Modulation of Temoporfin Distribution in Blood by β-Cyclodextrin Nanoshuttles

Autor: Ilya Yakavets, Igor Yankovsky, Tatyana Zorina, Mikhail Belevtsev, Lina Bezdetnaya, Vladimir Zorin

Publikováno v: Pharmaceutics, Vol 13, Iss 7, p 1054 (2021)

Photodynamic therapy represents a more targeted and less invasive alternative cancer treatment to traditional modalities. Temoporfin, as with many photosensitizers, is given by injection into a vein, and its subsequent fate is largely determined by t

Externí odkaz: https://doaj.org/article/7dba9d27739340b9837bc4df0ef795e1

Evaluation of temoporfin affinity to β-cyclodextrins assuming self-aggregation

Autor: Lina Bezdetnaya, Igor Yankovsky, Vladimir Zorin, Henri-Pierre Lassalle, Antonio Monari, Ilya Yakavets, Francesca Ingrosso

Publikováno v: Journal of Photochemistry and Photobiology A: Chemistry
Journal of Photochemistry and Photobiology A: Chemistry, Elsevier, 2018, 367, pp.13-21. ⟨10.1016/j.jphotochem.2018.07.046⟩

International audience; The interaction between the potent photosensitizer meta-tetrakis(3-hydroxyphenyl)chlorin (temoporfin, mTHPC) and a series of β-cyclodextrins (β-CDs) was investigated using spectroscopic analysis and molecular dynamics simula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5008c6ba3e8ecfbd736d62d55e5929
https://doi.org/10.1016/j.jphotochem.2018.07.046

Modulation of Temoporfin Distribution in Blood by β-Cyclodextrin Nanoshuttles

Autor: Igor Yankovsky, Vladimir Zorin, Lina Bezdetnaya, Ilya Yakavets, Tatyana E. Zorina, Mikhail Belevtsev

Publikováno v: Pharmaceutics
Pharmaceutics, MDPI, 2021, 13 (7), pp.1054. ⟨10.3390/pharmaceutics13071054⟩
Volume 13
Issue 7
Pharmaceutics, Vol 13, Iss 1054, p 1054 (2021)

International audience; Photodynamic therapy represents a more targeted and less invasive alternative cancer treatment to traditional modalities. Temoporfin, as with many photosensitizers, is given by injection into a vein, and its subsequent fate is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15dfe0705325fc92634127a9ee4a341
https://doi.org/10.3390/pharmaceutics13071054

Inclusion complexation with β-cyclodextrin derivatives alters photodynamic activity and biodistribution of meta-tetra(hydroxyphenyl)chlorin

Autor: Ilya Yakavets, Lina Bezdetnaya, Henri-Pierre Lassalle, Vladimir Zorin, Igor Yankovsky, Susanna Gräfe, Estelle Bastien, Ivan I. Khludeyev

Publikováno v: European Journal of Pharmaceutical Sciences
European Journal of Pharmaceutical Sciences, Elsevier, 2016, 91, pp.172-182. ⟨10.1016/j.ejps.2016.06.012⟩

International audience; Application ofmeta-tetra(hydroxyphenyl)chorin (mTHPC) one of themost effective photosensitizer (PS) in photodynamic therapy of solid tumors encounters several complications resulting from its insolubility in aqueous medium. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8edc6614764be9dceb2f4e2ccec579
https://doi.org/10.1016/j.ejps.2016.06.012

The alteration of temoporfin distribution in multicellular tumor spheroids by β-cyclodextrins

Autor: Igor Yankovsky, Ilya Yakavets, Marie Millard, Arno Wiehe, Lina Bezdetnaya, Laureline Lamy, Henri-Pierre Lassalle, Vladimir Zorin

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2017, 529 (1-2), pp.568-575. ⟨10.1016/j.ijpharm.2017.07.037⟩

International audience; To be effective anticancer drugs must penetrate tissue efficiently, reaching all target population of cancer cells in a concentration sufficient to exert a therapeutic effect. This study aimed to investigate the ability of met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad4a850235782d3552762c36fe1c4ab
https://pubmed.ncbi.nlm.nih.gov/28711638