Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Igor Stagljar"'
Autor:
Jessica Knox, Andrew R. Burns, Brittany Cooke, Savina R. Cammalleri, Megan Kitner, Justin Ching, Jack M. P. Castelli, Emily Puumala, Jamie Snider, Emily Koury, J. B. Collins, Salma Geissah, James J. Dowling, Erik C. Andersen, Igor Stagljar, Leah E. Cowen, Mark Lautens, Inga Zasada, Peter J. Roy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Left unchecked, plant-parasitic nematodes have the potential to devastate crops globally. Highly effective but non-selective nematicides are justifiably being phased-out, leaving farmers with limited options for managing nematode infestation
Externí odkaz:
https://doaj.org/article/609af50dc9664af39474ef0017566555
Autor:
Vaishnavi V. Phadnis, Jamie Snider, Venkateshwari Varadharajan, Iyappan Ramachandiran, Amy A. Deik, Zon Weng Lai, Tenzin Kunchok, Elinor Ng Eaton, Carolin Sebastiany, Anna Lyakisheva, Kyle D. Vaccaro, Juliet Allen, Zhong Yao, Victoria Wong, Betty Geng, Kipp Weiskopf, Clary B. Clish, J. Mark Brown, Igor Stagljar, Robert A. Weinberg, Whitney S. Henry
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113023- (2023)
Summary: Ferroptosis is a form of regulated cell death with roles in degenerative diseases and cancer. Excessive iron-catalyzed peroxidation of membrane phospholipids, especially those containing the polyunsaturated fatty acid arachidonic acid (AA),
Externí odkaz:
https://doaj.org/article/f1a03612f457448787c70b44eca61b6d
Autor:
Sean Harrington, Jessica J. Knox, Andrew R. Burns, Ken-Loon Choo, Aaron Au, Megan Kitner, Cecile Haeberli, Jacob Pyche, Cassandra D’Amata, Yong-Hyun Kim, Jonathan R. Volpatti, Maximillano Guiliani, Jamie Snider, Victoria Wong, Bruna M. Palmeira, Elizabeth M. Redman, Aditya S. Vaidya, John S. Gilleard, Igor Stagljar, Sean R. Cutler, Daniel Kulke, James J. Dowling, Christopher M. Yip, Jennifer Keiser, Inga Zasada, Mark Lautens, Peter J. Roy
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
A C. elegans-based screening approach identifies nementin as a nematode-selective nematicide that can be used synergistically with acetylcholinesterase inhibitors
Externí odkaz:
https://doaj.org/article/b2ae40e60cd44727b137593ac69b190f
Autor:
Sun Jin Kim, Zhong Yao, Morgan C. Marsh, Debra M. Eckert, Michael S. Kay, Anna Lyakisheva, Maria Pasic, Aiyush Bansal, Chaim Birnboim, Prabhat Jha, Yannick Galipeau, Marc-André Langlois, Julio C. Delgado, Marc G. Elgort, Robert A. Campbell, Elizabeth A. Middleton, Igor Stagljar, Shawn C. Owen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Neutralisation assays are key to understanding immune responses to SARS-CoV-2 infection or vaccination. Here, the authors report a surrogate virus neutralization assay called Neu-SATiN, which measures neutralization directly from sera, and allows eas
Externí odkaz:
https://doaj.org/article/cb13b4c7a86945c89b15956fb496cbcb
Autor:
Shivanthy Pathmanathan, Zhong Yao, Paula Coelho, Robert Valla, Luka Drecun, Caroline Benz, Jamie Snider, Punit Saraon, Ingrid Grozavu, Max Kotlyar, Igor Jurisica, Morag Park, Igor Stagljar
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105419- (2022)
Summary: Met is an oncogene aberrantly activated in multiple cancers. Therefore, to better understand Met biology and its role in disease we applied the Mammalian Membrane Two-Hybrid (MaMTH) to generate a targeted interactome map of its interactions
Externí odkaz:
https://doaj.org/article/0a92c71625da4b51b6403321021367f4
Autor:
Nelson Martínez-Matías, Nataliya Chorna, Sahily González-Crespo, Lilliam Villanueva, Ingrid Montes-Rodríguez, Loyda M. Melendez-Aponte, Abiel Roche-Lima, Kelvin Carrasquillo-Carrión, Ednalise Santiago-Cartagena, Brian C. Rymond, Mohan Babu, Igor Stagljar, José R. Rodríguez-Medina
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Functional analysis of the Mtl1 protein in Saccharomyces cerevisiae has revealed that this transmembrane sensor endows yeast cells with resistance to oxidative stress through a signaling mechanism called the cell wall integrity pathway (CWI)
Externí odkaz:
https://doaj.org/article/f825aad1e0eb4f1d95efe613c725f24e
A homogeneous split-luciferase assay for rapid and sensitive detection of anti-SARS CoV-2 antibodies
Autor:
Zhong Yao, Luka Drecun, Farzaneh Aboualizadeh, Sun Jin Kim, Zhijie Li, Heidi Wood, Emelissa J. Valcourt, Kathy Manguiat, Simon Plenderleith, Lily Yip, Xinliu Li, Zoe Zhong, Feng Yun Yue, Tatiana Closas, Jamie Snider, Jelena Tomic, Steven J. Drews, Michael A. Drebot, Allison McGeer, Mario Ostrowski, Samira Mubareka, James M. Rini, Shawn Owen, Igor Stagljar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Serological tests are important diagnostic and disease surveillance tools for addressing the COVID-19 pandemic. Here, the authors present a tri-part Nanoluciferase based assay to detect antibodies against SARS-CoV-2.
Externí odkaz:
https://doaj.org/article/449b1c0635934549a4cf789704798ab6
Autor:
Vladimir Vélez-Segarra, Sahily González-Crespo, Ednalise Santiago-Cartagena, Luis E. Vázquez-Quiñones, Nelson Martínez-Matías, Yamirelis Otero, Julián J. Zayas, Rafael Siaca, Jeanmadi del Rosario, Inoushka Mejías, José J. Aponte, Noelani C. Collazo, Francisco J. Lasso, Jamie Snider, Matthew Jessulat, Hiroyuki Aoki, Brian C. Rymond, Mohan Babu, Igor Stagljar, José R. Rodríguez-Medina
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 9, Pp 3121-3135 (2020)
Antifungal drug discovery and design is very challenging because of the considerable similarities in genetic features and metabolic pathways between fungi and humans. However, cell wall composition represents a notable point of divergence. Therefore,
Externí odkaz:
https://doaj.org/article/213888786ea440eeb78f0cdc64041d9e
Autor:
Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 2, Pp n/a-n/a (2022)
Abstract Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride and bicarbonate channel in secretory epithelia with a critical role in maintaining fluid homeostasis. Mutations in CFTR are associated with Cystic Fibrosis (CF), the mo
Externí odkaz:
https://doaj.org/article/2333634eb31448bfa35a483208141fd8
Autor:
Zhong Yao, Farzaneh Aboualizadeh, Jason Kroll, Indira Akula, Jamie Snider, Anna Lyakisheva, Priscilla Tang, Max Kotlyar, Igor Jurisica, Mike Boxem, Igor Stagljar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Protein-protein interactions are fundamental to the regulation of protein activity and cellular phyisology. Here the authors present Split Intein-Mediated Protein Ligation, which uses bait and prey proteins fused to intein fragments to generate singl
Externí odkaz:
https://doaj.org/article/d7c200701845452a9c8b0403041b6f6f