Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Iih-Nan Chou"'
Publikováno v:
Journal of Biological Chemistry. 282:25322-25337
Lysyl oxidase (LO) stabilizes the extracellular matrix by cross-linking collagen and elastin. To assess the transcriptional regulation of LO, we cloned the 5′-flanking region with 3,979 bp of the rat LO gene. LO transcription started at multiple si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebae47982c9482705ac74132fc2363f9
https://doi.org/10.1074/jbc.m610108200
https://doi.org/10.1074/jbc.m610108200
Autor:
Phillip J. Stone, Paul Toselli, Yinzhi Zhao, Iih-Nan Chou, Denise K. Chou, Wande Li, Song Gao
Publikováno v:
Toxicological Sciences. 99:267-276
To probe mechanisms of cadmium (Cd) damage to the lung extracellular matrix (ECM), we developed Cd-resistant (CdR) rat lung fibroblasts (RFL6) by incubation with graded concentrations of Cd. CdR cells downregulated lysyl oxidase (LO), a copper (Cu)-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb170190883fae56d9ba02329167ce71
https://doi.org/10.1093/toxsci/kfm158
https://doi.org/10.1093/toxsci/kfm158
Publikováno v:
Toxicological Sciences. 90:478-489
Copper (Cu)-dependent lysyl oxidase (LO) catalyzes crosslinking of collagen and elastin stabilizing the extracellular matrix (ECM). Chronic inhalation of cadmium (Cd), a toxic metal, induces emphysema. To probe mechanisms of Cd injury to the lung, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ec340d950acfcba14a76d902a71840
https://doi.org/10.1093/toxsci/kfj112
https://doi.org/10.1093/toxsci/kfj112
Publikováno v:
Toxicology and Applied Pharmacology. 193:202-208
Microtubule (MT) assembly in vitro is accompanied by hydrolysis of tubulin-bound GTP at E-site. Ni2+, a human carcinogen, has been shown to markedly perturb the MT system in cultured cells and enhance MT assembly in vitro. To further probe the mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a30bc5024c48b9979ef99cd1c44d23
https://doi.org/10.1016/j.taap.2003.07.001
https://doi.org/10.1016/j.taap.2003.07.001
Autor:
Sandy J. Li, Guanmei Liu, Wande Li, Matthew A. Nugent, Iih-Nan Chou, Yinzhi Zhao, Anne N. Chau, H. Kagan
Publikováno v:
Journal of Cellular Biochemistry. 88:152-164
Lysyl oxidase (LO) plays a central role in the crosslinking of collagen and elastin in the extracellular matrix. Here we demonstrate that basic fibroblast growth factor (bFGF), a polypeptide which regulates proliferation, differentiation, and migrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9195adaf5e9560ede6e205d43eb2f19
https://doi.org/10.1002/jcb.10304
https://doi.org/10.1002/jcb.10304
Publikováno v:
Journal of Cellular Biochemistry. 78:550-557
Lysyl oxidase (LO), an enzyme secreted by vascular smooth muscle cells (VSMC), initiates the covalent crosslinking of polypeptide chains within collagen and elastin. The present study reveals that purified LO strongly induces directional migration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a19013475b556b0174001610dba128d
https://doi.org/10.1002/1097-4644(20000915)78:4<550::aid-jcb4>3.0.co
https://doi.org/10.1002/1097-4644(20000915)78:4<550::aid-jcb4>3.0.co
Publikováno v:
Toxicology and Applied Pharmacology. 126:114-123
To understand further the mechanisms of cadmium toxicity, cytoskeletal organization and homeostasis of cellular thiols were examined in cadmium-resistant cells isolated from Swiss mouse 3T3 cells by incubation in graded concentrations of CdCl2 (Cd2+)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d42ffbd1123bdba475d4db61ff4fa3f
https://doi.org/10.1006/taap.1994.1097
https://doi.org/10.1006/taap.1994.1097
Autor:
Wande Li, Iih-Nan Chou
Publikováno v:
Toxicology and Applied Pharmacology. 114:132-139
The effects of As3+ (NaAsO2) on the microtubule and microfilament organization, cytoskeletal protein synthesis, cytoskeletal and cytosolic (soluble) protein sulfhydryls, and cellular glutathione (GSH) levels were examined in Swiss 3T3 mouse cells. Ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed1ce60587b13629494bdedd5fab3d6
https://doi.org/10.1016/0041-008x(92)90105-2
https://doi.org/10.1016/0041-008x(92)90105-2
Publikováno v:
Journal of Investigative Dermatology. 97(6):985-994
Indirect immunofluorescence microscopy has been used to investigate the coordinated reorganization of microtubules, microfilaments, and keratin intermediate filaments in cultured human epidermal keratinocytes following a switch from low-Ca++ (0.15 mM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993da72b6f1800daf02a9c276b7a6fb7
Autor:
Glen B. Zamansky, Iih-Nan Chou
Publikováno v:
Photochemistry and Photobiology. 52:903-906
Fluorescence microscopy has been utilized to investigate the effects of UV irradiation on the organization of keratin intermediate filaments in normal human epidermal keratinocytes. Sun lamp irradiation induced the condensation of keratin intermediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f833d078f01cc81e1659edb5bc2eef42
https://doi.org/10.1111/j.1751-1097.1990.tb08700.x
https://doi.org/10.1111/j.1751-1097.1990.tb08700.x