Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ihle, David"'
Autor:
Kathy Sarris, Philip J. Hajduk, Ihle David C, Diana L. Donnelly-Roberts, Arthur Gomtsyan, Christian Goess, David B. Duignan, Danying Song, Chaohong Sun, Andrea Mcclure, Adrian D. Hobson, Robert H. Stoffel, Anil Vasudevan, John A. Mankovich, Sanjay C. Panchal, A. Chris Krueger, Steven L. Swann, Kenneth M. Comess, Andrew M. Petros, Wilson Noel S, Jill M. Wetter, Paul G. Richardson, Kenton L. Longenecker, Paul M. Jung, Vincent S. Stoll, Amanda W. Dombrowski, Suzanne Mathieu, Justin D. Dietrich, Philip B. Cox
Publikováno v:
Journal of Medicinal Chemistry. 64:417-429
Tumor necrosis factor α (TNFα) is a soluble cytokine that is directly involved in systemic inflammation through the regulation of the intracellular NF-κB and MAPK signaling pathways. The development of biologic drugs that inhibit TNFα has led to
Akademický článek
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Autor:
Ihle David C, Eric R. Goedken, Jonathan S. George, Medha J. Tomlinson, David Banach, Douglas Marcotte, Christopher M. Harris, Bryan A. Fiamengo, Maria A. Argiriadi, Sage E. Foley, Sara Murdock, Mark Michalak, Jeffrey W. Voss, Philip Merta, Kristine E. Frank, Adrian D. Hobson
Publikováno v:
Journal of Biological Chemistry. 290:4573-4589
The action of Janus kinases (JAKs) is required for multiple cytokine signaling pathways, and as such, JAK inhibitors hold promise for treatment of autoimmune disorders, including rheumatoid arthritis, inflammatory bowel disease, and psoriasis. Howeve
Autor:
Dietrich, Justin D., Longenecker, Kenton L., Wilson, Noel S., Goess, Christian, Panchal, Sanjay C., Swann, Steven L., Petros, Andrew M., Hobson, Adrian D., Ihle, David, Song, Danying, Richardson, Paul, Comess, Kenneth M., Cox, Philip B., Dombrowski, Amanda, Sarris, Kathy, Donnelly-Roberts, Diana L., Duignan, David B., Gomtsyan, Arthur, Jung, Paul, Krueger, A. Chris
Publikováno v:
Journal of Medicinal Chemistry; 1/14/2021, Vol. 64 Issue 1, p417-429, 13p