Excitotoxic glutamate causes neuronal insulin resistance by inhibiting insulin receptor/Akt/mTOR pathway

Autor: Igor Pomytkin, Irina Krasil’nikova, Zanda Bakaeva, Alexander Surin, Vsevolod Pinelis

Publikováno v: Molecular Brain, Vol 12, Iss 1, Pp 1-4 (2019)

Abstract Aim An impaired biological response to insulin in the brain, known as central insulin resistance, was identified during stroke and traumatic brain injury, for which glutamate excitotoxicity is a common pathogenic factor. The exact molecular

Externí odkaz: https://doaj.org/article/caa7739e3eac4798948fd603d0c43234

Insulin Receptors and Intracellular Ca2+ Form a Double-Negative Regulatory Feedback Loop Controlling Insulin Sensitivity [version 2; peer review: 3 approved]

Autor: Igor Pomytkin, Vsevolod Pinelis

Publikováno v: F1000Research, Vol 9 (2021)

Since the discovery of insulin and insulin receptors (IR) in the brain in 1978, numerous studies have revealed a fundamental role of IR in the central nervous system and its implication in regulating synaptic plasticity, long-term potentiation and de

Externí odkaz: https://doaj.org/article/29e81a5cd6034a0c8244237540a6c338

Brain Insulin Resistance: Focus on Insulin Receptor-Mitochondria Interactions

Autor: Igor Pomytkin, Vsevolod Pinelis

Publikováno v: Life, Vol 11, Iss 3, p 262 (2021)

Current hypotheses implicate insulin resistance of the brain as a pathogenic factor in the development of Alzheimer’s disease and other dementias, Parkinson’s disease, type 2 diabetes, obesity, major depression, and traumatic brain injury. A vari

Externí odkaz: https://doaj.org/article/6d1d9c3653be4775b052e721fe66c5fa

Molecular and behavioural abnormalities in the FUS-tg mice mimic frontotemporal lobar degeneration

Autor: Diana Babaevskaya, Andrey Proshin, Igor Pomytkin, Margarita Oplatchikova, Tatyana Strekalova, Johannes P.J.M. de Munter, D. A. Pavlov, Allan V. Kalueff, Klaus-Peter Lesch, Ekaterina Lysikova, Anna Gorlova, Erik Ch. Wolters, Aleksei Umriukhin

Publikováno v: Journal of Cellular and Molecular Medicine, 24(17), 10251-10257. Wiley-Blackwell
Journal of Cellular and Molecular Medicine
J. Cell. Mol. Med.

Genetic mutations in FUS, a DNA/RNA-binding protein, are associated with inherited forms of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). A novel transgenic FUS[1-359]-tg mouse line recapitulates core hallmarks of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06827f1ecd2f754817e6fe6568533e8
https://cris.maastrichtuniversity.nl/en/publications/0162d1c6-abc0-4610-83d0-566d46a45289

Fluorescent Analysis Reveals that Insulin Diminishes Superoxide Increase in Neurons Induced with Toxic Glutamate Treatment

Autor: Olga A. Krasilnikova, Zanda Bakaeva, Dmitry Boyarkin, Vsevolod Pinelis, Alexander Surin, Andrey P. Fisenko, Igor Pomytkin, Irina Krasil’nikova

Glutamate excitotoxicity is implicated in the pathogenesis of many disorders, including stroke, traumatic brain injury, and Alzheimer’s disease, for which central insulin resistance is a comorbid condition. Massive glutamate release primarily throu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0005351fdba41885b02a87b7c5dcac5