Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ihab S. Darwish"'
Autor:
Janik Engelmann, Jennifer Zarrer, Victoria Gensch, Kristoffer Riecken, Nikolaus Berenbrok, The Vinh Luu, Antonia Beitzen-Heineke, Maria Elena Vargas-Delgado, Klaus Pantel, Carsten Bokemeyer, Somasekhar Bhamidipati, Ihab S. Darwish, Esteban Masuda, Tal Burstyn-Cohen, Emily J. Alberto, Sourav Ghosh, Carla Rothlin, Eric Hesse, Hanna Taipaleenmäki, Isabel Ben-Batalla, Sonja Loges
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The TAM family of receptor tyrosine kinases exerts pleiotropic functions in health and disease. Here, the authors show that TAM receptors control osteoblastic bone formation and identified MERTK as a novel target for bone anabolic therapy and mitigat
Externí odkaz:
https://doaj.org/article/ee00da2c9ae74841a30cb1a635750ba7
Autor:
Jonas S. Waizenegger, Victoria Gensch, Nikolaus Berenbrok, Maria Elena Vargas, Boris Fehse, Esteban Masuda, Isabel Ben Batalla, Sarina Paesler, Somasekhar Bhamidipati, Janik Engelmann, Ihab S. Darwish, Hanna Taipaleenmäki, Kristoffer Riecken, Klaus Pantel, Eric Hesse, Carsten Bokemeyer, Sonja Loges
Publikováno v:
Blood. 132:1922-1922
Despite many therapeutic advances in recent years Multiple Myeloma (MM) still remains incurable in the majority of the patients. In addition, MM patients suffer significantly from co-morbidities including bone pain and renal insufficiency. Therefore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdca8b08fd12ddd38fa8396afa35ec86
https://doi.org/10.1182/blood-2018-99-118273
https://doi.org/10.1182/blood-2018-99-118273
Autor:
H. Henry Lu, Rao Kolluri, Dane Goff, Peiyong Huang, Hui Hong, Ann Yen, Ning Sheng, Donald G. Payan, Emily Stauffer, Scott Crowder, Xiang Xu, Rajinder Singh, Anthony Martinez, Emily Anderson, Qi Huang, Eileen Goldstein, Todd Kinsella, Kunbin Qu, Philip Achacoso, Ihab S. Darwish, Sarkiz D. Issakani
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:1419-1429
Hepatitis C virus (HCV) infection is one of the major causes of viral hepatitis, with a great propensity to induce chronicity (21). Liver inflammation can persist for decades in chronic HCV infection and eventually leads to cirrhosis, end-stage liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc816a1f0197158d95e12488cd1f879
https://doi.org/10.1128/aac.00525-07
https://doi.org/10.1128/aac.00525-07
Autor:
J. Jeffry Howbert, Ted A. Baughman, John Latham, Devinder Singh, Thomas C. Cox, Kristin A. Kucera, Ihab S. Darwish, Richard Gelinas, Fred Ramsdell, Randy W. Jackson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1093-1097
A novel series of TNF-alpha inhibitors based on a benzobicyclooctane scaffold is reported. The compounds display good potency in inhibiting TNF-alpha induced apoptosis and NF kappa B activation. Additionally, they are selective for TNF-alpha as they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c8f05095728843f3eee511db4df064
https://doi.org/10.1016/s0960-894x(02)00098-7
https://doi.org/10.1016/s0960-894x(02)00098-7
Autor:
Gary Park, Esteban Masuda, Chi Young, Donald G. Payan, Sothy Yi, Jiaxin Yu, Matt Duan, Somasekhar Bhamidipati, Ernest Tai, Alexander Owyang, Ihab S. Darwish, David C.W. Lau, Stacey Siu, Meagan Chan, Rao Kolluri, Sacha Holland, Sylvia Braselmann, Roy Frances, Chrystelle Lamagna, Arthur Bagos
Publikováno v:
Cancer Immunology Research. 4:B060-B060
Introduction: In normal tissue homeostasis, interaction of phosphatidylserine externalized on apoptotic cells (ACs) with the TAM (Tyro3, Axl MerTK) family RTK MerTK, via its ligands Gas6 and Protein S, leads to AC phagocytosis (efferocytosis). The re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3652998c80d7f148c2dcb3527b383f1d
https://doi.org/10.1158/2326-6066.imm2016-b060
https://doi.org/10.1158/2326-6066.imm2016-b060
Autor:
Stacey Siu, Arthur Bagos, Rajinder Singh, Donald G. Payan, Sacha Holland, Roy Frances, Ernest Tai, Gary Park, Sothy Yi, Chi Young, Matt Duan, Esteban Masuda, Rao Kolluri, Somasekhar Bhamidipati, Ihab S. Darwish, Alexander Owyang, David Lau, Sylvia Braselmann, Matthew Duncton
Publikováno v:
Cancer Research. 76:4869-4869
Introduction: MerTK, a TAM (Tyro3, Axl, MerTK) family RTK, is expressed on phagocytic myeloid and epithelial cells. Its normal function is to dampen innate immune responses to self-antigens. MerTK is an indirect phosphatidylserine (PtdSer) receptor:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::404f22ec2758e63c6975b79e6e9aa223
https://doi.org/10.1158/1538-7445.am2016-4869
https://doi.org/10.1158/1538-7445.am2016-4869
Autor:
Ihab S. Darwish, Marvin J. Miller
Publikováno v:
The Journal of Organic Chemistry. 59:451-454
The first total and unequivocal syntheses of neoenactin A (1, NE A) as well as its N-deshydroxy analog 2 are described. The two key steps in the syntheses were the oxidative cleavage of an appropriate olefin 1-hexylcyclooctene (8a) to yield the desir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17458f17c87d61bd260ec9e2f9426c23
https://doi.org/10.1021/jo00081a027
https://doi.org/10.1021/jo00081a027
Publikováno v:
The Journal of Organic Chemistry. 58:6072-6075
The first total and unequivocal syntheses of (R)- and (S)-norneoenactin A (1), an analog of the antifungal antibiotic neoenactin A, are described. The key step of each synthesis was the Michael addition of a serinehydroxamate (5 or 8) to the appropri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fd1f7fc25a9956f1fd965d909f66765
https://doi.org/10.1021/jo00074a038
https://doi.org/10.1021/jo00074a038
Autor:
Marvin J. Miller, Ihab S. Darwish
Publikováno v:
ChemInform. 25
The first total and unequivocal syntheses of neoenactin A (1, NE A) as well as its N-deshydroxy analog 2 are described. The two key steps in the syntheses were the oxidative cleavage of an appropriate olefin 1-hexylcyclooctene (8a) to yield the desir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de2527507789d201f8c25c9152401b1e
https://doi.org/10.1002/chin.199423266
https://doi.org/10.1002/chin.199423266
Publikováno v:
ChemInform. 25
The first total and unequivocal syntheses of (R)- and (S)-norneoenactin A (1), an analog of the antifungal antibiotic neoenactin A, are described. The key step of each synthesis was the Michael addition of a serinehydroxamate (5 or 8) to the appropri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93eb65d34991b15b1dab71a919b808eb
https://doi.org/10.1002/chin.199408296
https://doi.org/10.1002/chin.199408296