Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Ijeoma F Uchegbu"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 829 (2024)
Glioblastoma multiforme (GBM) is a fast-growing and aggressive brain tumour, which remains largely resistant to treatment; the prognosis for patients is poor, with a median survival time of about 12–18 months, post diagnosis. In an effort to bring
Externí odkaz:
https://doaj.org/article/c454db06fb13469497ffbb2b89882b45
Autor:
Krzysztof Pyrć, Aleksandra Milewska, Emilia Barreto Duran, Paweł Botwina, Agnieszka Dabrowska, Malwina Jedrysik, Malgorzata Benedyk, Rui Lopes, Alejandro Arenas-Pinto, Moutaz Badr, Ryan Mellor, Tammy L. Kalber, Delmiro Fernandez-Reyes, Andreas G. Schätzlein, Ijeoma F. Uchegbu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract There are currently no cures for coronavirus infections, making the prevention of infections the only course open at the present time. The COVID-19 pandemic has been difficult to prevent, as the infection is spread by respiratory droplets an
Externí odkaz:
https://doaj.org/article/ece9c022e8864d0d9a352e3b870f4e3d
Autor:
Yvonne Lerchbammer-Kreith, Michaela Hejl, Nadine S. Sommerfeld, Xian Weng-Jiang, Uchechukwu Odunze, Ryan D. Mellor, David G. Workman, Michael A. Jakupec, Andreas G. Schätzlein, Ijeoma F. Uchegbu, Mathea S. Galanski, Bernhard K. Keppler
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 1027 (2023)
Quaternary ammonium palmitoyl glycol chitosan (GCPQ) has already shown beneficial drug delivery properties and has been studied as a carrier for anticancer agents. Consequently, we synthesised cytotoxic platinum(IV) conjugates of cisplatin, carboplat
Externí odkaz:
https://doaj.org/article/b83c0dfc255c45309374a06652151faa
Autor:
Yvonne Lerchbammer-Kreith, Nadine S. Sommerfeld, Klaudia Cseh, Xian Weng-Jiang, Uchechukwu Odunze, Andreas G. Schätzlein, Ijeoma F. Uchegbu, Mathea S. Galanski, Michael A. Jakupec, Bernhard K. Keppler
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1050 (2023)
A new class of anticancer prodrugs was designed by combining the cytotoxicity of platinum(IV) complexes and the drug carrier properties of glycol chitosan polymers: Unsymmetrically carboxylated platinum(IV) analogues of cisplatin, carboplatin and oxa
Externí odkaz:
https://doaj.org/article/2c1521fc3aa645ab91b5d4aefaa51a8a
Autor:
Abdullah A. Alamoudi, Paula A. Méndez, David Workman, Andreas G. Schätzlein, Ijeoma F. Uchegbu
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2182 (2022)
Therapeutic gene silencing in the brain is usually achieved using highly invasive intracranial administration methods and/or comparatively toxic vectors. In this work, we use a relatively biocompatible vector: poly(ethylene glycol) star-shaped polyme
Externí odkaz:
https://doaj.org/article/3ed58491d23a462b9a8ddb1e2b3de4af
Autor:
Ryan D. Mellor, Ijeoma F. Uchegbu
Publikováno v:
Nanomaterials, Vol 12, Iss 14, p 2476 (2022)
Gold nanoparticles (AuNPs) are continuing to gain popularity in the field of nanotechnology. New methods are continuously being developed to tune the particles’ physicochemical properties, resulting in control over their biological fate and applica
Externí odkaz:
https://doaj.org/article/e78da45fd9f34864926c432a773e5b48
Autor:
Asya I. Petkova, Ilona Kubajewska, Alexandra Vaideanu, Andreas G. Schätzlein, Ijeoma F. Uchegbu
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1136 (2022)
Gene delivery to the cerebral cortex is challenging due to the blood brain barrier and the labile and macromolecular nature of DNA. Here we report gene delivery to the cortex using a glycol chitosan—DNA polyplex (GCP). In vitro, GCPs carrying a rep
Externí odkaz:
https://doaj.org/article/9237c5f04a7d4947b7510f896893d93c
Autor:
Abdulghani Alakkad, Paul Stapleton, Corinna Schlosser, Sudaxshina Murdan, Uchechukwu Odunze, Andreas Schatzlein, Ijeoma F. Uchegbu
Publikováno v:
Pathogens, Vol 11, Iss 1, p 73 (2022)
Purpose: Chronic infections of Candida albicans are characterised by the embedding of budding and entwined filamentous fungal cells into biofilms. The biofilms are refractory to many drugs and Candida biofilms are associated with ocular fungal infect
Externí odkaz:
https://doaj.org/article/05c35bbe865b4586b5e2fc64aab8b523
Publikováno v:
Nanomaterials, Vol 11, Iss 9, p 2181 (2021)
Gold nanoparticles (AuNPs) are used experimentally for non-invasive in vivo Raman monitoring because they show a strong absorbance in the phototherapeutic window (650–850 nm), a feature that is accompanied by a particle size in excess of 100 nm. Ho
Externí odkaz:
https://doaj.org/article/80d8af2b1e734353865fae07f503792b
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 744 (2021)
Commercial topical ocular formulations for hydrophobic actives rely on the use of suspensions or oil in water emulsions and neither of these formulation modalities adequately promote drug penetration into ocular tissues. Using the ocular relevant hyd
Externí odkaz:
https://doaj.org/article/2dd186d8fddc4fa584623b46ceeff20e