Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ihor Arkhypov"'
Autor:
Alisa Lepper, Rebekka Bitsch, Feyza Gül Özbay Kurt, Ihor Arkhypov, Samantha Lasser, Jochen Utikal, Viktor Umansky
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTTreatment with immune checkpoint inhibitors (ICIs) has improved the prognosis of melanoma patients. However, ICIs can cause an overactivation of the immune system followed by diverse immunological side effects known as immune-related adverse
Externí odkaz:
https://doaj.org/article/893060cea3484614bbaea1b3f08fe2b5
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Despite the remarkable success of immune checkpoint inhibitors (ICIs) in melanoma treatment, resistance to them remains a substantial clinical challenge. Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of myeloid cells t
Externí odkaz:
https://doaj.org/article/4b3e03a7c8f1428fab34d0756b6f0292
Autor:
Vera Petrova, Christopher Groth, Rebekka Bitsch, Ihor Arkhypov, Sonja C. S. Simon, Svetlana Hetjens, Verena Müller, Jochen Utikal, Viktor Umansky
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
PurposeAlthough the treatment of advanced melanoma patients with immune checkpoint inhibitors (ICI) significantly increased the therapeutic efficiency, many patients remain resistant to ICI that could be due to immunosuppression mediated by myeloid-d
Externí odkaz:
https://doaj.org/article/d324c9c8d3714b6ab00406112a75e99a
Autor:
Feyza Gül Özbay Kurt, Alisa Lepper, Catharina Gerhards, Mathis Roemer, Samantha Lasser, Ihor Arkhypov, Rebekka Bitsch, Peter Bugert, Peter Altevogt, Cécile Gouttefangeas, Michael Neumaier, Jochen Utikal, Viktor Umansky
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
A gradual decay in humoral and cellular immune responses over time upon SAR1S-CoV-2 vaccination may cause a lack of protective immunity. We conducted a longitudinal analysis of antibodies, T cells, and monocytes in 25 participants vaccinated with mRN
Externí odkaz:
https://doaj.org/article/e41d21c0557941d8b08ab68f4da9209b
Autor:
Wei Li, Jochen Utikal, Xiaoying Hu, Viktor Umansky, Peter Altevogt, Rebekka Bitsch, Samantha Lasser, Alisa Lepper, Ihor Arkhypov, Feyza Gül Özbay Kurt, Daniel Novak, Vera Petrova, Thomas Hielscher, Christopher Groth
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Tumor cells modulate host immunity by secreting extracellular vesicles (EV) and soluble factors. Their interactions with myeloid cells lead to the generation of myeloid-derived suppressor cells (MDSC), which inhibit the antitumor function
Externí odkaz:
https://doaj.org/article/10d86f9094cc4bb59797929bd08f5feb
Autor:
Ihor Arkhypov, Samantha Lasser, Vera Petrova, Rebekka Weber, Christopher Groth, Jochen Utikal, Peter Altevogt, Viktor Umansky
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6319 (2020)
Extracellular vesicles (EV) can carry proteins, RNA and DNA, thus serving as communication tools between cells. Tumor cells secrete EV, which can be taken up by surrounding cells in the tumor microenvironment as well as by cells in distant organs. Tu
Externí odkaz:
https://doaj.org/article/df6e618e1302411da0b84f8b6eb0ed8b
Autor:
Vera Petrova, Ihor Arkhypov, Rebekka Weber, Christopher Groth, Peter Altevogt, Jochen Utikal, Viktor Umansky
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2367 (2020)
Although melanoma is one of the most immunogenic tumors, it has an ability to evade anti-tumor immune responses by exploiting tolerance mechanisms, including negative immune checkpoint molecules. The most extensively studied checkpoints represent cyt
Externí odkaz:
https://doaj.org/article/8e26be3f93c24fa7ac2ad1e75201de26
Autor:
Jochen Utikal, Ihor Arkhypov, Viktor Umansky, Rebekka Weber, Vera Petrova, Peter Altevogt, Christopher Groth
Publikováno v:
Kompass Dermatologie. 8:92-101
Das Melanom gehört zu den am stärksten immunogenen Tumoren. Dennoch ist es in der Lage, sich einer antitumoralen Immunantwort zu entziehen, indem es Toleranzmechanismen, einschließlich negativer Immuncheckpoint-Moleküle, nutzt. Die am umfassendst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f41aca39cfcd95d333300e7b503aa51
https://doi.org/10.1159/000509449
https://doi.org/10.1159/000509449
Autor:
Jennifer Dworacek, Laura Hüser, Aniello Federico, Daniel Novak, Thomas Hielscher, Marlene Vierthaler, Jochen Utikal, Ihor Arkhypov, Karol Granados, Marianthi-Maria Kokkaleniou, Viktor Umansky, Peter Altevogt
Publikováno v:
Cancers
Volume 12
Issue 12
Cancers, Vol 12, Iss 3761, p 3761 (2020)
Volume 12
Issue 12
Cancers, Vol 12, Iss 3761, p 3761 (2020)
Simple Summary The major obstacle for the long-term success of targeted therapies in melanoma is the occurrence of resistance. Here, we present a new mechanism of targeted therapy resistance in melanoma where the treatment with the BRAF inhibitor vem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c879ecd32b8fab2f522aab390c9abed2
https://pubmed.ncbi.nlm.nih.gov/33327495
https://pubmed.ncbi.nlm.nih.gov/33327495
Autor:
Peter Altevogt, Christopher Groth, Samantha Lasser, Rebekka Weber, Jochen Utikal, Vera Petrova, Ihor Arkhypov, Viktor Umansky
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6319, p 6319 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 6319, p 6319 (2020)
Extracellular vesicles (EV) can carry proteins, RNA and DNA, thus serving as communication tools between cells. Tumor cells secrete EV, which can be taken up by surrounding cells in the tumor microenvironment as well as by cells in distant organs. Tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc0b22ab707e362986f91c0d2387cde
http://europepmc.org/articles/PMC7504548
http://europepmc.org/articles/PMC7504548