publikováno v:
Angewandte Chemie International Edition. 46:3284-3287
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d071e9212accd22269e32d802a73bef
https://doi.org/10.1002/anie.200604844
https://doi.org/10.1002/anie.200604844
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 2:573-583
Chemical insights into artemisinin's biological mechanism of action have allowed rational design of some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarizes recent achievements in this area
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f819249bd6a035c16edb6dd19fbefa0
https://doi.org/10.2174/1389557023405620
https://doi.org/10.2174/1389557023405620
Publikováno v:
International Journal for Parasitology. 32:1661-1667
Mechanism-based rational design and gram-scale chemical synthesis have produced some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarises recent achievements in this area of peroxide drug de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0871fa0cbd5a1085e0a2b39356b6b6c8
https://doi.org/10.1016/s0020-7519(02)00195-9
https://doi.org/10.1016/s0020-7519(02)00195-9
Autor:
Suji Xie, Ik-Hyeon Paik, Theresa A. Shapiro, Kristina Borstnik, Heung Bae Jeon, Gary H. Posner, Poonsakdi Ploypradith
Publikováno v:
Journal of Medicinal Chemistry. 45:3824-3828
Short chemical syntheses of four new antimalarial trioxanes are presented, starting with inexpensive and commercially available cyclohexanone. Almost exclusive formation of the trioxane 12alpha-stereoisomers simplifies product purification. Carboxyph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7086ef5c7882d20067e19259db27ef08
https://doi.org/10.1021/jm020210h
https://doi.org/10.1021/jm020210h
Autor:
and Adebusola Alagbala, Andrew J. McRiner, Suji Xie, Ik-Hyeon Paik, Barbara A. Foster, Gary H. Posner, Surojit Sur, Theresa A. Shapiro, Kristina Borstnik
Publikováno v:
Journal of Medicinal Chemistry. 47:1299-1301
In only four chemical steps from naturally occurring artemisinin (1), trioxane dimers 6 and 7 were prepared on a multigram scale in overall 32-44% yields. In mice, both isonicotinate N-oxide dimer 6 and isobutyric acid dimer 7 were considerably more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91b18b41d61fa1fef8330c4d6df559a
https://doi.org/10.1021/jm0303711
https://doi.org/10.1021/jm0303711
Autor:
Ik-Hyeon Paik, Amy A. Sarjeant, and Astrid C. Baege, Suji Xie, Tanzina Labonte, Theresa A. Shapiro, Gary H. Posner
Publikováno v:
Journal of medicinal chemistry. 49(9)
In only two steps and in 63% overall yield, naturally occurring 1,2,4-trioxane artemisinin (1) was converted into C-10-carba trioxane conjugated diene dimer 4. This new dimer was then transformed easily in one additional 4 + 2-cycloaddition step into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be8be32c247482c10bfe359f908f087
https://pubmed.ncbi.nlm.nih.gov/16640333
https://pubmed.ncbi.nlm.nih.gov/16640333