Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Igor Popa"'
Autor:
Veronika Sidova, Pavel Zoufaly, Jan Pokorny, Petr Dzubak, Marian Hajduch, Igor Popa, Milan Urban
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171621 (2017)
In this work, we describe synthesis of conjugates of betulinic acid with substituted triazoles prepared via Huisgen 1,3-cycloaddition. All compounds contain free 28-COOH group. Allylic bromination of protected betulinic acid by NBS gave corresponding
Externí odkaz:
https://doaj.org/article/bbf991cc9abd49d2a59f43911c64a602
Publikováno v:
Molecules, Vol 19, Iss 8, Pp 10832-10844 (2014)
The platinum(II) oxalato complexes [Pt(ox)(naza)2] (1–3) were synthesized and characterized by elemental analysis (C, H, N), multinuclear NMR spectroscopy (1H, 13C, 15N, 195Pt) and electrospray ionization mass spectrometry (ESI-MS); naza = 4-chloro
Externí odkaz:
https://doaj.org/article/06b066ead0994dc2b03e6aba3a4409dd
Publikováno v:
Molecules, Vol 19, Iss 3, Pp 3832-3847 (2014)
A one-step synthetic procedure using the reaction of potassium bis(oxalato)platinate(II) with the corresponding N6-benzyladenosine derivative (nL) provided the [Pt(ox)(nL)2]∙1.5H2O oxalato (ox) complexes 1–5, involving the nL molecules as monoden
Externí odkaz:
https://doaj.org/article/3bbdfe88e4c5484c8fc9cb465a0bf488
Publikováno v:
Molecules, Vol 18, Iss 6, Pp 6990-7003 (2013)
The platinum(II) complexes trans-[PtCl2(Ln)2]∙xSolv 1–13 (Solv = H2O or CH3OH), involving N6-benzyladenosine-based N-donor ligands, were synthesized; Ln stands for N6-(2-methoxybenzyl)adenosine (L1, involved in complex 1), N6-(4-methoxy-benzyl)ad
Externí odkaz:
https://doaj.org/article/2147ba188f7f4437be293f9b83dbcbc2
Publikováno v:
Molecules, Vol 23, Iss 1, p 149 (2018)
The cyclin-dependent kinase inhibitor, CAN508, was protected with di-tert-butyl dicarbonate to access the amino-benzoylated pyrazoles. The bromo derivatives were further arylated by Suzuki-Miyaura coupling using the XPhos Pd G2 pre-catalyst. The coup
Externí odkaz:
https://doaj.org/article/d864cfeb490e401796fa5db8fa1feecc
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144613 (2015)
Copper-free click reactions between a dibenzoazocine derivative and azides derived from 5-methyluridine were investigated. The non-catalyzed reaction yielded both regioisomers in an approximately equivalent ratio. The NMR spectra of each regioisomer
Externí odkaz:
https://doaj.org/article/a93f36e84daf427184ff936cff00fbc5
Autor:
Pavel Starha, Jan Hošek, Ján Vančo, Zdeněk Dvořák, Pavel Suchý, Igor Popa, Gabriela Pražanová, Zdeněk Trávníček
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90341 (2014)
The in vitro antitumour activity studies on a panel of human cancer cell lines (A549, HeLa, G-361, A2780, and A2780R) and the combined in vivo and ex vivo antitumour testing on the L1210 lymphocytic leukaemia model were performed on the cis-[PtCl2(na
Externí odkaz:
https://doaj.org/article/b34a90ccc34f4d71b2adf29021b4c2db
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 4, Pp o533-o533 (2013)
The molecule of the title compound, C19H23N5O3, contains six-membered pyrimidine and five-membered imidazole rings merged into the essentially planar purine skeleton (r.m.s. deviation = 0.01 Å). In the crystal, pairs of N—H...N hydrogen bonds link
Externí odkaz:
https://doaj.org/article/071429c3921843d0acc36f7bb3f5621a
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 4, Pp o588-o588 (2013)
The title compound, C17H19N5O2, features an almost planar purine skeleton (r.m.s. deviation = 0.009 Å) substituted by a tetrahydrofuran ring, which adopts an envelope conformation. The purine and benzene rings subtend a dihedral angle of 66.70 (3)°
Externí odkaz:
https://doaj.org/article/32b40489651b473294e2562405f27cd9
Autor:
Sona Gurska, Lucie Borkova, Petr Dzubak, Marian Hajduch, Renata Burianova, Milan Urban, Igor Popa, Jan Sarek
Publikováno v:
European Journal of Medicinal Chemistry. 121:120-131
Lupane derivatives containing an electronegative substituent in the position 2 of the skeleton are often cytotoxic, however, the most active compounds are not selective enough. To further study the influence of a substituent in the position 2 in lupa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c40894e94c2e2b3eaf194b2a16bafbf
https://doi.org/10.1016/j.ejmech.2016.05.029
https://doi.org/10.1016/j.ejmech.2016.05.029