Zobrazeno 1 - 10
of 296
pro vyhledávání: '"Igor V. Ukrainets"'
Autor:
Svitlana V. Shishkina, Lidiya A. Petrushova, Kateryna O. Burian, Andrii I. Fedosov, Igor V. Ukrainets
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 76, Iss 10, Pp 1657-1660 (2020)
The title compound, C10H8ClNO5S, which has potential analgesic activity, crystallizes in space group P21/n. The benzothiazine ring system adopts an intermediate form between sofa and twist-boat conformations. The coplanarity of the ester substituent
Externí odkaz:
https://doaj.org/article/45391d17d89e4e8b901bc9c428dfca7e
Autor:
Igor V. Ukrainets, Lidiya A. Petrushova, Svitlana V. Shishkina, Lina A. Grinevich, Galina Sim
Publikováno v:
Scientia Pharmaceutica, Vol 84, Iss 4, Pp 705-714 (2016)
In order to obtain and then test pharmocologically any possible conformers of the new feasible analgesic N-benzyl-4-hydroxy-1-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide, its 4-O-sodium salt was synthesized using two methods. X-ray diffrac
Externí odkaz:
https://doaj.org/article/897c84164b3a48feb96bef9ab2f43043
Autor:
Igor V. Ukrainets, Lidiya A. Petrushova, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Tatiana V. Alekseeva, Inna I. Torianyk, Alexandra A. Davidenko
Publikováno v:
Scientia Pharmaceutica, Vol 88, Iss 1, p 10 (2020)
In order to identify new regularities of the “structure−analgesic activity” relationship in the series of 2,1-benzothiazine derivatives, the synthesis of methyl 4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate and a group of its analog
Externí odkaz:
https://doaj.org/article/4696a8b945a2491385221d3aa25cabdd
Autor:
Igor V. Ukrainets, Anna A. Burian, Ganna M. Hamza, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Kateryna O. Burian, Galina Sim
Publikováno v:
Scientia Pharmaceutica, Vol 87, Iss 2, p 12 (2019)
According to our quantum and chemical calculations 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid imidazolide is theoretically almost as reactive as its 2-carbonyl analog, and it forms the corresponding N-pyridyl-4-methyl-2,2-dioxo-1H-2
Externí odkaz:
https://doaj.org/article/15d84e402f4a47c8b7cc93a5cb476bc4
Autor:
Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Irina A. Danylova, Galina Sim
Publikováno v:
Scientia Pharmaceutica, Vol 87, Iss 2, p 10 (2019)
In order to detect new structural and biological patterns in a series of hetaryl-3-carboxylic acid derivatives, the optically pure (S)- and (R)-enantiomers of N-(1-arylethyl)-4-methyl- 2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides, their true race
Externí odkaz:
https://doaj.org/article/f935efcd86504569bed4b915612c9a6a
Autor:
Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Lina A. Grinevich, Vasyl V. Grynenko, Galina Sim
Publikováno v:
Scientia Pharmaceutica, Vol 86, Iss 4, p 50 (2018)
The analysis of our previous studies on the search for synthetic analgesics among N-R-amides of bicyclic hetaryl-3-carboxylic acids has been performed; on its basis N-hetaryl(aryl)-alkyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides have
Externí odkaz:
https://doaj.org/article/7e25eb729712445a907600312c1a7b5e
Autor:
Igor V. Ukrainets, Mykola Y. Golik, Lyudmila V. Sidorenko, Valentina I. Korniyenko, Lina A. Grinevich, Galina Sim, Olga V. Kryvanych
Publikováno v:
Scientia Pharmaceutica, Vol 86, Iss 3, p 31 (2018)
In accordance with the principles of “me-too” technique, the preparative method for obtaining has been proposed, and the synthesis of a large series of new N-(arylalkyl)-6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-5-carboxa
Externí odkaz:
https://doaj.org/article/16d87faa18e940aaa6d30e050aa38dca
Autor:
Igor V. Ukrainets, Anna A. Burian, Vyacheslav N. Baumer, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Igor A. Tugaibei, Natali I. Voloshchuk, Pavlo S. Bondarenko
Publikováno v:
Scientia Pharmaceutica, Vol 86, Iss 2, p 21 (2018)
Continuing the search for new potential analgesics among the derivatives of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid, the possibility of obtaining its esters by the alkylation of the corresponding sodium salt with iodoethane in di
Externí odkaz:
https://doaj.org/article/ccbbe397aef64496be980b1b58286aa3
Autor:
Igor V. Ukrainets, Lyudmila V. Sidorenko, Mykola Y. Golik, Igor M. Chernenok, Lina A. Grinevich, Alexandra A. Davidenko
Publikováno v:
Scientia Pharmaceutica, Vol 86, Iss 2, p 12 (2018)
Continuing a targeted search for new leading structures with diuretic action among tricyclic derivatives of hydroxyquinolines, which are of interest as potential inhibitors of aldosterone synthase, the synthesis of a series of the corresponding pyrid
Externí odkaz:
https://doaj.org/article/47de1e988c544d979d47f23d1b54b757
Autor:
Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Svitlana V. Shishkina, Natali I. Voloshchuk, Oxana V. Malchenko
Publikováno v:
Scientia Pharmaceutica, Vol 86, Iss 1, p 9 (2018)
In order to determine the regularities of the structure–analgesic activity relationship, the peculiarities of obtaining, the spatial structure, and biological properties of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid and some of it
Externí odkaz:
https://doaj.org/article/39fdab6f4d7041c0900f2688dd3593db