Multinational proficiency tests for EGFR exon 20 insertions reveal that the assay design matters.

Autor: Ihle MA; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 62, 50924, Cologne, Germany. michaela.ihle@uk-koeln.de., Heydt C; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 62, 50924, Cologne, Germany., Schultheis AM; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 62, 50924, Cologne, Germany., Stöhr R; Institute of Pathology, University Hospital Erlangen, Krankenhausstr. 8-10, 91054, Erlangen, Germany., Haller F; Institute of Pathology, University Hospital Erlangen, Krankenhausstr. 8-10, 91054, Erlangen, Germany., Herold S; Institute of Pathology, Hospital of the Technical University Dresden, Fetscherstr. 74, 01307, Dresden, Germany., Aust D; Institute of Pathology, Hospital of the Technical University Dresden, Fetscherstr. 74, 01307, Dresden, Germany., Dietmaier W; Institute of Pathology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany., Evert M; Institute of Pathology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany., Eszlinger M; Institute of Pathology, University Hospital Halle, Magdeburger Str. 14, 06112, Halle (Saale), Germany., Haak A; Institute of Pathology, University Hospital Halle, Magdeburger Str. 14, 06112, Halle (Saale), Germany., Laßmann S; Institute of Surgical Pathology, Medical Center Freiburg, Breisacherstr. 115a, 79106, Freiburg, Germany., Vorholt D; Janssen-Cilag GmbH, Johnson&Johnson Platz 1, 41470, Neuss, Germany., Breitenbücher F; Janssen-Cilag GmbH, Johnson&Johnson Platz 1, 41470, Neuss, Germany., Werner M; Institute of Surgical Pathology, Medical Center Freiburg, Breisacherstr. 115a, 79106, Freiburg, Germany., Streubel A; Institute of Tissue Diagnostics, MVZ at Helios Klinikum Emil Von Behring, Walterhöferstr. 11, 14165, Berlin, Germany., Mairinger T; Institute of Tissue Diagnostics, MVZ at Helios Klinikum Emil Von Behring, Walterhöferstr. 11, 14165, Berlin, Germany., Grassow-Narlik M; Quality Assurance Initiative Pathology (Qualitätssicherungs-Initiative Pathologie [QuIP®]), Reinhardtstr. 1, 10117, Berlin, Germany., Merkelbach-Bruse S; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 62, 50924, Cologne, Germany.

Publikováno v: Scientific reports [Sci Rep] 2024 Jun 06; Vol. 14 (1), pp. 13069. Date of Electronic Publication: 2024 Jun 06.

Overview of Molecular Detection Technologies for MET in Lung Cancer.

Autor: Heydt C; Faculty of Medicine, Institute of Pathology, University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany., Ihle MA; Faculty of Medicine, Institute of Pathology, University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany., Merkelbach-Bruse S; Faculty of Medicine, Institute of Pathology, University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.

Publikováno v: Cancers [Cancers (Basel)] 2023 May 26; Vol. 15 (11). Date of Electronic Publication: 2023 May 26.

Resistance to MET inhibition in MET-dependent NSCLC and therapeutic activity after switching from type I to type II MET inhibitors.

Autor: Riedel R; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department I of Internal Medicine, Germany; Lung Cancer Group, Cologne, Germany., Fassunke J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Pathology, Molecular Pathology, Germany., Tumbrink HL; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Pathology, Molecular Pathology, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Germany., Scheel AH; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Pathology, Molecular Pathology, Germany., Heydt C; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Pathology, Molecular Pathology, Germany., Hieggelke L; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Pathology, Molecular Pathology, Germany., Scheffler M; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department I of Internal Medicine, Germany; Lung Cancer Group, Cologne, Germany., Heimsoeth A; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Pathology, Molecular Pathology, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Germany., Nogova L; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department I of Internal Medicine, Germany; Lung Cancer Group, Cologne, Germany., Michels S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department I of Internal Medicine, Germany; Lung Cancer Group, Cologne, Germany., Weber JP; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department I of Internal Medicine, Germany; Lung Cancer Group, Cologne, Germany., Fischer RN; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department I of Internal Medicine, Germany; Lung Cancer Group, Cologne, Germany., Eisert A; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department I of Internal Medicine, Germany; Lung Cancer Group, Cologne, Germany., Westphal T; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department I of Internal Medicine, Germany; Lung Cancer Group, Cologne, Germany., Schaufler D; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department I of Internal Medicine, Germany; Lung Cancer Group, Cologne, Germany., Siemanowski J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Pathology, Molecular Pathology, Germany., Ihle MA; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Pathology, Molecular Pathology, Germany., Wagener-Ryczek S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Pathology, Molecular Pathology, Germany., Castiglione R; Institute of Pathology, Klinikum Stuttgart, Stuttgart, Germany., Pappesch R; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Pathology, Molecular Pathology, Germany., Rehker J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Pathology, Molecular Pathology, Germany., Jürgens J; Lung Clinic Merheim, Hospital of the City of Cologne, University of Witten-Herdecke, Germany., Stoelben E; Lung Clinic Merheim, Hospital of the City of Cologne, University of Witten-Herdecke, Germany., Bunck A; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Radiology, Germany., Kobe C; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Nuclear Medicine, Germany., Merkelbach-Bruse S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Pathology, Molecular Pathology, Germany., Sos ML; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Pathology, Molecular Pathology, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne, Germany., Büttner R; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department of Pathology, Molecular Pathology, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne, Germany., Wolf J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology, Department I of Internal Medicine, Germany; Lung Cancer Group, Cologne, Germany. Electronic address: juergen.wolf@uk-koeln.de.

Publikováno v: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2023 Jan; Vol. 179, pp. 124-135. Date of Electronic Publication: 2022 Nov 15.

Co-occurrence of targetable mutations in Non-small cell lung cancer (NSCLC) patients harboring MAP2K1 mutations.

Autor: Scheffler M; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Holzem A; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Kron A; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Nogova L; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Ihle MA; University of Cologne, Cologne Institute of Pathology, Cologne, Germany., von Levetzow C; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Fassunke J; University of Cologne, Cologne Institute of Pathology, Cologne, Germany., Wömpner C; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Bitter E; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Koleczko S; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Abdulla DSY; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Michels S; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Fischer R; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Riedel R; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Weber JP; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Westphal T; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Gerigk U; GFO Clinics Bonn, Marien-Hospital Bonn, Bonn, Germany., Kern J; KWM Missio Clinic, Würzburg, Germany., Kaminsky B; Bethanien Hospital Solingen, Clinic for Pulmonology and Allergology, Solingen, Germany., Randerath W; Bethanien Hospital Solingen, Clinic for Pulmonology and Allergology, Solingen, Germany., Kambartel KO; Bethanien Hospital Moers, Lung Center, Moers, Germany., Merkelbach-Bruse S; University of Cologne, Cologne Institute of Pathology, Cologne, Germany., Büttner R; University of Cologne, Cologne Institute of Pathology, Cologne, Germany., Wolf J; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany. Electronic address: juergen.wolf@uk-koeln.de.

Publikováno v: Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2020 Jun; Vol. 144, pp. 40-48. Date of Electronic Publication: 2020 Apr 24.

K-ras Mutation Subtypes in NSCLC and Associated Co-occuring Mutations in Other Oncogenic Pathways.

Autor: Scheffler M; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Ihle MA; University of Cologne, Cologne Institute of Pathology, Cologne, Germany., Hein R; University of Cologne, Institute of Medical Statistics, Informatics and Epidemiology, Cologne, Germany., Merkelbach-Bruse S; University of Cologne, Cologne Institute of Pathology, Cologne, Germany., Scheel AH; University of Cologne, Cologne Institute of Pathology, Cologne, Germany., Siemanowski J; University of Cologne, Cologne Institute of Pathology, Cologne, Germany., Brägelmann J; University of Cologne, Department for Translational Genomics, Cologne, Germany., Kron A; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Abedpour N; University of Cologne, Department for Translational Genomics, Cologne, Germany., Ueckeroth F; University of Cologne, Cologne Institute of Pathology, Cologne, Germany., Schüller M; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Koleczko S; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Michels S; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Fassunke J; University of Cologne, Cologne Institute of Pathology, Cologne, Germany., Pasternack H; Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck and Research Center Borstel, Leibniz Center for Medicine and Biosciences., Heydt C; University of Cologne, Cologne Institute of Pathology, Cologne, Germany., Serke M; Lung Clinic Hemer, Department for Pulmonology and Thoracic Oncology, Hemer, Germany., Fischer R; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Schulte W; GFO Clinics Bonn, Marien-Hospital Bonn, Bonn, Germany., Gerigk U; GFO Clinics Bonn, Marien-Hospital Bonn, Bonn, Germany., Nogova L; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Ko YD; Evangelical Clinics of Bonn, Johanniter Hospital, Bonn, Germany., Abdulla DSY; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Riedel R; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Kambartel KO; Bethanien Hospital Moers, Lung Center, Moers, Germany., Lorenz J; Hospital Lüdenscheid, Clinic for Pneumology, Internistic Intensive Medicine, Infectiology and Sleep Medicine, Lüdenscheid, Germany., Sauerland I; Hospital Lüdenscheid, Clinic for Pneumology, Internistic Intensive Medicine, Infectiology and Sleep Medicine, Lüdenscheid, Germany., Randerath W; Bethanien Hospital Solingen, Clinic for Pulmonology and Allergology, Solingen, Germany., Kaminsky B; Bethanien Hospital Solingen, Clinic for Pulmonology and Allergology, Solingen, Germany., Hagmeyer L; Bethanien Hospital Solingen, Clinic for Pulmonology and Allergology, Solingen, Germany., Grohé C; Evangelic Lung Clinic Berlin, Department of Respiratory Diseases, Berlin, Germany., Eisert A; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Frank R; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Gogl L; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Schaepers C; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Holzem A; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany., Hellmich M; University of Cologne, Institute of Medical Statistics, Informatics and Epidemiology, Cologne, Germany., Thomas RK; University of Cologne, Department for Translational Genomics, Cologne, Germany., Peifer M; University of Cologne, Department for Translational Genomics, Cologne, Germany., Sos ML; University of Cologne, Department for Translational Genomics, Cologne, Germany., Büttner R; University of Cologne, Cologne Institute of Pathology, Cologne, Germany., Wolf J; University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany. Electronic address: juergen.wolf@uk-koeln.de.

Publikováno v: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2019 Apr; Vol. 14 (4), pp. 606-616. Date of Electronic Publication: 2018 Dec 31.