DNA polymerase swapping in Caudoviricetes bacteriophages

Autor: Natalya Yutin, Igor Tolstoy, Pascal Mutz, Yuri I. Wolf, Mart Krupovic, Eugene V. Koonin

Publikováno v: Virology Journal, Vol 21, Iss 1, Pp 1-12 (2024)

Abstract Background Viruses with double-stranded (ds) DNA genomes in the realm Duplodnaviria share a conserved structural gene module but show a broad range of variation in their repertoires of DNA replication proteins. Some of the duplodnaviruses en

Externí odkaz: https://doaj.org/article/2d986e9dffac478086a7957109414274

Analysis of metagenome-assembled viral genomes from the human gut reveals diverse putative CrAss-like phages with unique genomic features

Autor: Natalya Yutin, Sean Benler, Sergei A. Shmakov, Yuri I. Wolf, Igor Tolstoy, Mike Rayko, Dmitry Antipov, Pavel A. Pevzner, Eugene V. Koonin

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

Here, the authors analyze 4907 Circular Metagenome Assembled Genomes from human microbiomes and identify and characterize nearly 600 diverse genomes of crAss-like phages, finding two putative families with unusual genomic features, including high den

Externí odkaz: https://doaj.org/article/4ca86dc23a1341df935e8c557a11ea34

Type IV pili is a critical virulence factor in clinical isolates of Paenibacillus thiaminolyticus

Autor: Christine Hehnly, Aiqin Shi, Paddy Ssentongo, Lijun Zhang, Albert Isaacs, Sarah U. Morton, Nicholas Streck, Petra Erdmann-Gilmore, Igor Tolstoy, R. Reid Townsend, David D. Limbrick, Joseph N. Paulson, Jessica E. Ericson, Michael Y. Galperin, Steven J. Schiff, James R. Broach

Hydrocephalus, the leading indication for childhood neurosurgery worldwide, is particularly prevalent in low-and-middle-income countries (LMICs). Hydrocephalus preceded by an infection, or postinfectious hydrocephalus (PIH), accounts for up to 60% of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::144ab9c593b84ad93c222fba96f32dfa
https://doi.org/10.1101/2022.01.24.477451

Analysis of Spounaviruses as a Case Study for the Overdue Reclassification of Tailed Phages

Autor: Jakub Barylski, Hanna M. Oksanen, Johannes Wittmann, Annika Gillis, Peter Simmonds, Evelien M. Adriaenssens, Bas E. Dutilh, Robert Edwards, Petar Knezevic, Jochen Klumpp, Andrew M. Kropinski, Matthew B. Sullivan, Jens H. Kuhn, J. Rodney Brister, Rob Lavigne, Margo B.P. Schuller, François Enault, Pakorn Aiewsakun, Igor Tolstoy, Ho Bin Jang, Mart Krupovic

Publikováno v: Systems and Synthetic Biology, 69(1). Springer Netherlands
Systematic Biology, Vol. 69, no. 1, p. 110-123 (2020)
Systematic Biology
Systematic Biology, 2020, 69 (1), pp.110-123. ⟨10.1093/sysbio/syz036⟩
Systematic Biology, 69, 1, pp. 110-123
SYSTEMATIC BIOLOGY
Systematic Biology, 69 (1)
Systematic Biology, Oxford University Press (OUP), 2020, 69 (1), pp.110-123. ⟨10.1093/sysbio/syz036⟩
Systematic Biology, 69, 110-123

Tailed bacteriophages are the most abundant and diverse viruses in the world, with genome sizes ranging from 10 kbp to over 500 kbp. Yet, due to historical reasons, all this diversity is confined to a single virus order—Caudovirales, composed of ju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6621f5971e2c8e68ba600d641fb7be06
https://doi.org/10.1093/sysbio/syz036

Unique genomic features of crAss-like phages, the dominant component of the human gut virome

Autor: Mikhail Rayko, Sean Benler, Sergey Shmakov, Dmitry Antipov, Igor Tolstoy, Eugene V. Koonin, Yuri I. Wolf, Pavel A. Pevzner, Natalya Yutin

CrAssphage is the most abundant virus identified in the human gut virome and the founding member of a large group of bacteriophages that infect bacteria of the phylum Bacteroidetes and have been discovered by metagenomics of both animal-associated an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa740420daefb0db00ed966b1ab4e3fc
https://doi.org/10.1101/2020.07.20.212944