Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ihor O. Pokotylo"'
Autor:
Pavlo V. Zadorozhnii, Ihor O. Pokotylo, Vadym V. Kiselev, Oxana V. Okhtina, Aleksandr V. Kharchenko
Publikováno v:
ADMET and DMPK, Vol 7, Iss 2, Pp 140-150 (2019)
The phenomenon of the endoplasmic reticulum (ER) stress as a molecular pathophysiological process underlies diseases as cancer, diabetes mellitus, myocardial infarction, neurodegenerative disorders, diseases of the urinary system, disorders associate
Externí odkaz:
https://doaj.org/article/b91c10d58aae4c0fbc38ac964ece88cc
Autor:
Ihor O. Pokotylo1, Pavlo V. Zadorozhnii1 torfp@i.ua, Vadym V. Kiselev1, Aleksandr V. Kharchenko1
Publikováno v:
Journal of Heterocyclic Chemistry. Oct2023, Vol. 60 Issue 10, p1799-1808. 10p.
Publikováno v:
Structural Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::358abd660d6633020eee8c0b7926867a
https://doi.org/10.1007/s11224-023-02184-2
https://doi.org/10.1007/s11224-023-02184-2
Autor:
Oxana V. Okhtina, Vadym V. Kiselev, Ihor O. Pokotylo, Aleksandr V. Kharchenko, Pavlo V. Zadorozhnii
Publikováno v:
Heterocyclic Communications, Vol 25, Iss 1, Pp 130-137 (2019)
Based on readily available N-(2,2,2-trichloro-1-hydroxyethyl)carboxamides, N-(2,2,2-trichloro-1-(3-(3-mercapto-4H-1,2,4-triazol-4-yl)thioureido)ethyl) carboxamides, dehydrosulfurization–under the influence of excess HgO–led to the formation of N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9d4ca94fc01788bbf72247a4ef9535
https://doi.org/10.1515/hc-2019-0020
https://doi.org/10.1515/hc-2019-0020
Autor:
Oxana V. Okhtina, Pavlo V. Zadorozhnii, Aleksandr V. Kharchenko, Vadym V. Kiselev, Ihor O. Pokotylo
Publikováno v:
Acta Chemica Iasi, Vol 27, Iss 1, Pp 65-72 (2019)
Based on the readily available N-(2,2-dichloro-1-(2-(4-methylbenzoyl)-hydrazine-1-carbothioamido)ethyl)benzamide, the corresponding N-(2,2-dichloro-1-((5-(p-tolyl)-1,3,4-oxadiazol-2-yl)amino)ethyl)benzamide and 5-(p-tolyl)-1,3,4-thiadiazol-2-amine we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972cf501c59cc544b125332ab7fb5585
https://doaj.org/article/fe655789fb754e60b0074920769025a9
https://doaj.org/article/fe655789fb754e60b0074920769025a9
Autor:
Pavlo V. Zadorozhnii, Aleksandr V. Kharchenko, Oxana V. Okhtina, Vadym V. Kiselev, Ihor O. Pokotylo
Publikováno v:
Heterocyclic Communications. 24:273-278
The mass spectrometric fragmentation of 6-(4-chlorophenyl)-N-aryl-4-(trichloromethyl)-4H-1,3,5-oxadiazin-2-amines was studied under fast-atom bombardment (FAB) conditions. To simplify the interpretation of the mass spectra, a number of new 4H-1,3,5-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fefc4d3f04d51b7a674e2f8f7603d83
https://doi.org/10.1515/hc-2018-0082
https://doi.org/10.1515/hc-2018-0082
Publikováno v:
Chemical Data Collections. :62-66
A new procedure for the synthesis of N-(2,2,2-trichloro-1-hydroxyethyl)carboxamides - “chloralcarboxamides”, condensation products of chloral hydrate with carboxylic acid amides, has been proposed. In addition, the use of any solvents has been ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99db0eccaf9530238aadef6f1a758059
https://doi.org/10.1016/j.cdc.2018.04.002
https://doi.org/10.1016/j.cdc.2018.04.002
Publikováno v:
Heterocyclic Communications. 23:369-374
A new, simple method for the synthesis of 4H-1,3,5-oxadiazine derivatives was developed based on the dehydrogenation reaction of N-amidoalkylated thioureas with dicyclohexylcarbodiimide. The reaction was carried out in acetonitrile under reflux for 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ec1433407234923a360307ded3856dc
https://doi.org/10.1515/hc-2017-0083
https://doi.org/10.1515/hc-2017-0083
In this study, the antagonistic activity of 6-(4-chlorophenyl)-N-aryl-4-(trichloromethyl)-4H-1,3,5-oxadiazin-2-amines against the vascular endothelial growth factor receptor (VEGFR-1) was analyzed using the PASS system. It was shown that the probabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694db12768765f9b49d507f3ad70f1f1
Autor:
Pavlo V. Zadorozhnii, Ihor O. Pokotylo, Vadym V. Kiselev, Aleksandr V. Kharchenko, Oxana V. Okhtina
In this work, using the ArgusLab 4.0.1 software package, we carried out in silico modeling of A2A receptor antagonists. We proposed N-(1-(benzo[d]thiazol-2-ylamino)-2,2,2-trichloroethyl)carboxamides as potential biologically active substances. Accord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7682c7110b8e963f84e4c3edcc2777a4