Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: Its role in dendritic pathology

Autor: Anthony J. Deo, Michael E. Cahill, Siyu Li, Isaac Goldszer, Ruth Henteleff, Jon-Eric VanLeeuwen, Igor Rafalovich, Ruoqi Gao, Erin K. Stachowski, Allan R. Sampson, David A. Lewis, Peter Penzes, Robert A. Sweet

Publikováno v: Neurobiology of Disease, Vol 45, Iss 2, Pp 796-803 (2012)

Reductions in dendritic arbor length and complexity are among the most consistently replicated changes in neuronal structure in post mortem studies of cerebral cortical samples from subjects with schizophrenia, however, the underlying molecular mecha

Externí odkaz: https://doaj.org/article/ce9d151c5cd645ba8f4c514eada7ef36

Regulation of dendritic calcium release in striatal spiny projection neurons

Autor: D. James Surmeier, Luke E. Sebel, C. Savio Chan, Joshua L. Plotkin, Weixing Shen, Igor Rafalovich, Michelle Day

Publikováno v: Journal of Neurophysiology. 110:2325-2336

The induction of corticostriatal long-term depression (LTD) in striatal spiny projection neurons (SPNs) requires coactivation of group I metabotropic glutamate receptors (mGluRs) and L-type Ca2+ channels. This combination leads to the postsynaptic pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39ab45fe914d16c192da177ea67e051
https://doi.org/10.1152/jn.00422.2013

Coordinated nuclear and synaptic shuttling of afadin promotes spine plasticity and histone modifications

Autor: Richard J. Miller, Jon Eric VanLeeuwen, Deepak Srivastava, Igor Rafalovich, Peter Penzes, Katherine J. Sellers, Theanne N. Griffith, Rafiq Huda, Kelly A. Jones

Publikováno v: Van Leeuwen, J-E, Rafalovich, I, Sellers, K, Jones, K A, Griffith, T N, Huda, R, Miller, R J, Srivastava, D & Penzes, P 2014, ' Coordinated Nuclear and Synaptic Shuttling of Afadin Promotes Spine Plasticity and Histone Modifications ', Journal of Biological Chemistry, vol. 289, no. 15, pp. 10831-10842 . https://doi.org/10.1074/jbc.M113.536391

The ability of a neuron to transduce extracellular signals into long lasting changes in neuronal morphology is central to its normal function. Increasing evidence shows that coordinated regulation of synaptic and nuclear signaling in response to NMDA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8995a41fcfe4b65e6c8087ed1064b678
https://pubmed.ncbi.nlm.nih.gov/24567331

Regulation of the Actin Cytoskeleton in Dendritic Spines

Autor: Peter Penzes, Igor Rafalovich

Publikováno v: Synaptic Plasticity ISBN: 9783709109311

Spine morphogenesis is largely dependent on the remodeling of the actin cytoskeleton. Actin dynamics within spines is regulated by a complex network of signaling molecules, which relay signals from synaptic receptors, through small GTPases and their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cbb7620c8a8e1418d3b8ef985df70d
https://doi.org/10.1007/978-3-7091-0932-8_4

Effects of MDMA ('ecstasy') during adolescence on place conditioning and hippocampal neurogenesis

Autor: Amanda R. Rowe, Cheryl L. Kirstein, Ashley E. Sponaugle, Shijie Song, Igor Rafalovich, Kimberly A. Badanich, Briony J. Catlow, Vasyl Sava, Juan Sanchez-Ramos

Publikováno v: European journal of pharmacology. 628(1-3)

The use of 3,4,methylenedioxymethamphetamine (MDMA), the active agent in ecstasy, during adolescence is widespread yet the effects on adolescent behavior and brain development are unknown. The aim of the present study was 1) to evaluate effects of MD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d9f87e3184c0fed4cc794016865ef8
https://pubmed.ncbi.nlm.nih.gov/19932093