Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Igor Rafalovich"'
Autor:
Anthony J. Deo, Michael E. Cahill, Siyu Li, Isaac Goldszer, Ruth Henteleff, Jon-Eric VanLeeuwen, Igor Rafalovich, Ruoqi Gao, Erin K. Stachowski, Allan R. Sampson, David A. Lewis, Peter Penzes, Robert A. Sweet
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 2, Pp 796-803 (2012)
Reductions in dendritic arbor length and complexity are among the most consistently replicated changes in neuronal structure in post mortem studies of cerebral cortical samples from subjects with schizophrenia, however, the underlying molecular mecha
Externí odkaz:
https://doaj.org/article/ce9d151c5cd645ba8f4c514eada7ef36
Autor:
Shenyu Zhai, Igor Rafalovich, Alexandria E Melendez, Joshua L. Plotkin, Asami Tanimura, D. James Surmeier
Publikováno v:
Cell Reports, Vol 13, Iss 7, Pp 1336-1342 (2015)
SummaryExperience-driven plasticity of glutamatergic synapses on striatal spiny projection neurons (SPNs) is thought to be essential to goal-directed behavior and habit formation. One major form of striatal plasticity, long-term depression (LTD), has
Autor:
D. James Surmeier, Luke E. Sebel, C. Savio Chan, Joshua L. Plotkin, Weixing Shen, Igor Rafalovich, Michelle Day
Publikováno v:
Journal of Neurophysiology. 110:2325-2336
The induction of corticostriatal long-term depression (LTD) in striatal spiny projection neurons (SPNs) requires coactivation of group I metabotropic glutamate receptors (mGluRs) and L-type Ca2+ channels. This combination leads to the postsynaptic pr
Autor:
Allan R. Sampson, Igor Rafalovich, Anthony J. Deo, Ruoqi Gao, Siyu Li, Erin K. Stachowski, Michael E. Cahill, Robert A. Sweet, Isaac M. Goldszer, Jon Eric VanLeeuwen, David A. Lewis, Peter Penzes, Ruth Henteleff
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 2, Pp 796-803 (2012)
Reductions in dendritic arbor length and complexity are among the most consistently replicated changes in neuronal structure in post mortem studies of cerebral cortical samples from subjects with schizophrenia, however, the underlying molecular mecha
Autor:
Richard J. Miller, Jon Eric VanLeeuwen, Deepak Srivastava, Igor Rafalovich, Peter Penzes, Katherine J. Sellers, Theanne N. Griffith, Rafiq Huda, Kelly A. Jones
Publikováno v:
Van Leeuwen, J-E, Rafalovich, I, Sellers, K, Jones, K A, Griffith, T N, Huda, R, Miller, R J, Srivastava, D & Penzes, P 2014, ' Coordinated Nuclear and Synaptic Shuttling of Afadin Promotes Spine Plasticity and Histone Modifications ', Journal of Biological Chemistry, vol. 289, no. 15, pp. 10831-10842 . https://doi.org/10.1074/jbc.M113.536391
The ability of a neuron to transduce extracellular signals into long lasting changes in neuronal morphology is central to its normal function. Increasing evidence shows that coordinated regulation of synaptic and nuclear signaling in response to NMDA
Autor:
Deepak Srivastava, Kevin M. Woolfrey, Michael E. Cahill, Srishti Mukherji, Igor Rafalovich, Bryan A. Copits, Zhong Xie, Kelly A. Jones, Peter Penzes, Jon Eric VanLeeuwen, Geoffrey T. Swanson, Rafiq Huda
The dendritic field of a neuron, which is determined by both dendritic architecture and synaptic strength, defines the synaptic input of a cell. Once established, a neuron's dendritic field is thought to remain relatively stable throughout a cell's l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6046d46826420bed4a89024eadadfe
https://europepmc.org/articles/PMC3476264/
https://europepmc.org/articles/PMC3476264/
Autor:
Peter Penzes, Igor Rafalovich
Publikováno v:
Synaptic Plasticity ISBN: 9783709109311
Spine morphogenesis is largely dependent on the remodeling of the actin cytoskeleton. Actin dynamics within spines is regulated by a complex network of signaling molecules, which relay signals from synaptic receptors, through small GTPases and their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cbb7620c8a8e1418d3b8ef985df70d
https://doi.org/10.1007/978-3-7091-0932-8_4
https://doi.org/10.1007/978-3-7091-0932-8_4
Autor:
Claudia S. Barros, Kelly A. Jones, Michael E. Cahill, Igor Rafalovich, Ulrich Müller, Zhong Xie, Peter Penzes
Publikováno v:
Molecular psychiatry
Neuregulin 1 (NRG1) is a secreted trophic factor that activates the postsynaptic erbB4 receptor tyrosine kinase. Both NRG1 and erbB4 have been repeatedly associated with schizophrenia, but their downstream targets are not well characterized. ErbB4 is
Autor:
Amanda R. Rowe, Cheryl L. Kirstein, Ashley E. Sponaugle, Shijie Song, Igor Rafalovich, Kimberly A. Badanich, Briony J. Catlow, Vasyl Sava, Juan Sanchez-Ramos
Publikováno v:
European journal of pharmacology. 628(1-3)
The use of 3,4,methylenedioxymethamphetamine (MDMA), the active agent in ecstasy, during adolescence is widespread yet the effects on adolescent behavior and brain development are unknown. The aim of the present study was 1) to evaluate effects of MD
Autor:
D. James Surmeier, C. Savio Chan, Jayms D. Peterson, Michael G. Kaplitt, Geraldine J. Kress, Zhong Xie, Mihaela Stavarache, Marc Flajolet, Jim Rosinski, Joshua L. Plotkin, Tracy S. Gertler, Michelle Day, Jyothisri Kondapalli, Igor Rafalovich, Paul Greengard
Publikováno v:
Neuron. (1):178-188
SUMMARY Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder. The debilitating choreic movements that plague HD patients have been attributed to striatal degeneration induced by the loss of cortically supplied brain-derived