Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Igor V. Serkov"'
Autor:
Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Sofya V. Lushchekina, Tatiana Y. Astakhova, Elena N. Timokhina, Igor V. Serkov, Alexey N. Proshin, Yuliya V. Soldatova, Darya A. Poletaeva, Irina I. Faingold, Viktoriya A. Mumyatova, Alexey A. Terentiev, Eugene V. Radchenko, Vladimir A. Palyulin, Sergey O. Bachurin, Rudy J. Richardson
Publikováno v:
Molecules, Vol 29, Iss 2, p 321 (2024)
Effective therapeutics for Alzheimer’s disease (AD) are in great demand worldwide. In our previous work, we responded to this need by synthesizing novel drug candidates consisting of 4-amino-2,3-polymethylenequinolines conjugated with butylated hyd
Externí odkaz:
https://doaj.org/article/9dc8029bd61a4fcb9dc34956137feaf5
Autor:
Galina F. Makhaeva, Nadezhda V. Kovaleva, Natalia P. Boltneva, Elena V. Rudakova, Sofya V. Lushchekina, Tatiana Yu. Astakhova, Igor V. Serkov, Alexey N. Proshin, Eugene V. Radchenko, Vladimir A. Palyulin, Jan Korabecny, Ondrej Soukup, Sergey O. Bachurin, Rudy J. Richardson
Publikováno v:
Molecules, Vol 27, Iss 3, p 1060 (2022)
Using two ways of functionalizing amiridine—acylation with chloroacetic acid chloride and reaction with thiophosgene—we have synthesized new homobivalent bis-amiridines joined by two different spacers—bis-N-acyl-alkylene (3) and bis-N-thiourea-
Externí odkaz:
https://doaj.org/article/90ae90fd4e9f4057a738309e4978db2b
Autor:
Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Sofya V. Lushchekina, Irina I. Faingold, Darya A. Poletaeva, Yuliya V. Soldatova, Raisa A. Kotelnikova, Igor V. Serkov, Anatoly K. Ustinov, Alexey N. Proshin, Eugene V. Radchenko, Vladimir A. Palyulin, Rudy J. Richardson
Publikováno v:
Molecules, Vol 25, Iss 24, p 5891 (2020)
New hybrids of 4-amino-2,3-polymethylenequinoline with different sizes of the aliphatic ring linked to butylated hydroxytoluene (BHT) by enaminoalkyl (7) or aminoalkyl (8) spacers were synthesized as potential multifunctional agents for Alzheimer’s
Externí odkaz:
https://doaj.org/article/6ea0a7ce84b54558a5b89fe5c4b00ea2
Autor:
Ksenia M. Shestakova, Natalia E. Moskaleva, Natalia V. Mesonzhnik, Alexey V. Kukharenko, Igor V. Serkov, Igor I. Lyubimov, Elena V. Fomina-Ageeva, Vladimir V. Bezuglov, Mikhail G. Akimov, Svetlana A. Appolonova
Publikováno v:
Molecules, Vol 25, Iss 24, p 5896 (2020)
Prostanit is a novel drug developed for the treatment of peripheral arterial diseases. It consists of a prostaglandin E1 (PGE1) moiety with two nitric oxide (NO) donor fragments, which provide a combined vasodilation effect on smooth muscles and vasc
Externí odkaz:
https://doaj.org/article/69472e20970247caa7915ac4d6983d84
Autor:
Galina F. Makhaeva, Nadezhda V. Kovaleva, Natalia P. Boltneva, Sofya V. Lushchekina, Tatiana Yu. Astakhova, Elena V. Rudakova, Alexey N. Proshin, Igor V. Serkov, Eugene V. Radchenko, Vladimir A. Palyulin, Sergey O. Bachurin, Rudy J. Richardson
Publikováno v:
Molecules, Vol 25, Iss 17, p 3915 (2020)
New hybrid compounds of 4-amino-2,3-polymethylene-quinoline containing different sizes of the aliphatic ring and linked to p-tolylsulfonamide with alkylene spacers of increasing length were synthesized as potential drugs for treatment of Alzheimer’
Externí odkaz:
https://doaj.org/article/9f4ef364895f4df49c7e0f94abd6e832
Autor:
Mikhail G. Akimov, Denis S. Kudryavtsev, Elena V. Kryukova, Elena V. Fomina-Ageeva, Stanislav S. Zakharov, Natalia M. Gretskaya, Galina N. Zinchenko, Igor V. Serkov, Galina F. Makhaeva, Natalia P. Boltneva, Nadezhda V. Kovaleva, Olga G. Serebryakova, Sofya V. Lushchekina, Victor A. Palikov, Yulia Palikova, Igor A. Dyachenko, Igor E. Kasheverov, Victor I. Tsetlin, Vladimir V. Bezuglov
Publikováno v:
Biomolecules, Vol 10, Iss 2, p 283 (2020)
Cholines acylated with unsaturated fatty acids are a recently discovered family of endogenous lipids. However, the data on the biological activity of acylcholines remain very limited. We hypothesized that acylcholines containing residues of arachidon
Externí odkaz:
https://doaj.org/article/551c8934f5a34cb3af5aa30c2af613c4
Autor:
Alexey N. Proshin, Nadezhda V. Kovaleva, Galina F. Makhaeva, Igor V. Serkov, Sergey O. Bachurin, Ekaterina A. Kochetkova, N. P. Boltneva, Elena V. Rudakova
Publikováno v:
Mendeleev Communications. 31:606-608
A series of novel conjugates of 4-amino-2,3-polymethylene quinolines and phenolic antioxidant vanillin was synthesized by the condensation of aminoquinolines with vanillin followed by reduction of imines with sodium borohydride. The conjugates effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd6a880fa2b83a516692f463655886a0
https://doi.org/10.1016/j.mencom.2021.09.005
https://doi.org/10.1016/j.mencom.2021.09.005
Autor:
Galina F, Makhaeva, Nadezhda V, Kovaleva, Natalia P, Boltneva, Elena V, Rudakova, Sofya V, Lushchekina, Tatiana Yu, Astakhova, Igor V, Serkov, Alexey N, Proshin, Eugene V, Radchenko, Vladimir A, Palyulin, Jan, Korabecny, Ondrej, Soukup, Sergey O, Bachurin, Rudy J, Richardson
Publikováno v:
Molecules (Basel, Switzerland). 27(3)
Using two ways of functionalizing amiridine-acylation with chloroacetic acid chloride and reaction with thiophosgene-we have synthesized new homobivalent bis-amiridines joined by two different spacers-bis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c20c9c916bacf37be0cc40412520d8ba
https://pubmed.ncbi.nlm.nih.gov/35164325
https://pubmed.ncbi.nlm.nih.gov/35164325
Autor:
Igor V. Serkov, Nadezhda V. Kovaleva, Eugene V. Radchenko, Darya A Poletaeva, Galina F. Makhaeva, Rudy J. Richardson, I. I. Faingold, Elena V. Rudakova, R. A. Kotel’nikova, Sofya V. Lushchekina, A. K. Ustinov, N. P. Boltneva, Alexey N. Proshin, Yuliya V. Soldatova, Vladimir A. Palyulin
Publikováno v:
Molecules, Vol 25, Iss 5891, p 5891 (2020)
Molecules
Volume 25
Issue 24
Molecules
Volume 25
Issue 24
New hybrids of 4-amino-2,3-polymethylenequinoline with different sizes of the aliphatic ring linked to butylated hydroxytoluene (BHT) by enaminoalkyl (7) or aminoalkyl (8) spacers were synthesized as potential multifunctional agents for Alzheimer&rsq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d7355e822d741559dfb6562eb738ea
https://www.mdpi.com/1420-3049/25/24/5891
https://www.mdpi.com/1420-3049/25/24/5891
Autor:
Igor V. Serkov, Igor I Lyubimov, Svetlana A. Appolonova, Natalia E. Moskaleva, Fomina-Ageeva Ev, Natalia V. Mesonzhnik, Alexey Kukharenko, Vladimir V. Bezuglov, M. G. Akimov, Ksenia Shestakova
Publikováno v:
Molecules, Vol 25, Iss 5896, p 5896 (2020)
Molecules
Volume 25
Issue 24
Molecules
Volume 25
Issue 24
Prostanit is a novel drug developed for the treatment of peripheral arterial diseases. It consists of a prostaglandin E1 (PGE1) moiety with two nitric oxide (NO) donor fragments, which provide a combined vasodilation effect on smooth muscles and vasc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b96b00f23caea462be464eb40f94ff3
https://www.mdpi.com/1420-3049/25/24/5896
https://www.mdpi.com/1420-3049/25/24/5896