Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Igor Pottosin"'
Autor:
Igor Pottosin, Oxana Dobrovinskaya
Publikováno v:
Stress Biology, Vol 2, Iss 1, Pp 1-12 (2022)
Abstract Two-pore cation channel, TPC1, is ubiquitous in the vacuolar membrane of terrestrial plants and mediates the long distance signaling upon biotic and abiotic stresses. It possesses a wide pore, which transports small mono- and divalent cation
Externí odkaz:
https://doaj.org/article/a2b647f8f9684c12af4dc3d2269598d3
Publikováno v:
Cells, Vol 12, Iss 16, p 2065 (2023)
Degranulation mediated killing mechanism by NK cells is dependent on store-operated Ca2+ entry (SOCE) and has optimum at moderate intracellular Ca2+ elevations so that partial block of SOCE optimizes the killing process. In this study, we tested the
Externí odkaz:
https://doaj.org/article/0f6075c8d7b245f0a6960e22af3f35fe
Publikováno v:
Cellular Physiology and Biochemistry, Vol 54, Iss 5, Pp 842-852 (2020)
Externí odkaz:
https://doaj.org/article/eac031eb21f745ae8e35c5d272d00e18
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Glucocorticoids (GCs) are a central component of multi-drug treatment protocols against T and B acute lymphoblastic leukemia (ALL), which are used intensively during the remission induction to rapidly eliminate the leukemic blasts. The primary respon
Externí odkaz:
https://doaj.org/article/fdbc6b34075a43adbc21245b8937c3b8
Publikováno v:
Frontiers in Plant Science, Vol 11 (2021)
This work critically discusses the direct and indirect effects of natural polyamines and their catabolites such as reactive oxygen species and γ-aminobutyric acid on the activity of key plant ion-transporting proteins such as plasma membrane H+ and
Externí odkaz:
https://doaj.org/article/db065657a14c4a34af3b43d87b92f652
Autor:
Miguel Olivas-Aguirre, Liliana Torres-López, Kathya Villatoro-Gómez, Sonia Mayra Perez-Tapia, Igor Pottosin, Oxana Dobrovinskaya
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 366 (2022)
Cannabidiol (CBD), a major non-psychotropic component of cannabis, is receiving growing attention as a potential anticancer agent. CBD suppresses the development of cancer in both in vitro (cancer cell culture) and in vivo (xenografts in immunodefici
Externí odkaz:
https://doaj.org/article/6624975dd94b45e98e3211d949a6189d
Autor:
Miguel Olivas-Aguirre, Liliana Torres-López, Zeferino Gómez-Sandoval, Kathya Villatoro-Gómez, Igor Pottosin, Oxana Dobrovinskaya
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8688 (2021)
Cytotoxic effects of cannabidiol (CBD) and tamoxifen (TAM) have been observed in several cancer types. We have recently shown that CBD primarily targets mitochondria, inducing a stable mitochondrial permeability transition pore (mPTP) and, consequent
Externí odkaz:
https://doaj.org/article/8b90291957a049beb13df0fda3c2e3f3
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 204 (2020)
Anticancer activity of different phenols is documented, but underlying mechanisms remain elusive. Recently, we have shown that cannabidiol kills the cells of acute lymphoblastic leukemia (ALL) by a direct interaction with mitochondria, with their con
Externí odkaz:
https://doaj.org/article/790c4e8579e04ff5a9419db09748dee5
Autor:
Salvador Valle-Reyes, Georgina Valencia-Cruz, Liliana Liñan-Rico, Igor Pottosin, Oxana Dobrovinskaya
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Activation of resting T cells relies on sustained Ca2+ influx across the plasma membrane, which in turn depends on the functional expression of potassium channels, whose activity repolarizes the membrane potential. Depending on the T-cells subset, up
Externí odkaz:
https://doaj.org/article/89114dab254340c3b0eef8569c054af2
Autor:
Edgar Bonales-Alatorre, Igor Pottosin, Lana Shabala, Zhong-Hua Chen, Fanrong Zeng, Sven-Erik Jacobsen, Sergey Shabala
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 5, Pp 9267-9285 (2013)
Halophytes species can be used as a highly convenient model system to reveal key ionic and molecular mechanisms that confer salinity tolerance in plants. Earlier, we reported that quinoa (Chenopodium quinoa Willd.), a facultative C3 halophyte species
Externí odkaz:
https://doaj.org/article/34d25acc00324481abc7600a9bdbbfab