Výsledky vyhledávání - "Igor Vukobradovic"

Akademický článek

Hippocampal gene expression analysis highlights Ly6a/Sca-1 as candidate gene for previously mapped novelty induced behaviors in mice.

Autor: Simone de Jong, Martien J H Kas, Jeffrey Kiernan, Annetrude G de Mooij-van Malsen, Hugo Oppelaar, Esther Janson, Igor Vukobradovic, Charles R Farber, William L Stanford, Roel A Ophoff

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e20716 (2011)

In this study, we show that the covariance between behavior and gene expression in the brain can help further unravel the determinants of neurobehavioral traits. Previously, a QTL for novelty induced motor activity levels was identified on murine chr

Externí odkaz: https://doaj.org/article/bef945617f9a4f0cb28eeeacb080d89c

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Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen

Autor: Sara Wells, Marc Parisien, Abigail J. D’Souza, Rasneer Sonia Bains, Hamed Haselimashhadi, Mary E. Dickinson, Matthew Mckay, Amelia M. Willett, Christopher S. Ward, Robert Braun, Jeremy Mason, Stephen A. Murray, Emma Peterson, Michayla A. Moore, Damian Smedley, Erin E. Young, Luis Santos, Elissa L. Chesler, Laura C. Anderson, Rachel Urban, Helen Parkinson, Lynette Bower, John R. Seavitt, Dawei Qu, Leslie O. Goodwin, Vivek Kumar, Jason D. Heaney, Subhiksha Srinivasan, Kevin C K Lloyd, Mark E. Harrison, Steve D.M. Brown, Colin McKerlie, Ann M. Flenniken, Jacqueline K. White, Lauryl M. J. Nutter, Ziyue Huang, Jason A. Bubier, Daniel J. Delbarre, Robert P. Bonin, Kyle M. Baumbauer, Alexandr Bezginov, Dave Clary, Igor Vukobradovic, Ann-Marie Mallon, Silvia Mandillo, Luda Diatchenko, Surabi Veeraragavan, Michelle Stewart, Rodney C. Samaco, Janine M Wotton

Publikováno v: Pain (Amst. Print) (2021). doi:10.1097/j.pain.0000000000002481
info:cnr-pdr/source/autori:Wotton, Janine M.a; Peterson, Emmaa; Flenniken, Ann M.b,c; Bains, Rasneer S.d; Veeraragavan, Surabie,f; Bower, Lynette R.g; Bubier, Jason A.a; Parisien, March; Bezginov, Alexandrb,i; Haselimashhadi, Hamedj; Mason, Jeremyj; Moore, Michayla A.a; Stewart, Michelle E.d; Clary, Dave A.g; Delbarre, Daniel J.k; Anderson, Laura C.a; D'Souza, Abigailb,c; Goodwin, Leslie O.a; Harrison, Mark E.d; Huang, Ziyueb,c; Mckay, Matthewa; Qu, Daweib,c; Santos, Luisk; Srinivasan, Subhikshae; Urban, Rachela; Vukobradovic, Igorb,c; Ward, Christopher S.l; Willett, Amelia M.a; Braun, Robert E.a; Brown, Steve D.M.k; Dickinson, Mary E.l; Heaney, Jason D.e; Kumar, Viveka; Lloyd, K.C. Kentg,m; Mallon, Ann-Mariek; McKerlie, Colinc,i; Murray, Stephen A.a; Nutter, Lauryl M.J.b,i; Parkinson, Helenj; Seavitt, John R.e; Wells, Sarad; Samaco, Rodney C.e,f; Chesler, Elissa J.a; Smedley, Damiann; Diatchenko, Ludah; Baumbauer, Kyle M.o; Young, Erin E.p; Bonin, Robert P.q; Mandillo, Silviar; White, Jacqueline K.a,* The International Mouse Phenotyping Consortium/titolo:Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen/doi:10.1097%2Fj.pain.0000000000002481/rivista:Pain (Amst. Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume

Identifying the genetic determinants of pain is a scientific imperative given the magnitude of the global health burden that pain causes. Here, we report a genetic screen for nociception, performed under the auspices of the International Mouse Phenot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ba3068c6fd21cd20d394b0472d1cb8
https://doi.org/10.1097/j.pain.0000000000002481

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Cage-lid hanging behavior as a translationally relevant measure of pain in mice

Publikováno v: Pain

Supplemental Digital Content is Available in the Text. Cage-lid hanging behavior is impaired by sustained pain in mice and can be used as an ethologically valid and translationally relevant pain outcome measure.
The development of new analgesic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f962ef38ca883f16a41397a4208643
http://europepmc.org/articles/PMC8054539

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Forward genetic screen of mouse reveals dominant missense mutation in the P/Q-type voltage-dependent calcium channel, CACNA1A

Autor: Igor Vukobradovic, G. Xie, J. G. Sled, J. Rossant, Lucy R. Osborne, Jeffrey T. Henderson, S. J. Clapcote, S. P. Cordes, T. Tallerico, John C. Roder, Y. Huang, B. J. Nieman

Publikováno v: Genes, Brain and Behavior. 6:717-727

Dominant mutations of the P/Q-type Ca(2+) channel (CACNA1A) underlie several human neurological disorders, including episodic ataxia type 2, familial hemiplegic migraine 1 (FHM1) and spinocerebellar ataxia 6, but have not been found previously in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f2930b4630af7bcae34a902190e598
https://doi.org/10.1111/j.1601-183x.2007.00302.x

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Two mouse mutations mapped to chromosome 11 with differing morphologies but similar progressive inflammatory alopecia

Autor: Janet Rossant, Lucy R. Osborne, S. Lee Adamson, Ann M. Flenniken, Qiang Xu, Craig Fleming, Geoffrey A. Wood, Rebecca M Porter, Lily Morikawa, Colin McKerlie, Igor Vukobradovic

Publikováno v: Experimental Dermatology. 14:373-379

Alopecia is a common dermatological condition in humans and other mammals. Here, we present two similar but histologically distinct mouse models of scarring alopecia. Both mutant lines were generated using random genome-wide N-ethyl-N-nitrosourea mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed36057cc8123c65e8c2002d2acff712
https://doi.org/10.1111/j.1600-0625.2005.00291.x

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Assessment of Social Interaction Behaviors

Autor: Igor Vukobradovic, Tatiana V. Lipina, John C. Roder, Oksana Kaidanovich-Beilin, James R. Woodgett

Publikováno v: Journal of Visualized Experiments : JoVE

Social interactions are a fundamental and adaptive component of the biology of numerous species. Social recognition is critical for the structure and stability of the networks and relationships that define societies. For animals, such as mice, recogn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5c667f5330a2ee5bb73ac1a8078924
https://doi.org/10.3791/2473

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Hippocampal gene expression analysis highlights ly6a/sca-1 as candidate gene for previously mapped novelty induced behaviors in mice

Autor: H. Oppelaar, Igor Vukobradovic, William L. Stanford, Jeffrey Kiernan, Charles R. Farber, Annetrude J G de Mooij-van Malsen, Esther Janson, Simone de Jong, Martien J H Kas, Roel A. Ophoff

Publikováno v: PLoS One, 6, 1-6
PloS one, vol 6, iss 6
PLoS ONE
PLoS One, 6, 6, pp. 1-6
PLoS ONE, Vol 6, Iss 6, p e20716 (2011)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ef0323d6f66357f77a90bc20491a6e
https://doi.org/10.1371/journal.pone.0020716

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Prevalence of sexual dimorphism in mammalian phenotypic traits

Publikováno v: Nature Communications
Nature Communications, 2017, 8, ⟨10.1038/ncomms15475⟩
Nature communications, vol 8, iss 1
Nat. Commun. 8:15475 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22ff32917f16b5f536bab3a8bab6e17
https://hal.science/hal-03679179/file/islandora_77521.pdf

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