Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Igor V. Korobko"'
Autor:
Igor V. Korobko, M. V. Shepelev
Publikováno v:
Molecular Genetics, Microbiology and Virology. 34:228-233
Recombinant adenoviruses are widely used for delivery and expression of transgenes for therapeutic purposes and in fundamental research. AdEasy™ adenoviral vector system allows for rapid and efficient generation of replication-deficient adenoviruse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a242fe816e0c2d5dcb3a43630dcbb0a5
https://doi.org/10.3103/s0891416819040098
https://doi.org/10.3103/s0891416819040098
Autor:
Igor V. Korobko, Oksana Maksimenko, M. V. Tikhonov, Pavel Georgiev, Alexey V. Deykin, V A Kalmykov
Publikováno v:
Transgenic Research. 28:401-410
Expression of the reporter gene in transgenic animals depends on the surrounding chromatin environment. Recent genome-wide studies have shown that, in mammals, the entire genome is transcribed. Transcription through a transgene often has a negative e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ee26f4d69b42eb95aa0bf07e308962
https://doi.org/10.1007/s11248-019-00122-9
https://doi.org/10.1007/s11248-019-00122-9
Publikováno v:
Молекулярная биология. 53:411-420
Antithrombin III (AT3) belongs to the superfamily of serine protease inhibitors (serpins) and is a major anticoagulant in physiological conditions. Based on SERPINC1 gene, a minigene coding for human AT3, which is valuable for medicine and biotechnol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcd840fbc61c40598d8e99516536e123
https://doi.org/10.1134/s0026898419030170
https://doi.org/10.1134/s0026898419030170
Autor:
Svetlana V Kalinichenko, Keiji Itoh, Elena V Korobko, Sergei Y Sokol, Vladimir L Buchman, Igor V Korobko
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39505 (2012)
MAK-V/Hunk is a scantily characterized AMPK-like protein kinase. Recent findings identified MAK-V as a pro-survival and anti-apoptotic protein and revealed its role in embryonic development as well as in tumorigenesis and metastasis. However molecula
Externí odkaz:
https://doaj.org/article/384c65e2d6b54befaad2724241647885
Autor:
D S Korshunova, Sergei A. Nedospasov, Dmitry V. Kuprash, E. A. Gorshkova, M. A. Nosenko, A. V. Deikin, Ruslan V. Zvartsev, M. S. Drutskaya, Oksana Maksimenko, Igor V. Korobko, Kirill V. Korneev
Publikováno v:
Doklady Biochemistry and Biophysics. 483:344-347
To model human interleukin-6 (hIL-6) associated diseases, unique mice with transgenic overexpression of human IL-6 and reporter fluorescent protein EGFP in cells of macrophage-monocyte lineage were generated using loxP-Cre system. High level of hIL-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7577dcb82d65b0f2e3b620429078b6c9
https://doi.org/10.1134/s1607672918060157
https://doi.org/10.1134/s1607672918060157
Publikováno v:
Acta Naturae. 10:40-47
The use of transgenic animals as bioreactors for the synthesis of the recombinant proteins secreted into milk is a current trend in the development of biotechnologies. Advances in genetic engineering, in particular the emergence of targeted genome ed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::699b24570e95d62c06c37516b4a03a6c
https://doi.org/10.32607/20758251-2018-10-3-40-47
https://doi.org/10.32607/20758251-2018-10-3-40-47
Publikováno v:
Молекулярная биология. :501-507
The presence of introns is often required for efficient transgene expression. The use of full-length genes for transgenesis is associated with technical difficulties due to the large size of the genetic construct. To solve this problem, we recently s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb4a7c9bd07b6254a6711116d1e68f0a
https://doi.org/10.7868/s0026898418030138
https://doi.org/10.7868/s0026898418030138
Publikováno v:
Doklady Biochemistry and Biophysics. 485:150-152
A hybrid 6XRE-hTERT promoter consisting of the hTERT tumor-specific promoter and six copies of the XRE element from the CYP1A1 human gene promoter was created. Using a human lung cancer cells as a model, we showed that XRE elements in the hybrid prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43392b82f6737dabd81e98b50eaac683
https://doi.org/10.1134/s1607672919020200
https://doi.org/10.1134/s1607672919020200
Publikováno v:
Acta Naturae. 9:66-73
describe a novel hybrid tumor-specific promoter, ARE-hTERT, composed of the human TERT gene promoter (hTERT) and the antioxidant response element (ARE) from the human GCLM gene promoter. The hybrid promoter retains the tumor specificity of the basal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fd07714b033a27ffa071db2c3a0a407
https://doi.org/10.32607/20758251-2017-9-4-66-73
https://doi.org/10.32607/20758251-2017-9-4-66-73
Publikováno v:
Молекулярная биология. :671-676
Introns can frequently enhance transgene expression, and sometimes they are absolutely substantial. Based on an analysis of murine genes, in which mRNA does not have alternative splicing, a universal design of the efficiently spliced artificial intro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5085379fbff4d28498b4987e7e925d3
https://doi.org/10.7868/s0026898417040176
https://doi.org/10.7868/s0026898417040176