Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Ihor R. Lemischka"'
Autor:
Amin R. Mazloom, Huilei Xu, Jaume Reig-Palou, Ana Vasileva, Angel-Carlos Román, Sonia Mulero-Navarro, Ihor R. Lemischka, Ana Sevilla
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Characterization of pluripotent states, in which cells can both self-renew or differentiate, with the irreversible loss of pluripotency, are important research areas in developmental biology. Although microRNAs (miRNAs) have been shown to play a rele
Externí odkaz:
https://doaj.org/article/9157c4114685456a9a9eefd77bed681f
Autor:
Ana Sevilla, Dimitri Papatsenko, Amin R. Mazloom, Huilei Xu, Ana Vasileva, Richard D. Unwin, Gary LeRoy, Edward Y. Chen, Francine E. Garrett-Bakelman, Dung-Fang Lee, Benjamin Trinite, Ryan L. Webb, Zichen Wang, Jie Su, Julian Gingold, Ari Melnick, Benjamin A. Garcia, Anthony D. Whetton, Ben D. MacArthur, Avi Ma’ayan, Ihor R. Lemischka
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Cell fate decisions during development are governed by multi-factorial regulatory mechanisms including chromatin remodeling, DNA methylation, binding of transcription factors to specific loci, RNA transcription and protein synthesis. However, the mec
Externí odkaz:
https://doaj.org/article/67b02d769bf444e29916c542735c28dd
Autor:
An Xu, Mo-Fan Huang, Dandan Zhu, Julian A. Gingold, Danielle A. Bazer, Betty Chang, Donghui Wang, Chien-Chen Lai, Ihor R. Lemischka, Ruiying Zhao, Dung-Fang Lee
Publikováno v:
Frontiers in Genetics, Vol 11 (2021)
Osteosarcoma is one of the most frequent common primary malignant tumors in childhood and adolescence. Long non-coding RNAs (lncRNAs) have been reported to regulate the initiation and progression of tumors. However, the exact molecular mechanisms inv
Externí odkaz:
https://doaj.org/article/9e84eebc8a7546098fc8ae81b9b148a8
Publikováno v:
Stem Cell Research, Vol 29, Iss , Pp 180-188 (2018)
Embryonic stem cells (ESCs) can proliferate and self-renew, maintaining their pluripotency status in vitro for a long period of time. Pluripotent states of ESCs in vitro are supported by a network of signaling, transcriptional and epigenetic regulato
Externí odkaz:
https://doaj.org/article/dcd61e01223d4604b5b0dc905f9b1dc8
Autor:
Ana G. Freire, Avinash Waghray, Francisca Soares-da-Silva, Tatiana P. Resende, Dung-Fang Lee, Carlos-Filipe Pereira, Diana S. Nascimento, Ihor R. Lemischka, Perpétua Pinto-do-Ó
Publikováno v:
Stem Cell Reports, Vol 9, Iss 1, Pp 136-148 (2017)
Notch signaling plays a role in specifying a cardiac fate but the downstream effectors remain unknown. In this study we implicate the Notch downstream effector HES5 in cardiogenesis. We show transient Hes5 expression in early mesoderm of gastrulating
Externí odkaz:
https://doaj.org/article/eceac6fc3a3d434694b5d0d34bb986dd
Autor:
Andreia M. Gomes, Ilia Kurochkin, Betty Chang, Michael Daniel, Kenneth Law, Namita Satija, Alexander Lachmann, Zichen Wang, Lino Ferreira, Avi Ma’ayan, Benjamin K. Chen, Dmitri Papatsenko, Ihor R. Lemischka, Kateri A. Moore, Carlos-Filipe Pereira
Publikováno v:
Cell Reports, Vol 25, Iss 10, Pp 2821-2835.e7 (2018)
Summary: During development, hematopoietic stem and progenitor cells (HSPCs) arise from specialized endothelial cells by a process termed endothelial-to-hematopoietic transition (EHT). The genetic program driving human HSPC emergence remains largely
Externí odkaz:
https://doaj.org/article/59503b1ffe32437e98c4083456bd02ef
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Loss-of-function approaches are fundamental for dissecting the roles played by genes but methods to simultaneously perturb several proteins in the same mammalian cell are scarce. Here the authors harness the plant auxin and jasmonate hormone-degradat
Externí odkaz:
https://doaj.org/article/bf9049e062094f6ba57a70054e8f6541
Autor:
Sonia Mulero-Navarro, Ana Sevilla, Angel C. Roman, Dung-Fang Lee, Sunita L. D’Souza, Sherly Pardo, Ilan Riess, Jie Su, Ninette Cohen, Christoph Schaniel, Nelson A. Rodriguez, Alessia Baccarini, Brian D. Brown, Hélène Cavé, Aurélie Caye, Marion Strullu, Safak Yalcin, Christopher Y. Park, Perundurai S. Dhandapany, Ge Yongchao, Lisa Edelmann, Sawsan Bahieg, Patrick Raynal, Elisabetta Flex, Marco Tartaglia, Kateri A. Moore, Ihor R. Lemischka, Bruce D. Gelb
Publikováno v:
Cell Reports, Vol 13, Iss 3, Pp 504-515 (2015)
Somatic PTPN11 mutations cause juvenile myelomonocytic leukemia (JMML). Germline PTPN11 defects cause Noonan syndrome (NS), and specific inherited mutations cause NS/JMML. Here, we report that hematopoietic cells differentiated from human induced plu
Externí odkaz:
https://doaj.org/article/9780445694cc446b983bfa504b8a9a71
Autor:
Dmitri Papatsenko, Henia Darr, Ivan V. Kulakovskiy, Avinash Waghray, Vsevolod J. Makeev, Ben D. MacArthur, Ihor R. Lemischka
Publikováno v:
Stem Cell Reports, Vol 5, Iss 2, Pp 207-220 (2015)
Analyses of gene expression in single mouse embryonic stem cells (mESCs) cultured in serum and LIF revealed the presence of two distinct cell subpopulations with individual gene expression signatures. Comparisons with published data revealed that cel
Externí odkaz:
https://doaj.org/article/2608ee7f44894f8f8c4656c60cd78e5d
Autor:
Avinash Waghray, Néstor Saiz, Anitha D. Jayaprakash, Ana G. Freire, Dmitri Papatsenko, Carlos-Filipe Pereira, Dung-Fang Lee, Ran Brosh, Betty Chang, Henia Darr, Julian Gingold, Kevin Kelley, Christoph Schaniel, Anna-Katerina Hadjantonakis, Ihor R. Lemischka
Publikováno v:
Stem Cell Reports, Vol 5, Iss 1, Pp 97-110 (2015)
Tbx3, a member of the T-box family, plays important roles in development, stem cells, nuclear reprogramming, and cancer. Loss of Tbx3 induces differentiation in mouse embryonic stem cells (mESCs). However, we show that mESCs exist in an alternate sta
Externí odkaz:
https://doaj.org/article/14455f8caaf74166a117e2ebbcc23c4a