Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Igor Zelko"'
Autor:
Mamata Chaudhari, Igor Zelko, Pawel Lorkiewicz, David Hoetker, Yibing Nong, Benjamin Doelling, Kenneth Brittian, Aruni Bhatnagar, Sanjay Srivastava, Shahid P. Baba
Publikováno v:
Skeletal Muscle, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Muscle wasting is a serious complication in heart failure patients. Oxidative stress and inflammation are implicated in the pathogenesis of muscle wasting. Oxidative stress leads to the formation of toxic lipid peroxidation products, such as
Externí odkaz:
https://doaj.org/article/e219c85edc9c4286b5285ba0bdfb315e
Publikováno v:
Molecular and Cellular Biology. 21:2838-2846
In response to phenobarbital (PB) and other PB-type inducers, the nuclear receptor CAR translocates to the mouse liver nucleus (T. Kawamoto et al., Mol. Cell. Biol. 19:6318-6322, 1999). To define the translocation mechanism, fluorescent protein-tagge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afbaf4f401577e14adbc79c98779f862
https://doi.org/10.1128/mcb.21.8.2838-2846.2001
https://doi.org/10.1128/mcb.21.8.2838-2846.2001
Autor:
Masahiko Negishi, Igor Zelko
Publikováno v:
Biochemical and Biophysical Research Communications. 277:1-6
Phenobarbital (PB) increases metabolic capability of hepatocytes by its ability to activate numerous genes encoding various xenochemical-metabolizing enzymes such as cytochrome P450s and specific transferases. More than 35 years since PB induction wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264ba6dc19e5332a2ed3b7ccc9c8a5dd
https://doi.org/10.1006/bbrc.2000.3557
https://doi.org/10.1006/bbrc.2000.3557
Publikováno v:
Molecular and Cellular Biology. 18:5652-5658
PBREM, the phenobarbital-responsive enhancer module of the cytochrome P-450 Cyp2b10 gene, contains two potential nuclear receptor binding sites, NR1 and NR2. Consistent with the finding that anti-retinoid X receptor (RXR) could supershift the NR1-nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252bf83e00a4608a8d7b0fd7313cb9ec
https://doi.org/10.1128/mcb.18.10.5652
https://doi.org/10.1128/mcb.18.10.5652
Autor:
Kimberly A. Washburn, Igor Zelko, Masahiko Negishi, Tatsuya Sueyoshi, Takeshi Kawamoto, Rick Moore
Publikováno v:
ResearcherID
The constitutively active receptor (CAR) transactivates a distal enhancer called the phenobarbital (PB)-responsive enhancer module (PBREM) found in PB-inducible CYP2B genes. CAR dramatically increases its binding to PBREM in livers of PB-treated mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627f95f1fddd9c694f56e35ce6b57297
https://europepmc.org/articles/PMC84602/
https://europepmc.org/articles/PMC84602/
Publikováno v:
The Journal of biological chemistry. 274(10)
The endogenous CYP2B6 gene becomes phenobarbital (PB) inducible in androstenol-treated HepG2 cells either transiently or stably transfected with a nuclear receptor CAR expression vector. The PB induction mediated by CAR is regulated by a conserved 51
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58168eb9b4ec3d021b08e5b8339b35af
https://pubmed.ncbi.nlm.nih.gov/10037683
https://pubmed.ncbi.nlm.nih.gov/10037683
Publikováno v:
Archives of biochemistry and biophysics. 352(1)
We cloned cDNAs which encode a mouse liver nuclear protein with an apparent molecular mass of 51 kDa, using sequences derived from a purified protein as the basis for designing specific primers. The deduced amino acid sequences revealed that the 51-k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3531fbeebef56f09873f2e9d1d20e16d
https://pubmed.ncbi.nlm.nih.gov/9521809
https://pubmed.ncbi.nlm.nih.gov/9521809