Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Igor S. Tolokh"'
Publikováno v:
Epigenetics & Chromatin, Vol 17, Iss 1, Pp 1-17 (2024)
Abstract Background Multiple studies have demonstrated a negative correlation between gene expression and positioning of genes at the nuclear envelope (NE) lined by nuclear lamina, but the exact relationship remains unclear, especially in light of th
Externí odkaz:
https://doaj.org/article/7ddca1a8f3c84f8697c4f2f28c642c44
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-25 (2023)
Abstract Background Interactions among topologically associating domains (TADs), and between the nuclear envelope (NE) and lamina-associated domains (LADs) are expected to shape various aspects of three-dimensional (3D) chromatin structure and dynami
Externí odkaz:
https://doaj.org/article/744be59724a84d5e96f0ee6ac6ddb87c
Publikováno v:
Biophysical Journal. 122:69a
Multiple studies have shown a correlation between gene expression and positioning of genes at nuclear envelope (NE) lined by nuclear lamina. Here, we ask whether there is a causal, systematic connection between the expression level of the groups of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d162685c4933f9f6d489fa9e0bd9f51f
https://doi.org/10.1101/2022.02.17.480932
https://doi.org/10.1101/2022.02.17.480932
BackgroundInteractions among topologically associating domains (TADs), and between the nuclear envelope (NE) and lamina-associated domains (LADs) are expected to shape various aspects of 3D chromatin structure and dynamics; however, relevant genome-w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df5d8bdde5938af8d9ab436b9a336f2
https://doi.org/10.1101/2022.01.28.478236
https://doi.org/10.1101/2022.01.28.478236
Autor:
Lois Pollack, Andrea M. Katz, Alexey V. Onufriev, Nathan A. Baker, Suzette A. Pabit, Igor S. Tolokh
Publikováno v:
Biophysical Journal. 112:22-30
Interactions between the polyamine spermine and nucleic acids drive important cellular processes. Spermine condenses DNA and some RNAs, such as poly(rA):poly(rU). A large fraction of the spermine present in cells is bound to RNA but apparently does n
Publikováno v:
Web of Science
Publikováno v:
The Journal of Physical Chemistry B. 119:6092-6100
Charge hydration asymmetry (CHA)-a characteristic dependence of hydration free energy on the sign of the solute charge-quantifies the asymmetric response of water to electric field at microscopic level. Accurate estimates of CHA are critical for unde
Publikováno v:
Physical Review Letters. 117
Increasing the concentration of counterions (salt) is known to reduce the bending persistence length of DNA. Here we use atomistic molecular dynamics simulations to predict that multivalent counterions have the opposite effect on double-stranded RNA,
Publikováno v:
The Journal of Chemical Physics. 148:195101
The ion atmosphere around highly charged nucleic acid molecules plays a significant role in their dynamics, structure, and interactions. Here we utilized the implicit solvent framework to develop a model for the explicit treatment of ions interacting