Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Iiro Taneli Helenius"'
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1666 (2021)
A better understanding of the metabolic constraints of a tumor may lead to more effective anticancer treatments. Evidence has emerged in recent years shedding light on a crucial aspartate dependency of many tumor types. As a precursor for nucleotide
Externí odkaz:
https://doaj.org/article/062bd5e7400a4d539b3f16dfaf731977
Autor:
István Vadász, Laura A Dada, Arturo Briva, Iiro Taneli Helenius, Kfir Sharabi, Lynn C Welch, Aileen M Kelly, Benno A Grzesik, G R Scott Budinger, Jing Liu, Werner Seeger, Greg J Beitel, Yosef Gruenbaum, Jacob I Sznajder
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46696 (2012)
Elevated CO(2) levels (hypercapnia) occur in patients with respiratory diseases and impair alveolar epithelial integrity, in part, by inhibiting Na,K-ATPase function. Here, we examined the role of c-Jun N-terminal kinase (JNK) in CO(2) signaling in m
Externí odkaz:
https://doaj.org/article/592b2c1115c447aa951641a042118dd3
Autor:
Jing-Ruey Joanna Yeh, Edward Chouchani, Othon Iliopoulos, Andrew M. Intlekofer, Eugene Rhee, Benjamin Olenchock, Kyung Bo Kim, Surendra Punganuru, Michelle L. Kelley, Ana M. Metelo, Yan Liu, Yiyun Zhang, Evanna Mills, Wen Zhou, Iiro Taneli Helenius, Hanumantha Rao Madala
Figure S1-S18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c45f86d5b8c3f5ad72a8f51f0775fb
https://doi.org/10.1158/0008-5472.22426108
https://doi.org/10.1158/0008-5472.22426108
Autor:
Jing-Ruey Joanna Yeh, Edward Chouchani, Othon Iliopoulos, Andrew M. Intlekofer, Eugene Rhee, Benjamin Olenchock, Kyung Bo Kim, Surendra Punganuru, Michelle L. Kelley, Ana M. Metelo, Yan Liu, Yiyun Zhang, Evanna Mills, Wen Zhou, Iiro Taneli Helenius, Hanumantha Rao Madala
Under conditions of inherent or induced mitochondrial dysfunction, cancer cells manifest overlapping metabolic phenotypes, suggesting that they may be targeted via a common approach. Here, we use multiple oxidative phosphorylation (OXPHOS)–competen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de16a69c1792a4adfa552b1373b28ee
https://doi.org/10.1158/0008-5472.c.6512227.v1
https://doi.org/10.1158/0008-5472.c.6512227.v1
Autor:
Jing-Ruey Joanna Yeh, Edward Chouchani, Othon Iliopoulos, Andrew M. Intlekofer, Eugene Rhee, Benjamin Olenchock, Kyung Bo Kim, Surendra Punganuru, Michelle L. Kelley, Ana M. Metelo, Yan Liu, Yiyun Zhang, Evanna Mills, Wen Zhou, Iiro Taneli Helenius, Hanumantha Rao Madala
Supplemental Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab83fa78c207a301ec2287339af1ad1
https://doi.org/10.1158/0008-5472.22426111
https://doi.org/10.1158/0008-5472.22426111
Autor:
Evanna L. Mills, Benjamin A. Olenchock, Edward T. Chouchani, Surendra R. Punganuru, Wen Zhou, Yan Liu, Ana M. Metelo, Michelle L. Kelley, Andrew M. Intlekofer, Iiro Taneli Helenius, Yiyun Zhang, Othon Iliopoulos, Eugene P. Rhee, Jing-Ruey J. Yeh, Hanumantha Rao Madala, Kyung Bo Kim
Publikováno v:
Cancer Res
Under conditions of inherent or induced mitochondrial dysfunction, cancer cells manifest overlapping metabolic phenotypes, suggesting that they may be targeted via a common approach. Here, we use multiple oxidative phosphorylation (OXPHOS)–competen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b9ed999e56b7e08a5bf81aeb2ec0f6
https://doi.org/10.1158/0008-5472.can-20-0246
https://doi.org/10.1158/0008-5472.can-20-0246
Autor:
Cormac T. Taylor, G. R. Scott Budinger, Ankit Bharat, Iiro Taneli Helenius, Yosef Gruenbaum, Laura A. Dada, Melanie B. Edwards, Sergejs Berdnikovs, Cara J. Gottardi, Peter H. S. Sporn, István Vadász, Kfir Sharabi, Martín Angulo, Gustavo A. Nader, Emilia Lecuona, Naftali Kaminski, Jacob I. Sznajder, Eoin P. Cummins, Masahiko Shigemura, Lynn C. Welch, Greg J. Beitel, S. Marina Casalino-Matsuda
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
Scientific Reports
Carbon dioxide (CO2) is sensed by cells and can trigger signals to modify gene expression in different tissues leading to changes in organismal functions. Despite accumulating evidence that several pathways in various organisms are responsive to CO2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7573282d941fde56184a8ff5ded4361
http://link.springer.com/article/10.1038/s41598-019-54683-0
http://link.springer.com/article/10.1038/s41598-019-54683-0
Publikováno v:
Biomolecules
Biomolecules, Vol 11, Iss 1666, p 1666 (2021)
Biomolecules, Vol 11, Iss 1666, p 1666 (2021)
A better understanding of the metabolic constraints of a tumor may lead to more effective anticancer treatments. Evidence has emerged in recent years shedding light on a crucial aspartate dependency of many tumor types. As a precursor for nucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf8920b7bd565e01181e020752f69a2
http://europepmc.org/articles/PMC8615858
http://europepmc.org/articles/PMC8615858
Autor:
Aisha Nair, Greg J. Beitel, Jacob I. Sznajder, Iiro Taneli Helenius, Humberto E. Trejo Bittar, Peter H. S. Sporn
Publikováno v:
SLAS Discovery. 21:363-371
Patients with severe lung disease may develop hypercapnia, elevation of the levels of CO2 in the lungs and blood, which is associated with increased risk of death, often from infection. To identify compounds that ameliorate the adverse effects of hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9798cf98ee7c34dbbbe50934a444362
https://doi.org/10.1177/1087057115624091
https://doi.org/10.1177/1087057115624091
Autor:
Greg J. Beitel, S. Marina Casalino-Matsuda, Jacob I. Sznajder, Yong Jae Kwon, Thomas Krupinski, Ryan J. Haake, Iiro Taneli Helenius, Jennifer A. Hu, Peter H. S. Sporn
Publikováno v:
The Journal of Immunology. 196:655-667
Hypercapnia, elevated partial pressure of CO2 in blood and tissue, develops in many patients with chronic severe obstructive pulmonary disease and other advanced lung disorders. Patients with advanced disease frequently develop bacterial lung infecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671f1e8af0df9b24a74797cf4b9d4ca7
https://doi.org/10.4049/jimmunol.1501708
https://doi.org/10.4049/jimmunol.1501708