Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Igor R Wendt"'
Autor:
Kimberley M Mellor, James R Bell, Igor R Wendt, Amy J Davidoff, Rebecca H Ritchie, Lea M D Delbridge
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25204 (2011)
BACKGROUND: High dietary fructose has structural and metabolic cardiac impact, but the potential for fructose to exert direct myocardial action is uncertain. Cardiomyocyte functional responsiveness to fructose, and capacity to transport fructose has
Externí odkaz:
https://doaj.org/article/55211b0923dc4840ad11c3c18a8a2635
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 302:H964-H972
High fructose intake has been linked to insulin resistance and cardiac pathology. Dietary fructose-induced myocardial signaling and morphological alterations have been described, but whether cardiomyocyte function is influenced by chronic high fructo
Autor:
Igor R Wendt, Barbara K Kemp-Harper, Anke C. Rosenkranz, Rebecca H. Ritchie, John D. Horowitz, Ruchi Patel, Jennifer C Irvine
Publikováno v:
Pharmacology & Therapeutics. 124:279-300
Left ventricular hypertrophy (LVH), an increased left ventricular (LV) mass, is common to many cardiovascular disorders, initially developing as an adaptive response to maintain myocardial function. In the longer term, this LV remodelling becomes mal
Publikováno v:
European Journal of Pharmacology. 586:288-292
This study investigated sex-related differences in rat papillary muscle force generation in response to altered extracellular [Ca2+] ([Ca2+]o, 0.2 to 5.0 mM) and to L-type Ca2+ channel modulators (nifedipine and Bay K8644). At all [Ca2+]o examined, c
Autor:
Beata Zofia Zoltkowski, William Frederick Meeker, Igor R Wendt, Jocelyn Michelle Hammer, Richard J Lang
Publikováno v:
Journal of Urology. 177:1573-1580
We characterized membrane currents in smooth muscle cells and interstitial cells freshly isolated from the mouse ureteropelvic junction.Interstitial cells of Cajal-like cells were identified using c-Kit antibodies and fresh whole mount preparations o
Autor:
Beata Zofia Zoltkowski, William Frederick Meeker, Igor R Wendt, Mary A Tonta, Richard J Lang, Helena C. Parkington
Publikováno v:
The Journal of Physiology. 576:695-705
Pyeloureteric peristalsis has long been considered to be triggered by pacemaker atypical smooth muscle cells (SMC) located in the proximal regions of the renal pelvis. However, interstitial cells with many of the morphological features and c-Kit immu
Autor:
Igor R Wendt, Richard J. Paul
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 30:565-569
1. The aim of the present study was to investigate the effects of hypoxia on energy metabolism and contraction of rat urinary bladder smooth muscle, thereby gaining insight into the capacity of this smooth muscle to maintain contractile function when
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 30:489-494
1. The present study investigated the effects of ovariectomy (OVX) and 17β-oestradiol replacement on ‖Ca 2 + ‖ i in rat freshly isolated cardiac myocytes. 2. Myocytes were isolated from the hearts of sham, OVX and OVX + 17β-oestradiol-replaced
Autor:
Igor R Wendt, Thierry Pedrazzini, Leanne M. D. Delbridge, Chanchal Chandramouli, Claire L. Curl, Kimberley M. Mellor
Clinically, heart failure is an age-dependent pathological phenomenon and displays sex-specific characteristics. The renin-angiotensin system mediates cardiac pathology in heart failure. This study investigated the sexually dimorphic functional effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e240aa14311c0861d5e731bc6321cc
https://europepmc.org/articles/PMC4082583/
https://europepmc.org/articles/PMC4082583/
Publikováno v:
Pflügers Archiv. 441:709-716
The present study investigated the effects of gender on intracellular [Ca2+] ([Ca2+]i) in freshly isolated rat cardiac myocytes. Changes in [Ca2+]i in response to varied extracellular [Ca2+], different stimulus frequencies and addition of caffeine an